Detailed view for Smp_142220

Basic information

TDR Targets ID: 295991
Schistosoma mansoni, apobec-1 complementation factor
Source Database / ID:  GeneDB

pI: 6.9776 | Length (AA): 847 | MW (Da): 98623 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 141 6es4 (A) 88 241 45.00 0 1 0.666947 -1.18
63 130 4a8x (A) 159 228 28.00 0.1 0.87 0.506283 -0.89
67 135 4f25 (A) 101 168 25.00 0.72 0.96 0.502464 -0.95
67 250 5ifm (A) 76 248 27.00 0.011 1 0.380237 0.77
137 239 2dis (A) 1 103 71.00 0 1 0.796806 -0.06
294 780 4n5a (A) 36 544 9.00 0 0.02 0.48017 -0.02
651 791 2r4g (A) 296 443 28.00 0.66 0.1 0.0234699 1.13
671 779 3fsg (A) 144 260 29.00 0.71 0.11 0.183689 1.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_139955)

Species Accession Gene Product
Homo sapiens ENSG00000151962   RNA binding motif protein 46
Mus musculus ENSMUSG00000033882   RNA binding motif protein 46
Schistosoma japonicum Sjp_0122230   RNA-binding protein 47, putative
Schistosoma japonicum Sjp_0202040   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0087800   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0028580   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0011710   expressed protein
Schistosoma japonicum Sjp_0093570   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0118850   Probable RNA-binding protein 46, putative
Schistosoma japonicum Sjp_0004530   Probable RNA-binding protein 46, putative
Schistosoma japonicum Sjp_0205910   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0116490   Probable RNA-binding protein 46, putative
Schistosoma japonicum Sjp_0038690   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0091800   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0093730   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0011750   RNA-binding protein 47, putative
Schistosoma japonicum Sjp_0134160   hypothetical protein
Schistosoma japonicum Sjp_0317970   expressed protein
Schistosoma japonicum Sjp_0038350   APOBEC1 complementation factor, putative
Schistosoma japonicum Sjp_0133260   RNA-binding protein 47, putative
Schistosoma mansoni Smp_142220   apobec-1 complementation factor
Schmidtea mediterranea mk4.010433.01   Dead end protein homolog 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_142220 (Schistosoma mansoni), apobec-1 complementation factor
Title for this comment
Comment