Detailed view for Smp_019980

Basic information

TDR Targets ID: 295990
Schistosoma mansoni, vacuole membrane protein
Source Database / ID:  GeneDB

pI: 8.4079 | Length (AA): 400 | MW (Da): 46048 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129330)

Species Accession Gene Product
Arabidopsis thaliana AT1G05360   protein KMS2
Arabidopsis thaliana AT4G14950   ER associated membrane protein KMS1
Brugia malayi Bm1_09750   RIKEN cDNA 4930579A11
Caenorhabditis elegans CELE_Y37D8A.22   Protein EPG-3
Cryptosporidium hominis Chro.50471   hypothetical protein
Cryptosporidium parvum cgd5_3820   vacuole membrane protein, VMP1 like integral membrane protein
Dictyostelium discoideum DDB_G0285175   TMEM49 family protein
Drosophila melanogaster Dmel_CG32087   CG32087 gene product from transcript CG32087-RA
Drosophila melanogaster Dmel_CG32675   Transport and Golgi organization 5
Echinococcus granulosus EgrG_000125700   vacuole membrane protein 1
Entamoeba histolytica EHI_027530   hypothetical protein
Echinococcus multilocularis EmuJ_000125700   vacuole membrane protein 1
Homo sapiens ENSG00000062716   vacuole membrane protein 1
Leishmania braziliensis LbrM.28.0740   hypothetical protein, conserved
Leishmania donovani LdBPK_280760.1   SNARE associated Golgi protein, putative
Leishmania infantum LinJ.28.0760   hypothetical protein, conserved
Leishmania major LmjF.28.0710   hypothetical protein, conserved
Leishmania mexicana LmxM.28.0710   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05994   hypothetical protein
Mus musculus ENSMUSG00000018171   vacuole membrane protein 1
Neospora caninum NCLIV_018930   GI15163, related
Oryza sativa 9267646   Os07g0571500
Oryza sativa 4326431   Os01g0778700
Plasmodium berghei PBANKA_1301600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1474600   conserved Plasmodium membrane protein, unknown function
Plasmodium knowlesi PKNH_1244900   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_118610   hypothetical protein, conserved
Plasmodium yoelii PY00265   TDC1, putative
Schistosoma japonicum Sjp_0051720   Transmembrane protein 49, putative
Schistosoma japonicum Sjp_0051690   Transmembrane protein 49, putative
Schistosoma mansoni Smp_019980   vacuole membrane protein
Schmidtea mediterranea mk4.020376.00   Ectopic P granules protein 3
Trypanosoma brucei gambiense Tbg972.11.9210   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.8060   SNARE associated Golgi protein, putative
Trypanosoma congolense TcIL3000.11.8570   SNARE associated Golgi protein, putative
Trypanosoma cruzi TcCLB.508815.80   SNARE associated Golgi protein, putative
Toxoplasma gondii TGME49_244370   TDC1, putative

Essentiality

Smp_019980 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.0480 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.0480 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.0480 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.0480 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y37D8A.22 Caenorhabditis elegans slow growth wormbase
TGME49_244370 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_019980 (Schistosoma mansoni), vacuole membrane protein
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