Detailed view for PF3D7_1470400

Basic information

TDR Targets ID: 3001
Plasmodium falciparum, mitochondrial pyruvate carrier protein 2, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.2972 | Length (AA): 129 | MW (Da): 15255 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03650   Uncharacterised protein family (UPF0041)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0006850   mitochondrial pyruvate transport  
GO:0003674   molecular_function  
GO:0005743   mitochondrial inner membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 40 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, Sporozoite, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127980)

Species Accession Gene Product
Arabidopsis thaliana AT4G05590   hypothetical protein
Arabidopsis thaliana AT4G22310   hypothetical protein
Babesia bovis BBOV_III001040   conserved hypothetical protein
Brugia malayi Bm1_48080   Hypothetical UPF0041 protein F53F10.3 in chromosome I, putative
Candida albicans CaO19.6435   similar to S. cerevisiae FMP43 (YGR243W) mitochondrial protein and to YHR162W
Candida albicans CaO19.13793   similar to S. cerevisiae FMP43 (YGR243W) mitochondrial protein and to YHR162W
Caenorhabditis elegans CELE_F53F10.3   Protein F53F10.3
Dictyostelium discoideum DDB_G0268478   UPF0041 family protein
Drosophila melanogaster Dmel_CG9399   CG9399 gene product from transcript CG9399-RE
Drosophila melanogaster Dmel_CG9396   CG9396 gene product from transcript CG9396-RA
Drosophila melanogaster Dmel_CG32832   CG32832 gene product from transcript CG32832-RB
Echinococcus granulosus EgrG_000090100   brain protein 44
Echinococcus multilocularis EmuJ_000090100   brain protein 44
Homo sapiens ENSG00000143158   mitochondrial pyruvate carrier 2
Leishmania braziliensis LbrM.14.1650   hypothetical protein, conserved
Leishmania donovani LdBPK_141560.1   Mitochondrial pyruvate carrier 2
Leishmania infantum LinJ.14.1560   hypothetical protein, conserved
Leishmania major LmjF.14.1460   hypothetical protein, conserved
Leishmania mexicana LmxM.14.1460   hypothetical protein, conserved
Mus musculus ENSMUSG00000026568   mitochondrial pyruvate carrier 2
Neospora caninum NCLIV_020880   hypothetical protein
Oryza sativa 4343123   Os07g0449100
Oryza sativa 4345333   Os08g0344300
Onchocerca volvulus OVOC1107   Putative mitochondrial pyruvate carrier 1
Onchocerca volvulus OVOC1106   Putative mitochondrial pyruvate carrier 1
Plasmodium berghei PBANKA_1333600   mitochondrial pyruvate carrier protein 2, putative
Plasmodium falciparum PF3D7_1470400   mitochondrial pyruvate carrier protein 2, putative
Plasmodium knowlesi PKNH_1210600   mitochondrial pyruvate carrier protein 2, putative
Plasmodium vivax PVX_116950   mitochondrial pyruvate carrier protein 2, putative
Plasmodium yoelii PY06652   Arabidopsis thaliana At4g22310-related
Saccharomyces cerevisiae YGR243W   Fmp43p
Saccharomyces cerevisiae YHR162W   Mpc2p
Schistosoma japonicum Sjp_0215730   Brain protein 44, putative
Schistosoma mansoni Smp_099420   hypothetical protein
Schmidtea mediterranea mk4.001627.09   Probable mitochondrial pyruvate carrier 1
Schmidtea mediterranea mk4.001149.09  
Trypanosoma brucei gambiense Tbg972.7.3870   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.3520   Mitochondrial pyruvate carrier 2
Trypanosoma congolense TcIL3000_7_2740   Mitochondrial pyruvate carrier 2
Trypanosoma cruzi TcCLB.508265.44   Mitochondrial pyruvate carrier 2
Trypanosoma cruzi TcCLB.506443.40   Mitochondrial pyruvate carrier 2
Toxoplasma gondii TGME49_204370   WD-40 repeat protein
Toxoplasma gondii TGME49_245748   hypothetical protein

Essentiality

PF3D7_1470400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3520 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.3520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.3520 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.3520 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_204370 Toxoplasma gondii Probably non-essential sidik
TGME49_245748 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1470400 (Plasmodium falciparum), mitochondrial pyruvate carrier protein 2, putative
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