pI: 9.5504 |
Length (AA): 442 |
MW (Da): 52461 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
51 | 160 | 2v1n (A) | 2 | 111 | 40.00 | 0 | 1 | 0.816069 | -0.82 |
269 | 442 | 4uos (A) | 1 | 173 | 9.00 | 0.0045 | 0.02 | 0.557565 | -1.22 |
321 | 438 | 2ckk (A) | 10 | 126 | 32.00 | 0 | 1 | 0.702168 | -0.3 |
383 | 438 | 3p8b (B) | 93 | 148 | 27.00 | 0.09 | 0.77 | 0.434897 | 0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Ring. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite, Male Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | early trophozoite, Female Gametocyte. | PlasmoDB Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_128587)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G55460 | DNA/RNA-binding protein Kin17 conserved region-containing protein |
Babesia bovis | BBOV_IV000850 | conserved hypothetical protein |
Brugia malayi | Bm1_30800 | Kin17 |
Candida albicans | CaO19.11298 | potential zinc finger protein similar to S. cerevisiae RTS2 (YOR077W) |
Candida albicans | CaO19.3817 | potential zinc finger protein similar to S. cerevisiae RTS2 (YOR077W) |
Caenorhabditis elegans | CELE_Y52B11A.9 | Protein Y52B11A.9 |
Cryptosporidium hominis | Chro.70318 | hypothetical protein |
Cryptosporidium parvum | cgd7_2810 | ortholog of kin17 (RNA metabolism proteins): a family of highly conserved zinc binding C-rich proteins with KOW domains |
Dictyostelium discoideum | DDB_G0269816 | kin17-like protein |
Drosophila melanogaster | Dmel_CG5649 | CG5649 gene product from transcript CG5649-RA |
Echinococcus granulosus | EgrG_001198600 | zinc finger protein rts2 |
Entamoeba histolytica | EHI_038660 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_001198600 | zinc finger protein rts2 |
Homo sapiens | ENSG00000151657 | Kin17 DNA and RNA binding protein |
Loa Loa (eye worm) | LOAG_08415 | KIN protein |
Mus musculus | ENSMUSG00000037262 | antigenic determinant of rec-A protein |
Neospora caninum | NCLIV_013960 | hypothetical protein, conserved |
Oryza sativa | 4333286 | Os03g0570300 |
Plasmodium berghei | PBANKA_1330800 | DNA/RNA-binding protein KIN17, putative |
Plasmodium falciparum | PF3D7_1467500 | DNA/RNA-binding protein KIN17, putative |
Plasmodium knowlesi | PKNH_1213800 | DNA/RNA-binding protein KIN17, putative |
Plasmodium yoelii | PY05576 | Drosophila melanogaster KIN17 protein |
Saccharomyces cerevisiae | YOR077W | Rts2p |
Schistosoma japonicum | Sjp_0302290 | KIN, antigenic determinant of recA protein homolog, putative |
Schistosoma mansoni | Smp_023250.1 | hypothetical protein |
Schistosoma mansoni | Smp_023250.2 | hypothetical protein |
Schmidtea mediterranea | mk4.000983.05 | |
Toxoplasma gondii | TGME49_286690 | DNA/RNA-binding protein KIN17 domain-containing protein |
Theileria parva | TP01_0107 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_292740 | spbc365.09C protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y52B11A.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y52B11A.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y52B11A.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y52B11A.9 | Caenorhabditis elegans | sterile | wormbase |
YOR077W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_286690 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.