Detailed view for Smp_142770

Basic information

TDR Targets ID: 295923
Schistosoma mansoni, importin-beta 2
Source Database / ID:  GeneDB

pI: 4.7652 | Length (AA): 869 | MW (Da): 98189 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03810   Importin-beta N-terminal domain
PF13513   HEAT-like repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0008536   Ran GTPase binding  
GO:0005737   cytoplasm  
GO:0005643   nuclear pore  
GO:0005634   nucleus  
GO:0008565   protein transporter activity  
GO:0005488   binding  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 868 1qbk (B) 4 871 63.00 0 1 1.70594 -0.16
35 762 3w5k (A) 16 749 17.00 0 1 0.971745 0.08
134 285 3sl9 (A) 150 299 11.00 0 0.85 0.483914 -1.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127643)

Species Accession Gene Product
Arabidopsis thaliana AT2G16950   transportin 1
Babesia bovis BBOV_II003640   transportin, putative
Brugia malayi Bm1_44175   Importin-beta N-terminal domain containing protein
Candida albicans CaO19.3556   Karyopherin/transportin
Caenorhabditis elegans CELE_R06A4.4   Protein IMB-2, isoform A
Cryptosporidium hominis Chro.80396   karyopherin (importin) beta 2
Cryptosporidium parvum cgd8_3440   importin beta like ARM repeat alpha superhelix
Dictyostelium discoideum DDB_G0269948   hypothetical protein
Drosophila melanogaster Dmel_CG8219   CG8219 gene product from transcript CG8219-RA
Drosophila melanogaster Dmel_CG7398   Transportin
Echinococcus granulosus EgrG_000427400   transportin 1
Entamoeba histolytica EHI_060990   HEAT repeat domain containing protein
Echinococcus multilocularis EmuJ_000427400   transportin 1
Homo sapiens 3842   transportin 1
Homo sapiens ENSG00000105576   transportin 2
Leishmania braziliensis LbrM.34.2280   hypothetical protein, conserved
Leishmania donovani LdBPK_352380.1   Importin 1
Leishmania infantum LinJ.35.2380   hypothetical protein, conserved
Leishmania major LmjF.35.2330   hypothetical protein, conserved
Leishmania mexicana LmxM.34.2330   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_12124   importin-beta domain-containing protein
Loa Loa (eye worm) LOAG_13613   Tnpo1 protein
Mus musculus ENSMUSG00000031691   transportin 2 (importin 3, karyopherin beta 2b)
Mus musculus ENSMUSG00000009470   transportin 1
Neospora caninum NCLIV_059680   CBR-IMB-2 protein, related
Oryza sativa 4337505   Os04g0691500
Plasmodium berghei PBANKA_1126400   transportin, putative
Plasmodium falciparum PF3D7_0627700   transportin
Plasmodium knowlesi PKNH_1122100   transportin, putative
Plasmodium vivax PVX_114490   transportin, putative
Plasmodium yoelii PY02706   transportin-related
Saccharomyces cerevisiae YBR017C   Kap104p
Schistosoma japonicum Sjp_0214200   Transportin-1, putative
Schistosoma mansoni Smp_142770   importin-beta 2
Schmidtea mediterranea mk4.001891.03  
Schmidtea mediterranea mk4.001891.02  
Schmidtea mediterranea mk4.001891.00  
Schmidtea mediterranea mk4.001891.04  
Trypanosoma brucei gambiense Tbg972.9.8490   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.13520   Importin 1
Trypanosoma cruzi TcCLB.510655.90   Importin 1
Toxoplasma gondii TGME49_216590   HEAT repeat-containing protein
Theileria parva TP04_0218   transportin, putative

Essentiality

Smp_142770 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.4360 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.4360 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.4360 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.4360 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R06A4.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_R06A4.4 Caenorhabditis elegans larval arrest wormbase
CELE_R06A4.4 Caenorhabditis elegans larval lethal wormbase
CELE_R06A4.4 Caenorhabditis elegans slow growth wormbase
PBANKA_1126400 Plasmodium berghei Essential plasmo
TGME49_216590 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_142770 (Schistosoma mansoni), importin-beta 2
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