Detailed view for TcCLB.435519.19

Basic information

TDR Targets ID: 30700
Trypanosoma cruzi, Centrosomal protein of 164 kDa, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.4453 | Length (AA): 203 | MW (Da): 22051 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00397   WW domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
77 107 1wr7 (A) 9 39 23.00 0.00000000042 0.81 0.63 -1.75
81 106 1o6w (A) 4 29 38.00 0.000055 0.87 0.71 -1.2
55 106 4rex (A) 163 202 35.00 0.32 0.2 0.305358 0.12
56 106 2m8i (A) 1 41 34.00 0 0.44 0.308532 0.11
75 107 1ymz (A) 1 34 42.00 0.000067 0.72 0.722662 -0.81
75 106 2dmv (A) 6 37 25.00 0 0.55 0.556935 -1.1
76 106 5aht (A) 7 37 26.00 0 0.36 0.564009 -1.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131535)

Species Accession Gene Product
Giardia lamblia GL50803_24423   Hypothetical protein
Leishmania braziliensis LbrM.28.2590   hypothetical protein, conserved
Leishmania braziliensis LbrM.12.0530   hypothetical protein, conserved
Leishmania donovani LdBPK_120470.1   WW domain containing protein, putative
Leishmania donovani LdBPK_282560.1   WW domain containing protein, putative
Leishmania infantum LinJ.28.2560   hypothetical protein, conserved
Leishmania infantum LinJ.12.0470   hypothetical protein, conserved
Leishmania major LmjF.12.0510   hypothetical protein, conserved
Leishmania major LmjF.28.2390   hypothetical protein, conserved
Leishmania mexicana LmxM.12.0510   hypothetical protein, conserved
Leishmania mexicana LmxM.28.2390   hypothetical protein, conserved
Schistosoma mansoni Smp_135920   hypothetical protein
Trypanosoma brucei gambiense Tbg972.11.13070   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.1.2250  
Trypanosoma brucei Tb927.11.11650   Centrosomal protein of 164 kDa, putative
Trypanosoma brucei Tb927.1.3560   Centrosomal protein of 164 kDa, putative
Trypanosoma congolense TcIL3000.11.12260   WW domain containing protein, putative
Trypanosoma congolense TcIL3000_0_24030   WW domain containing protein, putative
Trypanosoma cruzi TcCLB.510889.270   Centrosomal protein of 164 kDa, putative
Trypanosoma cruzi TcCLB.506935.10   Centrosomal protein of 164 kDa, putative
Trypanosoma cruzi TcCLB.507527.20   Centrosomal protein of 164 kDa, putative
Trypanosoma cruzi TcCLB.435519.19   Centrosomal protein of 164 kDa, putative
Trypanosoma cruzi TcCLB.506529.590   Centrosomal protein of 164 kDa, putative
Trichomonas vaginalis TVAG_172550   paramyosin, putative
Trichomonas vaginalis TVAG_260210   synaptonemal complex protein, putative
Trichomonas vaginalis TVAG_140540   conserved hypothetical protein
Trichomonas vaginalis TVAG_359680   centrosomal protein of 135 kDa, putative
Trichomonas vaginalis TVAG_312820   conserved hypothetical protein

Essentiality

TcCLB.435519.19 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.3520 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.3520 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.01.3520 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.3560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.3560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.3560 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.1.3560 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.435519.19 (Trypanosoma cruzi), Centrosomal protein of 164 kDa, putative
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