Detailed view for TcCLB.506943.100

Basic information

TDR Targets ID: 30547
Trypanosoma cruzi, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7486 | Length (AA): 703 | MW (Da): 79051 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00515   Tetratricopeptide repeat
PF13181   Tetratricopeptide repeat
PF13414   TPR repeat
PF13432   Tetratricopeptide repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 146 2fo7 (A) 5 129 21.00 0 0.91 0.51 -0.77
22 116 1elr (A) 235 330 14.00 0.000002 0.86 0.48 -1.43
265 382 1na0 (A) 9 125 44.00 0 1 0.87 -1.77
265 554 1w3b (A) 79 398 29.00 0 1 0.69 -0.35
365 450 1na3 (A) 1 86 38.00 0.0000000003 1 0.78 -1.94
398 594 1xnf (A) 58 269 28.00 0.0000000044 1 0.54 -0.47
437 531 1elw (A) 5 99 32.00 0.00000022 1 0.72 -1.82
12 76 2kc7 (A) 35 99 15.00 0.0088 0.03 0.246561 -0.22
95 554 3fp3 (A) 170 616 25.00 0.000000066 1 0.753339 0.7
265 400 2fo7 (A) 1 135 43.00 0 1 0.811457 -0.99
272 361 1fch (A) 458 546 33.00 0.000015 0.99 0.610023 -0.74
435 484 2xgs (B) 90 139 32.00 0 0.78 0.608824 -1.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_131333)

Species Accession Gene Product
Entamoeba histolytica EHI_133920   TPR repeat protein
Giardia lamblia GL50803_16934   Tetratricopeptide repeat protein
Homo sapiens ENSG00000139865   tetratricopeptide repeat domain 6
Leishmania braziliensis LbrM.30.2980   hypothetical protein, conserved
Leishmania donovani LdBPK_303030.1   TPR repeat/Tetratricopeptide repeat, putative
Leishmania infantum LinJ.30.3030   hypothetical protein, conserved
Leishmania major LmjF.30.3010   hypothetical protein, conserved
Leishmania mexicana LmxM.29.3010   hypothetical protein, conserved
Mus musculus 102642336   tetratricopeptide repeat protein 6-like
Schistosoma japonicum Sjp_0095140   Tetratricopeptide repeat protein 6, putative
Schistosoma japonicum Sjp_0106850   IPR001440,Tetratricopeptide TPR_1;IPR013026,Tetratricopeptide region;IPR008940,Protein prenyltransferase,domain-containing
Schistosoma japonicum Sjp_0070880   IPR001440,Tetratricopeptide TPR_1;IPR013105,Tetratricopeptide TPR_2;IPR013026,Tetratricopeptide region,domain-containing
Schistosoma japonicum Sjp_0083820   IPR013026,Tetratricopeptide region;IPR008940,Protein prenyltransferase,domain-containing
Schistosoma mansoni Smp_139860   o-linked n-acetylglucosamine transferase ogt
Schmidtea mediterranea mk4.010833.01  
Schmidtea mediterranea mk4.003237.02  
Trypanosoma cruzi TcCLB.506943.100   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509065.110   hypothetical protein, conserved

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.506943.100 (Trypanosoma cruzi), hypothetical protein, conserved
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