Detailed view for Smp_160940

Basic information

TDR Targets ID: 295657
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.6404 | Length (AA): 720 | MW (Da): 78798 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat
PF04494   WD40 associated region in TFIID subunit, NTD2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0030528   transcription regulator activity  
GO:0005515   protein binding  
GO:0045449   regulation of transcription  

Metabolic Pathways

Basal transcription factors (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
30 717 6f3t (A) 208 797 30.00 0 1 0.833456 1.04
32 658 6f3t (A) 210 789 43.00 0 1 1.21163 -0.08
33 164 2j49 (A) 149 282 31.00 0 1 0.784133 -2.28
37 166 2j4b (A) 20 148 28.00 0 1 0.746456 -2.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128980)

Species Accession Gene Product
Arabidopsis thaliana AT5G25150   TBP-associated factor 5
Babesia bovis BBOV_III002720   WD domain, G-beta repeat containing protein
Brugia malayi Bm1_47705   WD40 associated region in TFIID subunit family protein
Candida albicans CaO19.8169   WD40 repeat protein similar to S. cerevisiae TAF5 (YBR198C) subunit of TFIID and SAGA complexes, involved in RNA polymerase II t
Candida albicans CaO19.536   WD40 repeat protein similar to S. cerevisiae TAF5 (YBR198C) subunit of TFIID and SAGA complexes, involved in RNA polymerase II t
Caenorhabditis elegans CELE_F30F8.8   Protein TAF-5
Cryptosporidium hominis Chro.10291   transcription initiation factor TFIID subunit
Cryptosporidium parvum cgd1_2600   transcription factor TAF5p, TBP associated protein involved in transcription
Dictyostelium discoideum DDB_G0287337   TFIID subunit
Drosophila melanogaster Dmel_CG7704   TBP-associated factor 5
Echinococcus granulosus EgrG_000245700   transcription initiation factor tfiid subunit 5
Entamoeba histolytica EHI_198960   transcription initiation factor TFIID subunit 5, putative
Echinococcus multilocularis EmuJ_000245700   transcription initiation factor tfiid subunit 5
Homo sapiens ENSG00000148835   TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Loa Loa (eye worm) LOAG_10999   WD40 associated region in TFIID subunit family protein
Mus musculus ENSMUSG00000025049   TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Oryza sativa 4341679   Os06g0649500
Saccharomyces cerevisiae YBR198C   Taf5p
Schistosoma japonicum Sjp_0065440   ko:K03130 transcription initiation factor TFIID subunit D4, putative
Schistosoma mansoni Smp_160940   hypothetical protein
Schmidtea mediterranea mk4.005974.02  
Schmidtea mediterranea mk4.000564.03  
Schmidtea mediterranea mk4.002912.02  
Schmidtea mediterranea mk4.016638.00  
Theileria parva TP04_0078   hypothetical protein
Theileria parva TP04_0077   hypothetical protein
Trichomonas vaginalis TVAG_265450   WD-repeat protein, putative
Trichomonas vaginalis TVAG_206920   WD-repeat protein, putative

Essentiality

Smp_160940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F30F8.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F30F8.8 Caenorhabditis elegans larval lethal wormbase
CELE_F30F8.8 Caenorhabditis elegans slow growth wormbase
YBR198C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_160940 (Schistosoma mansoni), hypothetical protein
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