Detailed view for TcCLB.511407.10

Basic information

TDR Targets ID: 30572
Trypanosoma cruzi, nuclear transport factor 2, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.6023 | Length (AA): 124 | MW (Da): 13955 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02136   Nuclear transport factor 2 (NTF2) domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 118 1zo2 (A) 9 125 40.00 0 1 1.64 -2.15
5 123 1jkg (A) 15 140 28.00 0 1 1.28 -1.57
2 118 1zo2 (A) 9 125 40.00 0 1 1.53285 -1.32
2 120 1gy7 (A) 4 123 33.00 0 1 1.48938 -1.11
2 119 1gy6 (A) 6 122 30.00 0 1 1.43541 -1.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127878)

Species Accession Gene Product
Arabidopsis thaliana AT1G27970   nuclear transport factor 2B
Arabidopsis thaliana AT1G27310   nuclear transport factor 2A
Arabidopsis thaliana AT1G11570   nuclear transport factor 2-like protein
Babesia bovis BBOV_III010930   nuclear transport factor domain containing protein
Brugia malayi Bm1_17200   nuclear transport factor 2 (NTF-2)
Caenorhabditis elegans CELE_R05D11.3   Protein RAN-4
Cryptosporidium hominis Chro.40075   nuclear transport factor 2 (NTF-2)
Cryptosporidium parvum cgd4_590   conserved hypothetical protein
Dictyostelium discoideum DDB_G0276425   nuclear transport factor 2
Drosophila melanogaster Dmel_CG10174   Nuclear transport factor-2-related
Drosophila melanogaster Dmel_CG1740   Nuclear transport factor-2
Echinococcus granulosus EgrG_000601000   nuclear transport factor 2
Entamoeba histolytica EHI_182470   nuclear transport factor 2, putative
Echinococcus multilocularis EmuJ_000601000   nuclear transport factor 2
Giardia lamblia GL50803_6724   Protein F17L21.10
Homo sapiens 10204   nuclear transport factor 2
Leishmania braziliensis LbrM.10.0950   nuclear transport factor 2, putative,ntf2-like
Leishmania donovani LdBPK_100900.1   nuclear transport factor 2, putative
Leishmania infantum LinJ.10.0900   nuclear transport factor 2, putative,ntf2-like
Leishmania major LmjF.10.0850   nuclear transport factor 2, putative,ntf2-like
Leishmania mexicana LmxM.10.0850   nuclear transport factor 2, putative,ntf2-like
Loa Loa (eye worm) LOAG_07067   hypothetical protein
Loa Loa (eye worm) LOAG_07068   hypothetical protein
Mus musculus ENSMUSG00000008450   nuclear transport factor 2
Mus musculus 621832   predicted gene 10349
Neospora caninum NCLIV_033140   hypothetical protein
Oryza sativa 4346137   Os08g0532300
Oryza sativa 4325860   Os01g0788200
Onchocerca volvulus OVOC1418  
Plasmodium berghei PBANKA_1030300   nuclear transport factor 2, putative
Plasmodium falciparum PF3D7_1412300   nuclear transport factor 2, putative
Plasmodium knowlesi PKNH_1346000   nuclear transport factor 2, putative
Plasmodium vivax PVX_085840   nuclear transport factor 2, putative
Plasmodium yoelii PY00424   nuclear transport factor 2
Saccharomyces cerevisiae YER009W   Ntf2p
Schistosoma japonicum Sjp_0217920   Nuclear transport factor 2, putative
Schistosoma mansoni Smp_037700   nuclear transport factor
Schmidtea mediterranea mk4.002155.04   Probable nuclear transport factor 2
Schmidtea mediterranea mk4.006583.00   Probable nuclear transport factor 2
Schmidtea mediterranea mk4.002305.00   Probable nuclear transport factor 2
Trypanosoma brucei gambiense Tbg972.8.4020   nuclear transport factor 2, putative
Trypanosoma brucei Tb927.8.4280   nuclear transport factor 2, putative
Trypanosoma congolense TcIL3000_8_4000   nuclear transport factor 2, putative
Trypanosoma cruzi TcCLB.509567.40   nuclear transport factor 2, putative
Trypanosoma cruzi TcCLB.511407.10   nuclear transport factor 2, putative
Toxoplasma gondii TGME49_233350   nuclear transport factor 2, putative
Theileria parva TP02_0050   nuclear transport factor 2, putative
Trichomonas vaginalis TVAG_390880   conserved hypothetical protein
Trichomonas vaginalis TVAG_296260   conserved hypothetical protein

Essentiality

TcCLB.511407.10 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R05D11.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_R05D11.3 Caenorhabditis elegans larval arrest wormbase
CELE_R05D11.3 Caenorhabditis elegans slow growth wormbase
CELE_R05D11.3 Caenorhabditis elegans sterile wormbase
YER009W Saccharomyces cerevisiae inviable yeastgenome
TGME49_233350 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511407.10 (Trypanosoma cruzi), nuclear transport factor 2, putative
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