Detailed view for Smp_157970

Basic information

TDR Targets ID: 295719
Schistosoma mansoni, 60S ribosomal protein L7a
Source Database / ID:  GeneDB

pI: 10.2457 | Length (AA): 943 | MW (Da): 107923 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01248   Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
PF02862   DDHD domain

Gene Ontology

Mouse over links to read term descriptions.
GO:1990904   GO:ribonucleoprotein complex  

GO:0046872   metal ion binding  
GO:0042254   ribosome biogenesis and assembly  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
634 791 4uos (A) 6 160 23.00 0.75 0.26 0.38685 -0.41
778 905 2ozb (A) 9 125 26.00 0 1 0.487937 -1.19
796 900 4bw0 (B) 11 115 36.00 0.00000034 1 0.712247 -1.55
807 915 2fc3 (A) 26 126 36.00 0 1 0.536789 -0.73
807 905 2czw (A) 27 121 36.00 0 1 0.586184 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126938)

Species Accession Gene Product
Arabidopsis thaliana AT3G62870   60S ribosomal protein L7a-2
Arabidopsis thaliana AT2G47610   60S ribosomal protein L7a-1
Babesia bovis BBOV_III010580   ribosomal protein L7Ae family protein
Brugia malayi Bm1_21735   60S ribosomal protein L7a
Brugia malayi Bm1_16165   60S ribosomal protein L7a
Candida albicans CaO19.2311   one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subuni
Candida albicans CaO19.6002   one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subuni
Candida albicans CaO19.13423   one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subuni
Candida albicans CaO19.9847   one of two genes for likely cytosolic ribosomal protein similar to S. cerevisiae RPL8A (YLL045C) and RPL8B YHL033C) large subuni
Caenorhabditis elegans CELE_Y24D9A.4   Protein RPL-7A, isoform C
Cryptosporidium hominis Chro.80055   60S ribosomal protein L7A
Cryptosporidium parvum cgd8_430   60S ribosomal protein L7A
Dictyostelium discoideum DDB_G0277629   60S ribosomal protein L7a
Drosophila melanogaster Dmel_CG3314   Ribosomal protein L7A
Echinococcus granulosus EgrG_000887400   ribosomal protein l7a
Entamoeba histolytica EHI_029530   60S ribosomal protein L7a, putative
Entamoeba histolytica EHI_103310   60S ribosomal protein L7a, putative
Entamoeba histolytica EHI_169360   60S ribosomal protein L7a, putative
Entamoeba histolytica EHI_035090   60S ribosomal protein L7a, putative
Echinococcus multilocularis EmuJ_000887400   ribosomal protein l7a
Giardia lamblia GL50803_17244   Ribosomal protein L7a
Homo sapiens ENSG00000148303   ribosomal protein L7a
Leishmania braziliensis LbrM.07.0560   60S ribosomal protein L7a, putative
Leishmania braziliensis LbrM.07.0570   60S ribosomal protein L7a, putative
Leishmania donovani LdBPK_070550.1   60S ribosomal protein L7a, putative
Leishmania infantum LinJ.07.0550   60S ribosomal protein L7a, putative
Leishmania infantum LinJ.07.0560   60S ribosomal protein L7a, putative
Leishmania major LmjF.07.0500   60S ribosomal protein L7a, putative
Leishmania major LmjF.07.0510   60S ribosomal protein L7a, putative
Leishmania mexicana LmxM.07.0500   60S ribosomal protein L7a, putative
Leishmania mexicana LmxM.07.0510   60S ribosomal protein L7a, putative
Loa Loa (eye worm) LOAG_03794   60S ribosomal protein L7a
Mus musculus ENSMUSG00000062647   ribosomal protein L7A
Neospora caninum NCLIV_025920   hypothetical protein
Oryza sativa 4345279   Os08g0326400
Oryza sativa 4347522   Os09g0507800
Onchocerca volvulus OVOC2749   60S ribosomal protein L7a homolog
Plasmodium berghei PBANKA_1019400   60S ribosomal protein L7-3, putative
Plasmodium falciparum PF3D7_1424400   60S ribosomal protein L7-3, putative
Plasmodium knowlesi PKNH_1333700   ribosomal protein L7A, putative
Plasmodium vivax PVX_085270   ribosomal protein L7A, putative
Plasmodium yoelii PY06460   60S ribosomal protein L7a
Saccharomyces cerevisiae YHL033C   ribosomal 60S subunit protein L8A
Saccharomyces cerevisiae YLL045C   ribosomal 60S subunit protein L8B
Schistosoma japonicum Sjp_0300500   ko:K01066 esterase / lipase [EC3.1.1.-], putative
Schistosoma japonicum Sjp_0208360   ko:K02936 large subunit ribosomal protein L7Ae, putative
Schistosoma mansoni Smp_157970   60S ribosomal protein L7a
Schistosoma mansoni Smp_177210   60S ribosomal protein L7a
Schmidtea mediterranea mk4.000051.02   60S ribosomal protein L7a
Trypanosoma brucei gambiense Tbg972.8.885   60S ribosomal protein L7a, putative
Trypanosoma brucei gambiense Tbg972.8.880   60S ribosomal protein L7a, putative
Trypanosoma brucei Tb927.8.1340   60S ribosomal protein L7a, putative
Trypanosoma brucei Tb927.8.1330   60S ribosomal protein L7a, putative
Trypanosoma congolense TcIL3000_0_39600   60S ribosomal protein L7a, putative
Trypanosoma congolense TcIL3000_0_39590   60S ribosomal protein L7a, putative
Trypanosoma congolense TcIL3000_0_27750   60S ribosomal protein L7a, putative
Trypanosoma cruzi TcCLB.506401.320   60S ribosomal protein L7a, putative
Trypanosoma cruzi TcCLB.510835.40   60S ribosomal protein L7a, putative
Toxoplasma gondii TGME49_261570   ribosomal protein RPL7A
Theileria parva TP02_0083   60S ribosomal protein L7a, putative
Trichomonas vaginalis TVAG_274830   60S ribosomal protein L7a, putative
Trichomonas vaginalis TVAG_199270   60S ribosomal protein L7a, putative
Trichomonas vaginalis TVAG_221870   60S ribosomal protein L7a, putative
Trichomonas vaginalis TVAG_009840   60S ribosomal protein L7a, putative

Essentiality

Smp_157970 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.1330 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.1330 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.1330 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.1330 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y24D9A.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y24D9A.4 Caenorhabditis elegans larval arrest wormbase
CELE_Y24D9A.4 Caenorhabditis elegans slow growth wormbase
CELE_Y24D9A.4 Caenorhabditis elegans sterile wormbase
TGME49_261570 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_157970 (Schistosoma mansoni), 60S ribosomal protein L7a
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