Detailed view for PF3D7_1475300

Basic information

TDR Targets ID: 3051
Plasmodium falciparum, cytochrome c oxidase assembly protein COX11, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.7043 | Length (AA): 228 | MW (Da): 26807 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04442   Cytochrome c oxidase assembly protein CtaG/Cox11

Gene Ontology

Mouse over links to read term descriptions.
GO:0005739   mitochondrion  
GO:0005507   copper ion binding  
GO:0008535   respiratory chain complex IV assembly  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
78 205 1so9 (A) 21 150 40.00 0 1 0.98 -0.42
77 205 1so9 (A) 22 150 38.00 0 1 0.845189 0.21
77 205 1so9 (A) 22 150 38.00 0 1 0.856389 0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, sporozoite, early schizont, late ring, late schizont, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile early trophozoite, Sporozoite, Female Gametocyte, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128258)

Species Accession Gene Product
Arabidopsis thaliana AT1G02410   cytochrome c oxidase assembly protein CtaG / Cox11
Babesia bovis BBOV_IV000820   cytochrome c oxidase assembly protein Cox11 subunit
Brugia malayi Bm1_49700   Cytochrome c oxidase assembly protein CtaG / Cox11 containing protein
Candida albicans CaO19.1416   assembly of cytochrome c oxidase
Candida albicans CaO19.8992   assembly of cytochrome c oxidase
Caenorhabditis elegans CELE_JC8.5   Protein JC8.5
Dictyostelium discoideum DDB_G0289353   cytochrome c oxidase assembly protein
Drosophila melanogaster Dmel_CG31648   CG31648 gene product from transcript CG31648-RA
Echinococcus granulosus EgrG_000923400   Cytochrome c oxidase assembly protein COX11
Echinococcus multilocularis EmuJ_000923400   Cytochrome c oxidase assembly protein COX11
Homo sapiens ENSG00000166260   COX11 cytochrome c oxidase copper chaperone
Leishmania braziliensis LbrM.03.0110   cytochrome c oxidase assembly protein, putative
Leishmania donovani LdBPK_030090.1   cytochrome c oxidase assembly protein, putative
Leishmania infantum LinJ.03.0090   cytochrome c oxidase assembly protein, putative
Leishmania major LmjF.03.0100   cytochrome c oxidase assembly protein, putative
Leishmania mexicana LmxM.03.0100   cytochrome c oxidase assembly protein, putative
Loa Loa (eye worm) LOAG_00124   cytochrome c oxidase assembly protein CtaG/Cox11 containing protein
Mus musculus 69802   cytochrome c oxidase assembly protein 11
Neospora caninum NCLIV_022110   cytochrome C oxidase assembly protein cox11, putative
Oryza sativa 4333922   Os03g0718600
Plasmodium berghei PBANKA_1300900   cytochrome c oxidase assembly protein COX11, putative
Plasmodium falciparum PF3D7_1475300   cytochrome c oxidase assembly protein COX11, putative
Plasmodium knowlesi PKNH_1245600   cytochrome c oxidase assembly protein COX11, putative
Plasmodium vivax PVX_118645   cytochrome c oxidase assembly protein COX11, putative
Plasmodium yoelii PY00708   Caenorhabditis elegans JC8.5
Saccharomyces cerevisiae YPL132W   Cox11p
Schistosoma japonicum Sjp_0014940   ko:K02258 cytochrome c oxidase subunit XI assembly protein, putative
Schistosoma mansoni Smp_141470   cytochrome C oxidase assembly protein cox11
Schmidtea mediterranea mk4.024417.00   Cytochrome c oxidase assembly protein COX11, mitochondrial
Schmidtea mediterranea mk4.007375.00   Cytochrome c oxidase assembly protein COX11, mitochondrial
Trypanosoma brucei gambiense Tbg972.10.3950   cytochrome c oxidase assembly protein, putative
Trypanosoma brucei Tb927.10.3120   cytochrome c oxidase assembly protein, putative
Trypanosoma congolense TcIL3000_10_2580   cytochrome c oxidase assembly protein, putative
Trypanosoma cruzi TcCLB.504867.70   cytochrome c oxidase assembly protein, putative
Trypanosoma cruzi TcCLB.510943.130   cytochrome c oxidase assembly protein, putative
Toxoplasma gondii TGME49_202800   cytochrome c oxidase assembly protein COX11 protein, putative
Theileria parva TP01_0104   cytochrome c oxidase assembly protein, putative
Wolbachia endosymbiont of Brugia malayi Wbm0491   cytochrome C oxidase assembly protein

Essentiality

PF3D7_1475300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.3120 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.3120 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.3120 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.3120 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_JC8.5 Caenorhabditis elegans slow growth wormbase
PBANKA_1300900 Plasmodium berghei Essential plasmo
TGME49_202800 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Cytochrome Oxidase (1.9.3.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

39 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1475300 (Plasmodium falciparum), cytochrome c oxidase assembly protein COX11, putative
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