Detailed view for Smp_169770

Basic information

TDR Targets ID: 295632
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.9917 | Length (AA): 620 | MW (Da): 70880 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04114   Gaa1-like, GPI transamidase component

Gene Ontology

Mouse over links to read term descriptions.
GO:0042765   GPI-anchor transamidase complex  
GO:0016021   integral to membrane  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
76 239 1tkj (A) 27 190 13.00 0.0028 0.37 0.303716 -0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130113)

Species Accession Gene Product
Arabidopsis thaliana AT5G19130   GPI transamidase component family protein / Gaa1-like family protein
Brugia malayi Bm1_05415   glycosylphosphatidylinositol anchor attachment 1 (GPAA1)-like
Candida albicans CaO19.5693   similar to S. cerevisiae GAA1 (YLR088W) subunit of GPI transamidase complex
Dictyostelium discoideum DDB_G0287287   hypothetical protein
Drosophila melanogaster Dmel_CG3033   Glycosylphosphatidylinositol anchor attachment 1 ortholog (H. sapiens)
Echinococcus granulosus EgrG_000167400   glycosylphosphatidylinositol anchor attachment 1
Echinococcus multilocularis EmuJ_000167400   glycosylphosphatidylinositol anchor attachment 1
Homo sapiens 101930385   glycosylphosphatidylinositol anchor attachment 1 protein-like
Homo sapiens 102725211   glycosylphosphatidylinositol anchor attachment 1 protein-like
Homo sapiens ENSG00000197858   glycosylphosphatidylinositol anchor attachment 1
Loa Loa (eye worm) LOAG_13876   hypothetical protein
Loa Loa (eye worm) LOAG_06172   hypothetical protein
Mus musculus ENSMUSG00000022561   GPI anchor attachment protein 1
Oryza sativa 4324399   Os01g0682200
Saccharomyces cerevisiae YLR088W   Gaa1p
Schistosoma japonicum Sjp_0069790   ko:K05289 glycosylphosphatidylinositol transamidase, putative
Schistosoma mansoni Smp_169770   hypothetical protein
Schmidtea mediterranea mk4.001060.03   Glycosylphosphatidylinositol anchor attachment 1 protein
Schmidtea mediterranea mk4.001060.01   Glycosylphosphatidylinositol anchor attachment 1 protein

Essentiality

Smp_169770 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YLR088W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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