Detailed view for Smp_070760

Basic information

TDR Targets ID: 295679
Schistosoma mansoni, gas41
Source Database / ID:  GeneDB

pI: 7.1184 | Length (AA): 223 | MW (Da): 25760 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03366   YEATS family

Gene Ontology

Mouse over links to read term descriptions.
GO:0035267   NuA4 histone acetyltransferase complex  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0000812   SWR1 complex  
GO:0005634   nucleus  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 146 5xtz (D) 9 153 55.00 0 1 1.27081 -0.43
10 115 5iql (A) 203 311 42.00 0 1 1.01604 -0.68
183 220 4ilo (A) 47 84 16.00 0.84 0.01 0.369504 -0.65
186 215 4r4m (A) 15 44 27.00 0.3 0.01 0.393629 -0.15
189 222 4tko (B) 213 246 29.00 0.36 0.05 0.356566 0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128501)

Species Accession Gene Product
Arabidopsis thaliana AT2G18000   TBP-associated factor 14
Arabidopsis thaliana AT5G45600   GAS 41-like protein
Babesia bovis BBOV_III008280   YEATS family protein
Brugia malayi Bm1_14845   Hypothetical 26.0 kDa protein in CYB5-LEU4 intergenic region
Candida albicans CaO19.5501   similar to human AF9, PFAM YEATS family
Candida albicans CaO19_5501   hypothetical protein
Caenorhabditis elegans CELE_M04B2.3   Protein GFL-1
Cryptosporidium hominis Chro.20029   Gas41
Cryptosporidium parvum cgd2_220   transcription factor TFIIF
Dictyostelium discoideum DDB_G0279563   hypothetical protein
Drosophila melanogaster Dmel_CG9207   CG9207 gene product from transcript CG9207-RA
Echinococcus granulosus EgrG_001012100   YEATS domain containing protein
Entamoeba histolytica EHI_088040   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001012100   YEATS domain containing protein
Homo sapiens ENSG00000127337   YEATS domain containing 4
Loa Loa (eye worm) LOAG_12836   hypothetical protein
Mus musculus ENSMUSG00000020171   YEATS domain containing 4
Neospora caninum NCLIV_052600   YEATS family protein, related
Oryza sativa 4340047   Os06g0137300
Plasmodium berghei PBANKA_1223600   YEATS domain-containing protein, putative
Plasmodium falciparum PF3D7_0807000   YEATS domain-containing protein, putative
Plasmodium knowlesi PKNH_0111800   YEATS domain-containing protein, putative
Plasmodium vivax PVX_088195   hypothetical protein, conserved
Plasmodium yoelii PY07255   hypothetical protein
Saccharomyces cerevisiae YNL107W   Yaf9p
Schistosoma japonicum Sjp_0068080   YEATS domain-containing protein 4, putative
Schistosoma mansoni Smp_116780   gas41
Schistosoma mansoni Smp_070760   gas41
Schmidtea mediterranea mk4.003786.00   Putative gas41
Schmidtea mediterranea mk4.004283.06   Putative gas41
Toxoplasma gondii TGME49_215730   Gas41, putative
Theileria parva TP04_0728   Gas41, putative
Trichomonas vaginalis TVAG_008740   gas41, putative
Trichomonas vaginalis TVAG_340920   yeats domain, putative

Essentiality

Smp_070760 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_M04B2.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_M04B2.3 Caenorhabditis elegans larval lethal wormbase
PBANKA_1223600 Plasmodium berghei Essential plasmo
TGME49_215730 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_070760 (Schistosoma mansoni), gas41
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