Detailed view for PF3D7_1471200

Basic information

TDR Targets ID: 3009
Plasmodium falciparum, inorganic anion exchanger, inorganic anion antiporter
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.4869 | Length (AA): 664 | MW (Da): 75468 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00916   Sulfate permease family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0015116   sulfate transmembrane transporter activity  
GO:0008271   secondary active sulfate transmembrane transporter activity  
GO:0005215   transporter activity  
GO:0008272   sulfate transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
114 314 1rc2 (B) 18 213 12.00 0.000089 0.01 0.38 -0.83
519 627 1vc1 (A) 10 110 8.00 0.00000000054 0.07 0.2 -0.92
76 602 5da0 (A) 15 484 25.00 0.0000000002 1 0.965475 0.35
523 615 4dgf (A) 454 545 15.00 0.27 0.94 0.44086 -0.8
524 602 3lkl (A) 14 91 21.00 0.0065 0.47 0.449776 -0.97
529 638 4dgh (A) 448 550 21.00 0.00015 0.98 0.441463 -0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Ring, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, gametocyte, Oocyst, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129533)

Species Accession Gene Product
Babesia bovis BBOV_II006030   sulfate transporter, putative
Chlamydia trachomatis CT_856   sulfate transporter
Escherichia coli b1206   C4-dicarboxylic acid transporter
Mycobacterium leprae ML2279c   Probable transmembrane transport protein
Mycobacterium tuberculosis Rv1707   Probable conserved transmembrane protein
Mycobacterium tuberculosis Rv3273   Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Mycobacterium ulcerans MUL_5080   transmembrane carbonic anhydrase, SulP
Mycobacterium ulcerans MUL_0666   transmembrane carbonic anhydrase, SulP
Mycobacterium ulcerans MUL_0321   integral membrane transporter
Neospora caninum NCLIV_019650   hypothetical protein
Plasmodium berghei PBANKA_1334400   inorganic anion antiporter, putative
Plasmodium falciparum PF3D7_1471200   inorganic anion exchanger, inorganic anion antiporter
Plasmodium knowlesi PKNH_1209800   sulfate transporter, putative
Plasmodium vivax PVX_116910   sulfate transporter, putative
Plasmodium yoelii PY07224   sulfate permease family protein
Trypanosoma brucei gambiense Tbg972.5.1740   hypothetical protein, conserved
Trypanosoma brucei Tb927.5.1260   Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative
Trypanosoma congolense TcIL3000_5_1250   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_42680   Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative
Trypanosoma cruzi TcCLB.509601.110   Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative
Trypanosoma cruzi TcCLB.509767.110   Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative
Toxoplasma gondii TGME49_280500   inorganic anion transporter, sulfate permease (SulP) family protein
Theileria parva TP02_0554   sulfate transporter, putative

Essentiality

PF3D7_1471200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.1260 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.5.1260 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.1260 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.5.1260 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1206 Escherichia coli non-essential goodall
TGME49_280500 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1471200 (Plasmodium falciparum), inorganic anion exchanger, inorganic anion antiporter
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