Detailed view for Smp_010690

Basic information

TDR Targets ID: 295967
Schistosoma mansoni, arp2/3
Source Database / ID:  GeneDB

pI: 7.505 | Length (AA): 329 | MW (Da): 37726 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04045   Arp2/3 complex, 34 kD subunit p34-Arc

Gene Ontology

Mouse over links to read term descriptions.
GO:0034314   Arp2/3 complex-mediated actin nucleation  
GO:0005885   Arp2/3 protein complex  
GO:0015629   actin cytoskeleton  
GO:0005856   cytoskeleton  
GO:0030833   regulation of actin filament polymerization  
GO:0030041   actin filament polymerization  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 286 1k8k (D) 1 283 58.00 0 1 1.6009 -1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128966)

Species Accession Gene Product
Arabidopsis thaliana AT1G30825   actin-related protein C2A
Arabidopsis thaliana AT2G33385   actin-related protein C2B
Brugia malayi Bm1_30220   ARP2/3 complex 34 kDa subunit
Candida albicans CaO19.2437   Arp2/3 protein complex
Candida albicans CaO19.9973   Arp2/3 protein complex
Caenorhabditis elegans CELE_Y6D11A.2   Protein ARX-4
Dictyostelium discoideum DDB_G0282813   actin related protein 2/3 complex, 34 kDa subunit
Drosophila melanogaster Dmel_CG10954   Actin-related protein 2/3 complex, subunit 2
Echinococcus granulosus EgrG_000305600   expressed protein
Echinococcus granulosus EgrG_000359700   actin related protein 2:3 complex subunit 2
Entamoeba histolytica EHI_091250   ARP2/3 complex 34 kda subunit, putative
Entamoeba histolytica EHI_199690   ARP2/3 complex 34 kda subunit, putative
Echinococcus multilocularis EmuJ_000305600   expressed protein
Echinococcus multilocularis EmuJ_000359700   actin related protein 2:3 complex subunit 2
Homo sapiens ENSG00000163466   actin related protein 2/3 complex, subunit 2, 34kDa
Loa Loa (eye worm) LOAG_07408   hypothetical protein
Mus musculus ENSMUSG00000006304   actin related protein 2/3 complex, subunit 2
Oryza sativa 4336383   Os04g0512300
Oryza sativa 4324174   Os01g0654300
Saccharomyces cerevisiae YNR035C   Arc35p
Schistosoma japonicum Sjp_0303620   ko:K05758 actin related protein 2/3 complex, subunit 2, putative
Schistosoma mansoni Smp_010690   arp2/3
Schmidtea mediterranea mk4.000933.04   Probable actin-related protein 2/3 complex subunit 2
Trypanosoma brucei gambiense Tbg972.8.4170   ARP2/3 complex subunit, putative
Trypanosoma brucei Tb927.8.4410   ARP2/3 complex subunit, putative
Trypanosoma congolense TcIL3000_8_4160   ARP2/3 complex subunit, putative
Trypanosoma cruzi TcCLB.506865.10   ARP2/3 complex subunit, putative
Trypanosoma cruzi TcCLB.509569.90   ARP2/3 complex subunit, putative
Trichomonas vaginalis TVAG_087140   arp2/3, putative

Essentiality

Smp_010690 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.4410 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.4410 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.4410 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.4410 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y6D11A.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y6D11A.2 Caenorhabditis elegans larval arrest wormbase
CELE_Y6D11A.2 Caenorhabditis elegans sterile wormbase
YNR035C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_010690 (Schistosoma mansoni), arp2/3
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