Detailed view for Smp_082990

Basic information

TDR Targets ID: 295944
Schistosoma mansoni, cornichon
Source Database / ID:  GeneDB

pI: 6.444 | Length (AA): 144 | MW (Da): 16561 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03311   Cornichon protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0016192   vesicle-mediated transport  
GO:0007242   intracellular signaling cascade  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 144 5y78 (A) 190 348 30.00 0.91 0.16 0.9529 1.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127951)

Species Accession Gene Product
Arabidopsis thaliana AT1G12390   protein cornichon-4
Arabidopsis thaliana AT1G12340   putative protein cornichon
Arabidopsis thaliana AT4G12090   Cornichon family protein
Arabidopsis thaliana AT3G12180   protein cornichon-like1
Brugia malayi Bm1_51875   Cornichon protein
Candida albicans CaO19.6787   14 KDa protein found on ER-derived vesicles
Candida albicans CaO19.14079   14 KDa protein found on ER-derived vesicles
Caenorhabditis elegans CELE_T09E8.3   Protein CNIH-2
Dictyostelium discoideum DDB_G0279785   hypothetical protein
Dictyostelium discoideum DDB_G0270698   hypothetical protein
Drosophila melanogaster Dmel_CG5855   cornichon
Drosophila melanogaster Dmel_CG17262   cornichon related
Echinococcus granulosus EgrG_000116300   cornichon
Entamoeba histolytica EHI_049050   hypothetical protein
Echinococcus multilocularis EmuJ_000116300   cornichon
Homo sapiens ENSG00000143771   cornichon family AMPA receptor auxiliary protein 4
Homo sapiens 10175   cornichon family AMPA receptor auxiliary protein 1
Loa Loa (eye worm) LOAG_03291   hypothetical protein
Mus musculus ENSMUSG00000015759   cornichon homolog 1 (Drosophila)
Mus musculus ENSMUSG00000062169   cornichon homolog 4 (Drosophila)
Mus musculus 102634663   predicted gene, 32195
Oryza sativa 4340041   Os06g0136500
Oryza sativa 4352293   Os12g0506400
Onchocerca volvulus OVOC6796   Protein cornichon homolog
Saccharomyces cerevisiae YGL054C   Erv14p
Schistosoma japonicum Sjp_0205420   Protein cornichon, putative
Schistosoma mansoni Smp_082990   cornichon
Schmidtea mediterranea mk4.000323.21   Protein cornichon
Trichomonas vaginalis TVAG_119630   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_082990 (Schistosoma mansoni), cornichon
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