Detailed view for Smp_082050

Basic information

TDR Targets ID: 295637
Schistosoma mansoni, ubiquitin-conjugating enzyme E2-25kD
Source Database / ID:  GeneDB

pI: 6.1361 | Length (AA): 225 | MW (Da): 24845 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00179   Ubiquitin-conjugating enzyme
PF00627   UBA/TS-N domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0019787   small conjugating protein ligase activity  
GO:0005515   protein binding  
GO:0051246   regulation of protein metabolic process  
GO:0043687   post-translational protein modification  

Metabolic Pathways

Ubiquitin mediated proteolysis (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 224 3k9o (A) 3 198 57.00 0 1 1.69431 -1.6
69 151 2gjd (A) 45 128 40.00 0 1 0.927089 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128826)

Species Accession Gene Product
Arabidopsis thaliana AT5G50870   ubiquitin-conjugating enzyme E2 27
Babesia bovis BBOV_IV010700   ubiquitin-conjugating enzyme, putative
Brugia malayi Bm1_46545   Ubiquitin-conjugating enzyme E2-25 kDa
Candida albicans CaO19.8686   likely ubiquitin-conjugating enzyme similar to S. cerevisiae UBC1 (YDR177W)
Candida albicans CaO19.1085   likely ubiquitin-conjugating enzyme similar to S. cerevisiae UBC1 (YDR177W)
Caenorhabditis elegans CELE_C06E2.3   Protein UBC-21
Caenorhabditis elegans CELE_F40G9.3   Protein UBC-20
Cryptosporidium hominis Chro.40035   ubiquitin-conjugating enzyme
Cryptosporidium parvum cgd4_210   Ubc1p like ubiquitin-conjugating enzyme E2 fused to a UBA domain (UBC+UBA)
Drosophila melanogaster Dmel_CG8284   Ubiquitin conjugating enzyme 4
Echinococcus granulosus EgrG_000775500   ubiquitin conjugating enzyme E2 25kD
Echinococcus multilocularis EmuJ_000775500   ubiquitin conjugating enzyme E2 25kD
Loa Loa (eye worm) LOAG_10437   hypothetical protein
Mus musculus ENSMUSG00000029203   ubiquitin-conjugating enzyme E2K
Neospora caninum NCLIV_049890   ubiquitin-conjugating enzyme, putative
Oryza sativa 4327237   Os01g0925800
Plasmodium berghei PBANKA_1132600   ubiquitin-conjugating enzyme E2, putative
Plasmodium falciparum PF3D7_1356300   ubiquitin-conjugating enzyme E2, putative
Plasmodium knowlesi PKNH_1115200   ubiquitin-conjugating enzyme E2, putative
Plasmodium vivax PVX_114795   ubiquitin-conjugating enzyme, putative
Plasmodium yoelii PY01609   ubiquitin conjugating enzyme
Saccharomyces cerevisiae YDR177W   E2 ubiquitin-conjugating protein UBC1
Schistosoma japonicum Sjp_0008090   ko:K04649 ubiquitin-conjugating enzyme (huntingtin interacting protein 2), putative
Schistosoma mansoni Smp_082050   ubiquitin-conjugating enzyme E2-25kD
Schmidtea mediterranea mk4.004633.00  
Schmidtea mediterranea mk4.015744.00  
Schmidtea mediterranea mk4.000385.02  
Schmidtea mediterranea mk4.017954.00   Ubiquitin-conjugating enzyme E2 K
Schmidtea mediterranea mk4.035167.00  
Schmidtea mediterranea mk4.023137.00  
Schmidtea mediterranea mk4.005617.00  
Schmidtea mediterranea mk4.011199.00  
Schmidtea mediterranea mk4.000724.05   Ubiquitin-conjugating enzyme E2 K
Schmidtea mediterranea mk4.000462.01  
Schmidtea mediterranea mk4.004937.00  
Schmidtea mediterranea mk4.003962.02  
Schmidtea mediterranea mk4.002271.02   Ubiquitin-conjugating enzyme E2 K
Schmidtea mediterranea mk4.005137.00  
Schmidtea mediterranea mk4.031522.00  
Schmidtea mediterranea mk4.015744.02  
Schmidtea mediterranea mk4.014222.03  
Schmidtea mediterranea mk4.004633.02  
Schmidtea mediterranea mk4.012440.00  
Schmidtea mediterranea mk4.011141.03  
Schmidtea mediterranea mk4.022378.00   Ubiquitin-conjugating enzyme E2 K
Schmidtea mediterranea mk4.016636.00  
Schmidtea mediterranea mk4.021601.00   Ubiquitin-conjugating enzyme E2 K
Schmidtea mediterranea mk4.000478.09   Ubiquitin-conjugating enzyme E2 K
Schmidtea mediterranea mk4.007893.01  
Schmidtea mediterranea mk4.010632.00  
Schmidtea mediterranea mk4.019342.00  
Toxoplasma gondii TGME49_235450   ubiquitin-conjugating enzyme subfamily protein
Theileria parva TP01_0732   ubiquitin conjugating enzyme, putative

Essentiality

Smp_082050 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YDR177W Saccharomyces cerevisiae inviable yeastgenome
TGME49_235450 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_082050 (Schistosoma mansoni), ubiquitin-conjugating enzyme E2-25kD
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