pI: 6.9688 |
Length (AA): 270 |
MW (Da): 29044 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 257 | 2b9m (Y) | 123 | 362 | 30.00 | 0 | 1 | 0.92 | 2.03 |
3 | 258 | 1rq0 (A) | 97 | 333 | 39.00 | 0 | 1 | 1.23 | 0.49 |
3 | 258 | 1rq0 (A) | 97 | 333 | 39.00 | 0 | 1 | 1.25455 | 0.21 |
107 | 191 | 2jva (A) | 1 | 107 | 25.00 | 0 | 0.86 | 0.344715 | -0.17 |
108 | 194 | 2jy9 (A) | 1 | 112 | 22.00 | 0.0097 | 0.5 | 0.285622 | 0.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126947)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G47020 | peptide chain release factor 1 |
Arabidopsis thaliana | AT3G62910 | protein CHLOROPLAST RIBOSOME RELEASE FACTOR 1 |
Babesia bovis | BBOV_IV006160 | peptide chain release factor 1, putative |
Brugia malayi | Bm1_54480 | Peptidyl-tRNA hydrolase domain containing protein |
Candida albicans | CaO19.1303 | Mitochondrial peptide chain release factor |
Candida albicans | CaO19.8883 | Mitochondrial peptide chain release factor |
Caenorhabditis elegans | CELE_W03F8.3 | Protein W03F8.3 |
Chlamydia trachomatis | CT_023 | peptide chain release factor |
Dictyostelium discoideum | DDB_G0283175 | class I peptide chain release factor |
Drosophila melanogaster | Dmel_CG5705 | CG5705 gene product from transcript CG5705-RA |
Escherichia coli | b1211 | peptide chain release factor RF-1 |
Echinococcus granulosus | EgrG_000572700 | peptide chain release factor 1 |
Echinococcus multilocularis | EmuJ_000572700 | peptide chain release factor 1 |
Echinococcus multilocularis | EmuJ_001188000 | inner nuclear membrane protein man1 |
Homo sapiens | ENSG00000112031 | mitochondrial translational release factor 1-like |
Homo sapiens | ENSG00000120662 | mitochondrial translational release factor 1 |
Leishmania braziliensis | LbrM.25.1310 | peptide chain release factor-like protein |
Leishmania donovani | LdBPK_251510.1 | Peptide chain release factor 1, mitochondrial, putative |
Leishmania infantum | LinJ.25.1510 | peptide chain release factor-like protein |
Leishmania major | LmjF.25.1450 | peptide chain release factor-like protein |
Leishmania mexicana | LmxM.25.1450 | peptide chain release factor-like protein |
Loa Loa (eye worm) | LOAG_08061 | peptidyl-tRNA hydrolase domain-containing protein |
Mycobacterium leprae | ML1134 | PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA (RF-1) |
Mus musculus | ENSMUSG00000019774 | mitochondrial translational release factor 1-like |
Mus musculus | ENSMUSG00000022022 | mitochondrial translational release factor 1 |
Mycobacterium tuberculosis | Rv1299 | Probable peptide chain release factor 1 PrfA (RF-1) |
Mycobacterium ulcerans | MUL_3965 | peptide chain release factor 1 |
Neospora caninum | NCLIV_057350 | hypothetical protein |
Neospora caninum | NCLIV_002600 | peptide chain release factor 1, putative |
Oryza sativa | 4338281 | Os05g0277300 |
Oryza sativa | 4351050 | Os11g0657100 |
Onchocerca volvulus | OVOC4071 | Putative peptide chain release factor 1, mitochondrial |
Plasmodium berghei | PBANKA_1016100 | peptide chain release factor 1, putative |
Plasmodium berghei | PBANKA_0833200 | peptide chain release factor 1, putative |
Plasmodium falciparum | PF3D7_1428600 | peptide chain release factor 1 |
Plasmodium falciparum | PF3D7_0932400 | peptide chain release factor 1 |
Plasmodium knowlesi | PKNH_1330100 | peptide chain release factor 1, putative |
Plasmodium knowlesi | PKNH_0731100 | peptide chain release factor 1, putative |
Plasmodium vivax | PVX_085115 | peptide chain release factor 1, putative |
Plasmodium vivax | PVX_087085 | peptide release factor, putative |
Plasmodium yoelii | PY03620 | peptide chain release factor 1 |
Saccharomyces cerevisiae | YGL143C | Mrf1p |
Schistosoma japonicum | Sjp_0213450 | Inner nuclear membrane protein Man1, putative |
Schistosoma japonicum | Sjp_0213460 | ko:K02835 peptide chain release factor RF-1, putative |
Schistosoma mansoni | Smp_047560 | peptide chain release factor |
Schmidtea mediterranea | mk4.000067.08 | |
Schmidtea mediterranea | mk4.002527.03 | Probable peptide chain release factor 1, mitochondrial |
Schmidtea mediterranea | mk4.002527.02 | |
Schmidtea mediterranea | mk4.003200.08 | |
Trypanosoma brucei gambiense | Tbg972.3.780 | peptide chain release factor 1, putative |
Trypanosoma brucei | Tb927.3.1070 | Peptide chain release factor 1, mitochondrial, putative |
Trypanosoma congolense | TcIL3000_0_51810 | Peptide chain release factor 1 like, mitochondrial, putative |
Trypanosoma congolense | TcIL3000_3_290 | Peptide chain release factor 1, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.509455.120 | Peptide chain release factor 1, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.439125.10 | Peptide chain release factor 1, mitochondrial, putative |
Toxoplasma gondii | TGME49_314270 | peptidyl-tRNA hydrolase domain-containing protein |
Toxoplasma gondii | TGME49_207630 | peptidyl-tRNA hydrolase domain-containing protein |
Treponema pallidum | TP0051 | peptide chain release factor 1 |
Theileria parva | TP01_0422 | peptide chain release factor 1, putative |
Theileria parva | TP03_0303 | hypothetical protein |
Theileria parva | TP03_0302 | peptide chain release factor 1, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0358 | peptide chain release factor 1 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1321 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.3.1070 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.1070 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.1070 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.1070 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1211 | Escherichia coli | essential | goodall |
PBANKA_1016100 | Plasmodium berghei | Dispensable | plasmo |
TGME49_314270 | Toxoplasma gondii | Probably essential | sidik |
TGME49_207630 | Toxoplasma gondii | Probably essential | sidik |
TGME49_314270 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_207630 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.