Detailed view for Smp_168480

Basic information

TDR Targets ID: 295989
Schistosoma mansoni, apoptosis inhibitor
Source Database / ID:  GeneDB

pI: 6.5678 | Length (AA): 615 | MW (Da): 69690 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01902   Diphthamide synthase
PF05918   Apoptosis inhibitory protein 5 (API5)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
75 552 1qbk (B) 284 764 13.00 0 1 0.866536 0.55
97 545 3u0r (A) 19 443 37.00 0 1 1.08838 -0.48
131 270 4k92 (A) 359 501 13.00 0 0.86 0.523942 -1.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131877)

Species Accession Gene Product
Arabidopsis thaliana AT1G29030   Apoptosis inhibitory protein 5
Arabidopsis thaliana AT2G34040   Apoptosis inhibitory protein 5
Brugia malayi Bm1_35085   api5-prov protein
Dictyostelium discoideum DDB_G0292876   hypothetical protein
Drosophila melanogaster Dmel_CG6582   CG6582 gene product from transcript CG6582-RA
Echinococcus granulosus EgrG_000788700   apoptosis inhibitor 5
Echinococcus multilocularis EmuJ_000788700   apoptosis inhibitor 5
Homo sapiens ENSG00000166181   apoptosis inhibitor 5
Loa Loa (eye worm) LOAG_10382   api5-prov protein
Mus musculus ENSMUSG00000027193   apoptosis inhibitor 5
Oryza sativa 4329135   Os02g0313400
Onchocerca volvulus OVOC5756   Apoptosis inhibitor 5 homolog
Schistosoma japonicum Sjp_0203750   Apoptosis inhibitor 5, putative
Schistosoma japonicum Sjp_0219240   expressed protein
Schistosoma mansoni Smp_168480   apoptosis inhibitor
Schmidtea mediterranea mk4.000007.14   Apoptosis inhibitor 5
Trichomonas vaginalis TVAG_436540   conserved hypothetical protein
Trichomonas vaginalis TVAG_244880   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_168480 (Schistosoma mansoni), apoptosis inhibitor
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