Detailed view for Smp_153990

Basic information

TDR Targets ID: 295887
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 5.5555 | Length (AA): 717 | MW (Da): 80986 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00412   LIM domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
259 717 4n5a (A) 21 511 9.00 0 0.09 0.635667 -0.04
448 514 2lzu (A) 40 106 43.00 0 0.79 0.513945 0.36
448 503 2d8x (A) 5 59 25.00 0 0.52 0.305603 0.04
451 502 2co8 (A) 18 71 40.00 0.00015 0.98 0.473324 0.57
575 658 1mey (C) 2 84 11.00 0.11 0 0.174155 -0.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128738)

Species Accession Gene Product
Arabidopsis thaliana AT1G01780   LIM family protein
Arabidopsis thaliana AT3G55770   actin bundler LIM family protein WLIM2b
Arabidopsis thaliana AT2G39900   protein WLIM2A
Caenorhabditis elegans CELE_T04C9.4   Protein MLP-1, isoform C
Dictyostelium discoideum DDB_G0290575   LIM-type zinc finger-containing protein
Drosophila melanogaster Dmel_CG42309   Muscle LIM protein at 60A
Drosophila melanogaster Dmel_CG1019   Muscle LIM protein at 84B
Echinococcus granulosus EgrG_000325700   protein MICAL 3
Echinococcus granulosus EgrG_000893500   cysteine and glycine rich protein 1
Echinococcus multilocularis EmuJ_000893500   cysteine and glycine rich protein 1
Echinococcus multilocularis EmuJ_000325700   protein MICAL 3
Homo sapiens ENSG00000175183   cysteine and glycine-rich protein 2
Homo sapiens ENSG00000129170   cysteine and glycine-rich protein 3 (cardiac LIM protein)
Homo sapiens ENSG00000159176   cysteine and glycine-rich protein 1
Loa Loa (eye worm) LOAG_14746   mlp/crp family protein 1
Loa Loa (eye worm) LOAG_02013   hypothetical protein
Loa Loa (eye worm) LOAG_12769   mlp/crp family protein 1
Mus musculus ENSMUSG00000026421   cysteine and glycine-rich protein 1
Mus musculus ENSMUSG00000020186   cysteine and glycine-rich protein 2
Mus musculus ENSMUSG00000030470   cysteine and glycine-rich protein 3
Oryza sativa 4330114   Os02g0641000
Oryza sativa 4336498   Os04g0532500
Oryza sativa 4349048   Os10g0503100
Oryza sativa 4332355   Os03g0266100
Schistosoma japonicum Sjp_0312240   IPR001781,LIM, zinc-binding,domain-containing
Schistosoma japonicum Sjp_0202230   ko:K09377 cysteine and glycine-rich protein, putative
Schistosoma japonicum Sjp_0070980   IPR001781,LIM, zinc-binding,domain-containing
Schistosoma mansoni Smp_087250   crp1/csrp1/crip1
Schistosoma mansoni Smp_153990   hypothetical protein
Schmidtea mediterranea mk4.002827.00  
Schmidtea mediterranea mk4.008271.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_153990 (Schistosoma mansoni), hypothetical protein
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