Detailed view for Smp_006840

Basic information

TDR Targets ID: 295969
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.9173 | Length (AA): 127 | MW (Da): 13643 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132465)

Species Accession Gene Product
Arabidopsis thaliana AT1G30845   hypothetical protein
Caenorhabditis elegans CELE_F40F8.3   Protein F40F8.3
Dictyostelium discoideum DDB_G0268022   hypothetical protein
Drosophila melanogaster Dmel_CG42495   CG42495 gene product from transcript CG42495-RA
Echinococcus granulosus EgrG_001092800   expressed protein
Echinococcus multilocularis EmuJ_001092800   expressed protein
Homo sapiens ENSG00000169964   transmembrane protein 42
Leishmania braziliensis LbrM.32.2560   hypothetical protein, conserved
Leishmania donovani LdBPK_322480.1   hypothetical protein, conserved
Leishmania infantum LinJ.32.2480   hypothetical protein, conserved
Leishmania major LmjF.32.2330   hypothetical protein, conserved
Mus musculus ENSMUSG00000066233   transmembrane protein 42
Oryza sativa 4331476   Os03g0127000
Plasmodium berghei PBANKA_0910400   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1138300   conserved Plasmodium membrane protein, unknown function
Plasmodium knowlesi PKNH_0936500   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_092530   hypothetical protein, conserved
Plasmodium yoelii PY06418   hypothetical protein
Schistosoma japonicum Sjp_0070390   expressed protein
Schistosoma mansoni Smp_006840   hypothetical protein
Trypanosoma brucei gambiense Tbg972.11.17440   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.15540   hypothetical protein, conserved
Trypanosoma congolense TcIL3000.11.15600   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507129.40   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507969.70   hypothetical protein, conserved

Essentiality

Smp_006840 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.7180 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.7180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.7180 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.7180 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_006840 (Schistosoma mansoni), hypothetical protein
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