Detailed view for Smp_140520.2

Basic information

TDR Targets ID: 295820
Schistosoma mansoni, ank repeat-containing
Source Database / ID:  GeneDB

pI: 6.6042 | Length (AA): 1781 | MW (Da): 199342 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12796   Ankyrin repeats (3 copies)
PF13637   Ankyrin repeats (many copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
737 853 5z2m (B) 1 105 25.00 0.00000015 1 0.347093 -0.72
750 853 3c5r (A) 0 518 31.00 0.00000000028 1 0.474794 -0.97
773 877 1uoh (A) 16 121 34.00 0.0000000083 1 0.596356 -1.08
773 1425 4rlv (A) 2074 2723 15.00 0.0000000000069 1 0.550048 0.56
798 855 2eta (A) 166 236 22.00 0.43 0.96 0.351966 -1.34
823 1018 2f8y (A) 1923 2114 34.00 0 1 0.586651 -0.79
828 957 1n0r (A) 1 125 51.00 0 1 0.731593 -1.01
887 970 3deo (A) 152 231 40.00 0.000027 1 0.612765 -1.48
1252 1475 3kea (A) 49 275 25.00 0.69 1 0.290372 0.13
1299 1469 3d9h (A) 37 209 17.00 0.0000004 0.39 0.319413 -0.35
1332 1469 4oau (C) 60 197 21.00 0.00000071 0.89 0.393885 -0.38
1334 1469 4o60 (A) 74 213 28.00 0 0.72 0.431762 -0.54
1334 1458 6fes (A) 50 180 28.00 0 0.82 0.438585 -0.57
1334 1467 5ma5 (C) 50 197 28.00 0 0.89 0.462639 -0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131598)

Species Accession Gene Product
Brugia malayi Bm1_09655   Ankyrin homolog precursor
Caenorhabditis elegans CELE_T28D6.4   Protein T28D6.4
Drosophila melanogaster Dmel_CG10011   CG10011 gene product from transcript CG10011-RA
Echinococcus granulosus EgrG_001099500   ankyrin repeat domain containing protein 50
Echinococcus granulosus EgrG_001201800   ankyrin domain repeat containing protein
Echinococcus multilocularis EmuJ_001099500   ankyrin repeat domain containing protein 50
Giardia lamblia GL50803_114671   Protein 21.1
Giardia lamblia GL50803_10744   Kinase, NEK
Homo sapiens ENSG00000151458   ankyrin repeat domain 50
Loa Loa (eye worm) LOAG_15521   hypothetical protein
Loa Loa (eye worm) LOAG_12449   hypothetical protein
Loa Loa (eye worm) LOAG_13408   hypothetical protein
Loa Loa (eye worm) LOAG_16031   hypothetical protein
Loa Loa (eye worm) LOAG_14446   hypothetical protein
Oryza sativa 4333611   Os03g0655500
Onchocerca volvulus OVOC9615  
Schistosoma japonicum Sjp_0116550   hypothetical protein
Schistosoma japonicum Sjp_0091200   Ankyrin-1, putative
Schistosoma mansoni Smp_140520.2   ank repeat-containing
Schistosoma mansoni Smp_140520.1   ank repeat-containing
Schmidtea mediterranea mk4.001311.06   Si:dkey-145p14.5 protein
Schmidtea mediterranea mk4.014341.00  
Schmidtea mediterranea mk4.001311.08  
Schmidtea mediterranea mk4.001311.07  

Essentiality

Smp_140520.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T28D6.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_140520.2 (Schistosoma mansoni), ank repeat-containing
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