Detailed view for Smp_011570.1

Basic information

TDR Targets ID: 295931
Schistosoma mansoni, 40S ribosomal protein S4
Source Database / ID:  GeneDB

pI: 11.0768 | Length (AA): 264 | MW (Da): 30377 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00467   KOW motif
PF00900   Ribosomal family S4e
PF01479   S4 domain
PF08071   RS4NT (NUC023) domain
PF16121   40S ribosomal protein S4 C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 263 4kzy (E) 2 262 70.00 0 1 1.82124 -0.39
39 237 3kbg (A) 34 227 34.00 0 1 1.21139 -0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126890)

Species Accession Gene Product
Arabidopsis thaliana AT2G17360   40S ribosomal protein S4-1
Arabidopsis thaliana AT5G58420   40S ribosomal protein S4-3
Babesia bovis BBOV_III007530   ribosomal protein S4e, putative
Brugia malayi Bm1_06615   40S ribosomal protein S4
Candida albicans CaO19.5341   one of two genes for cytosolic ribosomal protein S4 (formerly S7) - this one has no intron
Candida albicans CaO19.10862   one of two genes for cytosolic ribosomal protein S4 (formerly S7) - this one has an intron
Candida albicans CaO19.12801   one of two genes for cytosolic ribosomal protein S4 (formerly S7) - this one has no intron
Candida albicans CaO19.3354   one of two genes for cytosolic ribosomal protein S4 (formerly S7) - this one has an intron
Caenorhabditis elegans CELE_Y43B11AR.4   Protein RPS-4
Cryptosporidium hominis Chro.70527   40S ribosomal protein S4
Cryptosporidium parvum cgd7_4760   ribosomal protein S4, putative
Dictyostelium discoideum DDB_G0272825   40S ribosomal protein S4
Drosophila melanogaster Dmel_CG11276   Ribosomal protein S4
Echinococcus granulosus EgrG_000644800   ribosomal protein S4
Entamoeba histolytica EHI_118170   ribosomal protein S4, putative
Entamoeba histolytica EHI_008210   ribosomal protein S4, putative
Entamoeba histolytica EHI_098840   ribosomal protein S4, putative
Entamoeba histolytica EHI_003940   ribosomal protein S4, putative
Entamoeba histolytica EHI_057850   40S ribosomal protein S4, putative
Echinococcus multilocularis EmuJ_000644800   ribosomal protein S4
Giardia lamblia GL50803_11359   Ribosomal protein S4
Homo sapiens ENSG00000279950   ribosomal protein S4, Y-linked 1
Homo sapiens 6191   ribosomal protein S4, X-linked
Leishmania braziliensis LbrM.13.1000   40S ribosomal protein S4, putative
Leishmania donovani LdBPK_131130.1   40S ribosomal protein S4, putative
Leishmania donovani LdBPK_131120.1   40S ribosomal protein S4, putative
Leishmania infantum LinJ.13.1130   40S ribosomal protein S4, putative
Leishmania infantum LinJ.13.1120   40S ribosomal protein S4, putative
Leishmania major LmjF.13.1220   40S ribosomal protein S4, putative
Leishmania major LmjF.13.1230   40S ribosomal protein S4, putative
Leishmania mexicana LmxM.13.1230   40S ribosomal protein S4, putative
Leishmania mexicana LmxM.13.1220   40S ribosomal protein S4, putative
Loa Loa (eye worm) LOAG_05603   40S ribosomal protein S4
Mus musculus ENSMUSG00000031320   ribosomal protein S4, X-linked
Neospora caninum NCLIV_002520   hypothetical protein
Oryza sativa 4338571   Os05g0368300
Oryza sativa 4326022   Os01g0358400
Oryza sativa 4328016   Os02g0105900
Plasmodium berghei PBANKA_0941500   40S ribosomal protein S4, putative
Plasmodium falciparum PF3D7_1105400   40S ribosomal protein S4, putative
Plasmodium knowlesi PKNH_0903000   40S ribosomal protein S4, putative
Plasmodium vivax PVX_090950   40S ribosomal protein S4, putative
Plasmodium yoelii PY03779   ribosomal protein S4 X isoform
Saccharomyces cerevisiae YHR203C   ribosomal 40S subunit protein S4B
Saccharomyces cerevisiae YJR145C   ribosomal 40S subunit protein S4A
Schistosoma japonicum Sjp_0005660   ko:K02987 small subunit ribosomal protein S4e, putative
Schistosoma mansoni Smp_011570.2   40S ribosomal protein S4
Schistosoma mansoni Smp_011570.1   40S ribosomal protein S4
Schmidtea mediterranea mk4.000705.05   40S ribosomal protein S4
Schmidtea mediterranea mk4.000449.07  
Schmidtea mediterranea mk4.000449.06   40S ribosomal protein S4
Schmidtea mediterranea mk4.003233.00   40S ribosomal protein S4
Schmidtea mediterranea mk4.000705.06  
Schmidtea mediterranea mk4.000763.09   40S ribosomal protein S4
Trypanosoma brucei gambiense Tbg972.11.4100   40S ribosomal protein S4, putative
Trypanosoma brucei gambiense Tbg972.11.4090   40S ribosomal protein S4, putative
Trypanosoma brucei Tb927.11.3600   40S ribosomal protein S4, putative
Trypanosoma congolense TcIL3000_0_55320   Ribosomal family S4e/KOW motif containing protein, putative
Trypanosoma congolense TcIL3000_0_55310   40S ribosomal protein S4, putative
Trypanosoma congolense TcIL3000.11.3560   40S ribosomal protein S4, putative
Trypanosoma cruzi TcCLB.509683.117   40S ribosomal protein S4, putative
Trypanosoma cruzi TcCLB.511051.39   40S ribosomal protein S4, putative
Trypanosoma cruzi TcCLB.511051.50   40S ribosomal protein S4, putative
Theileria parva TP04_0680   40S ribosomal protein S4, putative
Trichomonas vaginalis TVAG_098430   30S/40S ribosomal protein S4, putative
Trichomonas vaginalis TVAG_379260   30S ribosomal protein S4e, putative
Trichomonas vaginalis TVAG_335480   30S ribosomal protein S4e, putative
Trichomonas vaginalis TVAG_239500   40S ribosomal protein S4, putative
Trichomonas vaginalis TVAG_098450   40S ribosomal protein S4, putative
Trichomonas vaginalis TVAG_583060   30S/40S ribosomal protein S4, putative
Trichomonas vaginalis TVAG_131210   30S ribosomal protein S4e, putative

Essentiality

Smp_011570.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y43B11AR.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y43B11AR.4 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_011570.1 (Schistosoma mansoni), 40S ribosomal protein S4
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