Detailed view for PF3D7_1468100

Basic information

TDR Targets ID: 2979
Plasmodium falciparum, conserved Plasmodium protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.9918 | Length (AA): 2558 | MW (Da): 295830 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13418   Galactose oxidase, central domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 17 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
729 1055 1zgk (A) 324 609 12.00 0 0.67 -0.16 -0.1
131 344 4r58 (A) 12 218 25.00 0.24 1 0.335959 -0.26
159 480 4o87 (A) 4 275 31.00 0.016 0.47 0.13618 0.63
802 926 5a10 (A) 8 132 29.00 0.0035 0.69 0.268166 0.46
809 1042 3ii7 (A) 320 513 20.00 0.088 1 0.0886777 0.48
1387 1733 2fds (A) 2 306 25.00 0.82 0.87 0.229953 0.19
1757 1956 2olu (A) 193 361 29.00 0.59 0.19 -0.0375139 0.81
1861 2051 1c1g (A) 29 224 26.00 0.39 0.06 0.292968 -0.86
2348 2555 4tql (A) 9 221 7.00 0.066 0 0.273114 -1.75
63 290 4r58 (A) 6 218 21.00 0.29 0.99 0.234502 -0.09
159 481 4o87 (A) 4 275 31.00 0.032 0.26 0.0885693 0.91
740 1032 4asc (A) 333 593 17.00 0.033 0.88 0.0689322 1.21
786 1037 3ii7 (A) 302 513 18.00 0.034 0.84 0.0638916 0.66
797 921 5a10 (A) 8 132 29.00 0.0031 0.48 0.245105 0.49
1381 1727 2fds (A) 2 306 25.00 0.31 0.79 0.216959 0.25
1747 1946 2olu (A) 193 361 29.00 0.62 0.19 -0.0365527 0.81
2034 2213 4f61 (I) 36 231 22.00 0.77 0.01 0.432623 -2.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, Female Gametocyte. Otto TD PlasmoDB Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_141603)

Species Accession Gene Product
Babesia bovis BBOV_III010280   hypothetical protein
Cryptosporidium hominis Chro.20038   hypothetical protein
Cryptosporidium parvum cgd2_300   kelch repeat-containing proteins that is fused to a HSP90-like ATpase
Neospora caninum NCLIV_043930   Kelch repeat-containing proteins that is fused to a HSP90-like ATpase, related
Plasmodium berghei PBANKA_1331400   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1468100   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1213100   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_117060   hypothetical protein, conserved
Plasmodium yoelii PY01412   ERYTHROCYTE MEMBRANE PROTEIN PFEMP3
Toxoplasma gondii TGME49_305340   corepressor complex CRC230
Theileria parva TP02_0119   hypothetical protein

Essentiality

PF3D7_1468100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1331400 Plasmodium berghei Essential plasmo
TGME49_305340 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1468100 (Plasmodium falciparum), conserved Plasmodium protein, unknown function
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