Detailed view for LmjF.25.2460

Basic information

TDR Targets ID: 29564
Leishmania major, phosphoglycan beta 1,3 galactosyltransferase 6
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.3586 | Length (AA): 814 | MW (Da): 91255 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01762   Galactosyltransferase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008378   galactosyltransferase activity  
GO:0006486   protein amino acid glycosylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
234 417 1te2 (A) 5 197 8.00 0 0 0.12 -0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129839)

Species Accession Gene Product
Leishmania braziliensis LbrM.21.0010   phosphoglycan beta 1,3 galactosyltransferase 2
Leishmania braziliensis LbrM.35.0010   phosphoglycan beta 1,3 galactosyltransferase 4
Leishmania braziliensis LbrM.07.1250   phosphoglycan beta 1,3 galactosyltransferase 1
Leishmania braziliensis LbrM.07.0240   phosphoglycan beta 1,3 galactosyltransferase 1
Leishmania braziliensis LbrM.35.0060   phosphoglycan beta 1,3 galactosyltransferase 4
Leishmania donovani LdBPK_141500.1   phosphoglycan beta 1,3 galactosyltransferase, putative
Leishmania infantum LinJ.35.0010   phosphoglycan beta 1,3 galactosyltransferase 7
Leishmania infantum LinJ.36.0010   phosphoglycan beta 1,3 galactosyltransferase 4
Leishmania infantum LinJ.31.3330   phosphoglycan beta 1,3 galactosyltransferase 5
Leishmania infantum LinJ.21.0010   phosphoglycan beta 1,3 galactosyltransferase 2
Leishmania infantum LinJ.14.1500   phosphoglycan beta 1,3 galactosyltransferase, putative
Leishmania infantum LinJ.25.2570   phosphoglycan beta 1,3 galactosyltransferase 6
Leishmania major LmjF.36.0010   phosphoglycan beta 1,3 galactosyltransferase 4
Leishmania major LmjF.21.0010   phosphoglycan beta 1,3 galactosyltransferase 2
Leishmania major LmjF.02.0010   phosphoglycan beta 1,3 galactosyltransferase 3
Leishmania major LmjF.35.0010   phosphoglycan beta 1,3 galactosyltransferase 7
Leishmania major LmjF.25.2460   phosphoglycan beta 1,3 galactosyltransferase 6
Leishmania major LmjF.14.1400   phosphoglycan beta 1,3 galactosyltransferase, putative
Leishmania major LmjF.31.3190   phosphoglycan beta 1,3 galactosyltransferase 5
Leishmania major LmjF.07.1170   phosphoglycan beta 1,3 galactosyltransferase 1
Leishmania mexicana LmxM.07.1170   phosphoglycan beta 1,3 galactosyltransferase 1
Leishmania mexicana LmxM.30.3190   phosphoglycan beta 1,3 galactosyltransferase 5
Leishmania mexicana LmxM.25.2460   phosphoglycan beta 1,3 galactosyltransferase 6
Leishmania mexicana LmxM.36.0010   phosphoglycan beta 1,3 galactosyltransferase 4
Trypanosoma brucei gambiense Tbg972.4.5430   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei gambiense Tbg972.8.7400   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei gambiense Tbg972.8.7390   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei gambiense Tbg972.4.5440   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb11.v5.0880   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.8.7140   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.4.5290   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.4.5250   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.4.5240   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.4.5280   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.4.5270   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.4.5260   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.4.5300   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma brucei Tb927.8.7150   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_8_7230   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_20690   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_37440   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_59240   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_59740   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_34690   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_26960   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_34720   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_58810   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_20680   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_59230   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_59260   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_18980   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_34700   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative
Trypanosoma congolense TcIL3000_0_59220   UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase, putative

Essentiality

LmjF.25.2460 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.5240 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.5240 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.5240 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.5240 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.7150 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7150 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.7150 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7150 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.7140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7140 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.7140 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7140 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LmjF.25.2460 (Leishmania major), phosphoglycan beta 1,3 galactosyltransferase 6
Title for this comment
Comment