Detailed view for TcCLB.511283.170

Basic information

TDR Targets ID: 30007
Trypanosoma cruzi, Utp14 protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.4286 | Length (AA): 1052 | MW (Da): 117574 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04615   Utp14 protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0032040   small subunit processome  
GO:0006364   rRNA processing  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
428 645 2yfa (A) 49 270 4.00 0 0 0.260324 -0.97
450 521 3oa7 (A) 4 462 32.00 0.54 0.08 0.330141 -0.6
468 679 5cwg (A) 5 196 28.00 0.69 0.55 0.366221 -0.46
810 1030 4tql (A) 10 231 8.00 0.0015 0 0.275576 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127996)

Species Accession Gene Product
Arabidopsis thaliana AT4G02400   U3 ribonucleoprotein family protein
Arabidopsis thaliana AT5G08600   U3 ribonucleoprotein (Utp) family protein
Babesia bovis BBOV_IV011120   hypothetical protein
Brugia malayi Bm1_15540   Utp14 protein
Candida albicans CaO19.7552   similar to S. cerevisiae YML093W
Caenorhabditis elegans CELE_F27C1.6   Protein F27C1.6
Cryptosporidium hominis Chro.10229   hypothetical protein
Cryptosporidium parvum cgd1_2000   predicted coiled coil protein
Dictyostelium discoideum DDB_G0279371   U3 small nucleolar ribonucleoprotein
Drosophila melanogaster Dmel_CG12301   CG12301 gene product from transcript CG12301-RA
Echinococcus granulosus EgrG_001175600   U3 small nucleolar RNA associated protein 14
Entamoeba histolytica EHI_138370   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001175600   U3 small nucleolar RNA associated protein 14
Homo sapiens ENSG00000156697   UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
Homo sapiens ENSG00000253797   UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
Leishmania braziliensis LbrM.32.0210   hypothetical protein, conserved
Leishmania donovani LdBPK_320150.1   Utp14 protein, putative
Leishmania infantum LinJ.32.0150   hypothetical protein, conserved
Leishmania major LmjF.32.0150   hypothetical protein, conserved
Leishmania mexicana LmxM.31.0150   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05998   Utp14 protein
Mus musculus ENSMUSG00000063785   UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
Mus musculus ENSMUSG00000079470   UTP14, U3 small nucleolar ribonucleoprotein, homolog B (yeast)
Neospora caninum NCLIV_020190   Os03g0343300 protein, related
Oryza sativa 4332800   Os03g0343300
Onchocerca volvulus OVOC13453  
Plasmodium yoelii PY05632   hypothetical protein
Saccharomyces cerevisiae YML093W   Utp14p
Schistosoma japonicum Sjp_0212960   U3 small nucleolar RNA-associated protein 14 homolog B, putative
Schistosoma mansoni Smp_012340   hypothetical protein
Trypanosoma brucei gambiense Tbg972.10.17410   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.14330   Utp14 protein, putative
Trypanosoma congolense TcIL3000_10_12200   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511283.170   Utp14 protein, putative
Trypanosoma cruzi TcCLB.506527.10   Utp14 protein, putative
Toxoplasma gondii TGME49_205500   hypothetical protein
Theileria parva TP01_0777   hypothetical protein
Theileria parva TP01_0778   hypothetical protein
Trichomonas vaginalis TVAG_283500   U3 small nucleolar RNA-associated protein, putative

Essentiality

TcCLB.511283.170 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14330 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14330 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.14330 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.14330 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F27C1.6 Caenorhabditis elegans larval arrest wormbase
CELE_F27C1.6 Caenorhabditis elegans larval lethal wormbase
CELE_F27C1.6 Caenorhabditis elegans slow growth wormbase
CELE_F27C1.6 Caenorhabditis elegans sterile wormbase
YML093W Saccharomyces cerevisiae inviable yeastgenome
TGME49_205500 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511283.170 (Trypanosoma cruzi), Utp14 protein, putative
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