pI: 6.9613 |
Length (AA): 359 |
MW (Da): 39400 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
15 | 314 | 5ltg (A) | 34 | 296 | 37.00 | 0 | 1 | 1.07615 | -0.19 |
20 | 327 | 3vu4 (B) | 22 | 298 | 32.00 | 0 | 1 | 0.931439 | 0.18 |
178 | 230 | 4l3r (A) | 81 | 131 | 16.00 | 0 | 0.01 | 0.336332 | -1.36 |
243 | 323 | 3ow8 (A) | 151 | 228 | 35.00 | 0.51 | 1 | 0.746127 | -1.09 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128185)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G40810 | ATG18c-like protein |
Arabidopsis thaliana | AT3G56440 | autophagy-related protein 18D |
Arabidopsis thaliana | AT3G62770 | autophagy-related protein 18a |
Babesia bovis | BBOV_IV003010 | conserved hypothetical protein |
Brugia malayi | Bm1_40050 | Hypothetical 51.2 kDa protein in PET54-DIE2 intergenic region |
Candida albicans | CaO19.1793 | potential WD40, G-beta repeat |
Candida albicans | CaO19.9359 | potential WD40, G-beta repeat |
Dictyostelium discoideum | DDB_G0282581 | WD repeat domain phosphoinositide-interacting protein 3 |
Drosophila melanogaster | Dmel_CG11975 | CG11975 gene product from transcript CG11975-RB |
Echinococcus granulosus | EgrG_000168900 | WD40 repeat domain containing protein |
Entamoeba histolytica | EHI_121490 | WD repeat protein |
Entamoeba histolytica | EHI_099190 | WD repeat protein |
Echinococcus multilocularis | EmuJ_000168900 | WD40 repeat domain containing protein |
Giardia lamblia | GL50803_10822 | WD-40 repeat protein family |
Homo sapiens | ENSG00000141580 | WD repeat domain 45B |
Loa Loa (eye worm) | LOAG_13735 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10619 | hypothetical protein |
Mus musculus | ENSMUSG00000025173 | WD repeat domain 45B |
Neospora caninum | NCLIV_041070 | hypothetical protein |
Neospora caninum | NCLIV_012290 | hypothetical protein |
Oryza sativa | 4325192 | Os01g0168500 |
Oryza sativa | 4326829 | Os01g0934000 |
Onchocerca volvulus | OVOC5146 |
|
Plasmodium berghei | PBANKA_1211300 | autophagy-related protein 18, putative |
Plasmodium falciparum | PF3D7_1012900 | autophagy-related protein 18, putative |
Plasmodium knowlesi | PKNH_0812700 | autophagy-related protein 18, putative |
Plasmodium vivax | PVX_094865 | autophagy-related protein 18, putative |
Plasmodium yoelii | PY01361 | hypothetical protein |
Saccharomyces cerevisiae | YGR223C | Hsv2p |
Schistosoma japonicum | Sjp_0021750 | IPR001680,WD-40 repeat;IPR011046,WD40-like,domain-containing |
Schistosoma mansoni | Smp_154110 | hypothetical protein |
Schmidtea mediterranea | mk4.018867.00 | WD repeat domain phosphoinositide-interacting protein 3 |
Toxoplasma gondii | TGME49_220160 | WD domain-containing protein |
Toxoplasma gondii | TGME49_288600 | WD domain, G-beta repeat-containing protein |
Theileria parva | TP01_0622 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_260770 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_406410 | WD repeat domain phosphoinositide-interacting protein, putative |
Trichomonas vaginalis | TVAG_008820 | WD repeat domain phosphoinositide-interacting protein, putative |
Trichomonas vaginalis | TVAG_033010 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1211300 | Plasmodium berghei | Essential | plasmo |
TGME49_288600 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_220160 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_288600 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_220160 | Toxoplasma gondii | Probably non-essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.