Detailed view for PF3D7_1469200

Basic information

TDR Targets ID: 2990
Plasmodium falciparum, shewanella-like protein phosphatase 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.0132 | Length (AA): 358 | MW (Da): 42326 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 358 1s95 (A) 180 496 15.00 0 1 1.07 -0.69
35 318 1v73 (A) 50 323 24.00 0 1 1.18 -1
40 342 1v73 (A) 54 336 24.00 0 1 1.09 -1.05
4 342 4ja7 (A) 183 495 14.00 0.00000064 1 1.06023 0.17
26 303 2z72 (A) 46 313 24.00 0.095 1 1.08284 -0.17
57 299 2z72 (A) 72 309 27.00 0 1 1.03077 -0.39
250 310 4rsi (A) 454 518 39.00 0.9 0.05 0.377391 0.81
303 333 2eoj (A) 6 36 16.00 0.32 0.04 0.279892 -0.4
4 333 3h63 (A) 183 486 13.00 0.00000013 1 1.01879 0.26
26 338 2z72 (A) 46 338 24.00 0.0007 1 1.1593 -0.25
54 136 4j6o (A) 172 265 33.00 0.63 0.48 0.262444 0.81
57 299 2z72 (A) 72 309 27.00 0 1 1.03037 -0.38
303 337 2emk (A) 6 40 20.00 0.2 0.03 0.335765 -0.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early schizont, late schizont, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile late trophozoite, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, early ring, early trophozoite, late ring, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Male Gametocyte. Otto TD Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_130954)

Species Accession Gene Product
Arabidopsis thaliana AT1G07010   shewenella-like protein phosphatase 1
Arabidopsis thaliana AT1G18480   shewenella-like protein phosphatase 2
Cryptosporidium hominis Chro.80040   hypothetical protein
Cryptosporidium parvum cgd8_290   serine-threonine protein phosphatase
Leishmania braziliensis LbrM.29.0380   hypothetical protein, conserved
Leishmania braziliensis LbrM.22.1390   Serine-threonin protein phosphatase, putative
Leishmania donovani LdBPK_290450.1   hypothetical protein, conserved
Leishmania donovani LdBPK_221340.1   Serine-threonin protein phosphatase, putative
Leishmania infantum LinJ.29.0450   hypothetical protein, conserved
Leishmania infantum LinJ.22.1340   Serine-threonin protein phosphatase, putative
Leishmania major LmjF.29.0440   hypothetical protein, conserved
Leishmania major LmjF.22.1490   Serine-threonin protein phosphatase, putative
Leishmania mexicana LmxM.22.1490   Serine-threonin protein phosphatase, putative
Leishmania mexicana LmxM.08_29.0440   hypothetical protein, conserved
Neospora caninum NCLIV_009030   Metallophosphoesterase, related
Oryza sativa 4348542   Os10g0394100
Oryza sativa 4350234   Os11g0261900
Plasmodium berghei PBANKA_1332400   shewanella-like protein phosphatase 1
Plasmodium falciparum PF3D7_1469200   shewanella-like protein phosphatase 1, putative
Plasmodium knowlesi PKNH_1211800   shewanella-like protein phosphatase 1, putative
Plasmodium vivax PVX_117005   shewanella-like protein phosphatase 1, putative
Plasmodium yoelii PY03645   Ser/Thr protein phosphatase, putative
Trypanosoma brucei gambiense Tbg972.6.460   serine/threonine protein phosphatase, putative
Trypanosoma brucei Tb927.6.750   kinetoplastid-specific phospho-protein phosphatase, putative
Trypanosoma cruzi TcCLB.511825.170   serine/threonine protein phosphatase, putative
Trypanosoma cruzi TcCLB.508409.329   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508075.14   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508323.190   serine/threonine protein phosphatase, putative
Toxoplasma gondii TGME49_254770   Ser/Thr phosphatase family protein

Essentiality

PF3D7_1469200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.750 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.750 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.750 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.750 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_254770 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1469200 (Plasmodium falciparum), shewanella-like protein phosphatase 1, putative
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