Detailed view for LmjF.03.0010

Basic information

TDR Targets ID: 29914
Leishmania major, hypothetical protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.9611 | Length (AA): 1003 | MW (Da): 107495 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 20 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
89 340 1o6v (A) 160 417 15.00 0.00000000002 0.96 0.43 0.01
156 318 1h6t (A) 61 220 19.00 0.000000043 1 0.45 -0.19
198 326 1d0b (A) 103 228 30.00 0.00000059 1 0.6 -1.06
272 595 1o6v (A) 131 419 28.00 0 1 0.61 -0.42
582 848 1jl5 (A) 1072 1331 27.00 0.00000041 1 0.54 -0.5
890 1003 1jl5 (A) 1140 1245 23.00 0.00000065 0.89 0.41 -0.54
43 109 3lrq (A) 8 76 24.00 0 0.85 0.3583 -0.72
45 90 2fui (A) 5 61 24.00 0 0.99 0.115362 0.16
48 87 5dka (A) 35 77 35.00 0 0.64 0.26638 0.44
198 326 4aw4 (A) 125 250 30.00 0.0000068 1 0.597414 -0.95
214 325 1xeu (A) 96 203 31.00 0.02 1 0.540465 -0.55
234 611 4peq (B) 10 429 29.00 0.029 1 0.446669 0.64
340 779 4r6g (A) 6 464 25.00 0.0000088 1 0.552484 0.8
440 748 3tsr (E) 104 456 29.00 0.15 1 0.406876 0.35
627 735 3zyi (A) 147 258 35.00 0.55 1 0.487474 -0.55
637 1001 4r5d (A) 50 427 26.00 0.00000000074 1 0.475708 0.52
657 829 4r58 (A) 47 213 31.00 0.00000021 1 0.624283 -0.78
709 967 4r5c (A) 30 288 24.00 0.000011 1 0.558025 -0.06
953 1001 4fho (A) 146 192 21.00 0.0084 0.86 0.324153 -0.32
953 1002 1dce (A) 467 515 29.00 0.0064 0.95 0.41115 -0.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126657)

Species Accession Gene Product
Arabidopsis thaliana AT1G15740   leucine-rich repeat-containing protein
Brugia malayi Bm1_13125   ras-binding protein SUR-8
Caenorhabditis elegans CELE_AC7.2   Protein SOC-2, isoform B
Dictyostelium discoideum DDB_G0294094   leucine-rich repeat-containing protein
Drosophila melanogaster Dmel_CG5407   CG5407 gene product from transcript CG5407-RA
Echinococcus granulosus EgrG_000143400   leucine rich repeat and death domain containing protein
Echinococcus granulosus EgrG_000729500   leucine rich repeat protein soc 2
Entamoeba histolytica EHI_167290   leucine rich repeat / protein phosphatase 2C domain containing protein
Entamoeba histolytica EHI_024640   leucine-rich repeat containing protein
Entamoeba histolytica EHI_081720   leucine rich repeat / protein phosphatase 2C domain containing protein
Entamoeba histolytica EHI_066620   leucine rich repeat protein, BspA family
Entamoeba histolytica EHI_076850   leucine-rich repeat containing protein
Entamoeba histolytica EHI_050750   leucine rich repeat / protein phosphatase 2C domain containing protein
Entamoeba histolytica EHI_042230   leucine rich repeat / protein phosphatase 2C domain containing protein
Echinococcus multilocularis EmuJ_000141100   leucine rich repeat and death domain containing protein
Echinococcus multilocularis EmuJ_000143400   leucine rich repeat and death domain containing protein
Echinococcus multilocularis EmuJ_000038300   leucine rich repeat protein SHOC 2
Echinococcus multilocularis EmuJ_000729500   leucine rich repeat protein soc 2
Homo sapiens ENSG00000108061   soc-2 suppressor of clear homolog (C. elegans)
Homo sapiens ENSG00000240720   leucine-rich repeats and death domain containing 1
Leishmania braziliensis LbrM.03.0030   hypothetical protein
Leishmania major LmjF.03.0010   hypothetical protein
Loa Loa (eye worm) LOAG_09352   Ras-binding protein SUR-8
Loa Loa (eye worm) LOAG_12528   sur-8-PB
Mus musculus ENSMUSG00000024976   soc-2 (suppressor of clear) homolog (C. elegans)
Mus musculus ENSMUSG00000040367   leucine rich repeats and death domain containing 1
Oryza sativa 4350068   Os11g0213800
Oryza sativa 4346736   Os09g0325700
Oryza sativa 9267951   Os05g0297500
Oryza sativa 4350057   Os11g0211300
Oryza sativa 4329969   Os02g0613200
Oryza sativa 4350060   Os11g0212000
Oryza sativa 4336323   Os04g0503500
Oryza sativa 4325115   Os01g0260500
Oryza sativa 4329870   Os02g0597300
Oryza sativa 4350067   Os11g0213700
Oryza sativa 9267061   Os08g0265300
Schistosoma japonicum Sjp_0111120   Leucine-rich repeat protein SHOC-2, putative
Schistosoma japonicum Sjp_0058620   Leucine-rich repeat and death domain-containing protein LOC401387 homolog, putative
Schistosoma japonicum Sjp_0305880   Leucine-rich repeat protein SHOC-2, putative
Schistosoma mansoni Smp_129120   shoc2
Schistosoma mansoni Smp_108780   hypothetical protein
Schistosoma mansoni Smp_008450   hypothetical protein
Schmidtea mediterranea mk4.000612.04  
Schmidtea mediterranea mk4.007365.00  
Schmidtea mediterranea mk4.003274.00  
Schmidtea mediterranea mk4.000109.02   Leucine-rich repeat protein soc-2
Schmidtea mediterranea mk4.000109.01  
Schmidtea mediterranea mk4.015576.00  
Schmidtea mediterranea mk4.005922.00   Putative shoc2
Schmidtea mediterranea mk4.020734.00  
Schmidtea mediterranea mk4.003196.01  
Schmidtea mediterranea mk4.000550.08  
Trypanosoma brucei gambiense Tbg972.11.1610   T. brucei spp.-specific protein,hypothetical protein, conserved,leucine-rich repeat protein (LRRP),leucine-rich repeat protein (
Trypanosoma brucei gambiense Tbg972.3.1250   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.3.1490   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0448   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0838   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.2.950   paraflagellar rod component, putative
Trypanosoma brucei Tb927.6.130   hypothetical leucine-rich repeat protein 1 (LRRP1)
Trypanosoma brucei Tb927.1.480   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0703   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.1.370   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0602   leucine-rich repeat protein 1 (LRRP1), putative
Trypanosoma brucei Tb927.1.290   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0560   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.11.1510   leucine rich repeat protein, putative
Trypanosoma brucei Tb11.v5.0551   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.2.170   leucine-rich repeat protein 1 (LRRP1), putative
Trichomonas vaginalis TVAG_480940   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_RG_DS113350_7   conserved hypothetical protein
Trichomonas vaginalis TVAG_129560   leucine-rich transmembrane proteins, putative
Trichomonas vaginalis TVAG_148510   protein phosphatase 2C-2, putative
Trichomonas vaginalis TVAG_489945   leucine-rich repeat protein, BspA family
Trichomonas vaginalis TVAG_334930   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_257810   leucine-rich repeat protein, BspA family
Trichomonas vaginalis TVAG_171040   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_093780   leucine-rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_028660   leucine-rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_321810   leucine-rich repeat containing protein, putative
Trichomonas vaginalis TVAG_093970   leucine-rich repeat containing protein, putative
Trichomonas vaginalis TVAG_319030   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_210020   podocan, putative
Trichomonas vaginalis TVAG_416550   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_312980   leucine-rich repeat containing protein, putative
Trichomonas vaginalis TVAG_288800   leucine-rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_168890   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_358120   protein phosphatase 2C, putative

Essentiality

LmjF.03.0010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.1490 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.1490 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.1490 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.1490 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.950 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.950 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.950 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.2.950 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.480 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.480 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.480 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.480 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.290 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.290 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.290 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.290 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.370 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.370 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.370 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.370 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_AC7.2 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.03.0010 (Leishmania major), hypothetical protein
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