Detailed view for LmjF.24.1190

Basic information

TDR Targets ID: 29595
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.2217 | Length (AA): 313 | MW (Da): 33300 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01027   Inhibitor of apoptosis-promoting Bax1

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 106 2mqa (A) 19 99 10.00 0 0.02 0.377786 -0.48
99 226 5i20 (A) 25 163 34.00 0.00074 0.16 0.307846 2.52
109 311 4pgr (A) 10 210 19.00 0 0.34 0.818562 -0.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129362)

Species Accession Gene Product
Arabidopsis thaliana AT5G47120   BAX inhibitor 1
Babesia bovis BBOV_I000430   Bax inhibitor-1, putative
Brugia malayi Bm1_27535   Uncharacterized protein family UPF0005 containing protein
Cryptosporidium hominis Chro.60342   bax inhibitor-1
Cryptosporidium parvum cgd6_2960   Bax inhibitor-1 (BI-1). integral membrane protien with 6 or more transmembrane domains
Dictyostelium discoideum DDB_G0287617   hypothetical protein
Drosophila melanogaster Dmel_CG7188   Bax Inhibitor-1
Escherichia coli b0970   HflBKC-binding inner membrane protein, UPF0005 family
Echinococcus granulosus EgrG_001071100   Bax inhibitor 1
Entamoeba histolytica EHI_169290   Bax inhibitor, putative
Echinococcus multilocularis EmuJ_001071100   Bax inhibitor 1
Homo sapiens ENSG00000139644   transmembrane BAX inhibitor motif containing 6
Leishmania braziliensis LbrM.24.1210   hypothetical protein, conserved
Leishmania donovani LdBPK_241220.1   Inhibitor of apoptosis-promoting Bax1, putative
Leishmania infantum LinJ.24.1220   hypothetical protein, conserved
Leishmania major LmjF.24.1190   hypothetical protein, conserved
Leishmania mexicana LmxM.24.1190   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_10136   bax inhibitor I
Mus musculus ENSMUSG00000023010   transmembrane BAX inhibitor motif containing 6
Neospora caninum NCLIV_029150   Bax inhibitor 1, related
Oryza sativa 4328149   Os02g0125300
Onchocerca volvulus OVOC408   Bax inhibitor 1 homolog
Plasmodium berghei PBANKA_1323400   bax inhibitor 1, putative
Plasmodium falciparum PF3D7_1459800   bax inhibitor 1, putative
Plasmodium knowlesi PKNH_1222000   bax inhibitor 1, putative
Plasmodium vivax PVX_117470   bax inhibitor 1, putative
Plasmodium yoelii PY05517   hypothetical protein
Plasmodium yoelii PY05518   hypothetical protein
Schistosoma japonicum Sjp_0304850   Bax inhibitor 1, putative
Schistosoma mansoni Smp_044000   bax inhibitor
Schmidtea mediterranea mk4.000101.21   Bax inhibitor 1
Schmidtea mediterranea mk4.026543.00  
Schmidtea mediterranea mk4.020363.00   Putative bax inhibitor
Trypanosoma brucei gambiense Tbg972.11.6570   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.5820   Inhibitor of apoptosis-promoting Bax1, putative
Trypanosoma congolense TcIL3000.11.6200   Inhibitor of apoptosis-promoting Bax1, putative
Trypanosoma congolense TcIL3000_0_42100   Inhibitor of apoptosis-promoting Bax1, putative
Trypanosoma congolense TcIL3000.11.6230   Inhibitor of apoptosis-promoting Bax1, putative
Trypanosoma congolense TcIL3000_0_02440   Inhibitor of apoptosis-promoting Bax1, putative
Trypanosoma cruzi TcCLB.503487.70   Inhibitor of apoptosis-promoting Bax1, putative
Trypanosoma cruzi TcCLB.508641.200   Inhibitor of apoptosis-promoting Bax1, putative
Toxoplasma gondii TGME49_255900   Bax inhibitor-1, putative
Toxoplasma gondii TGME49_255895   hypothetical protein
Theileria parva TP02_0920   hypothetical protein, conserved

Essentiality

LmjF.24.1190 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3570 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3570 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3570 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.3570 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b0970 Escherichia coli non-essential goodall
TGME49_255900 Toxoplasma gondii Probably non-essential sidik
TGME49_255895 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LmjF.24.1190 (Leishmania major), hypothetical protein, conserved
Title for this comment
Comment