pI: 5.8594 |
Length (AA): 90 |
MW (Da): 10724 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 88 | 1hbk (A) | 1 | 88 | 99.99 | 0 | 1 | 2.24 | -2.38 |
1 | 89 | 2cop (A) | 8 | 94 | 32.00 | 0 | 1 | 1.46 | -1.45 |
1 | 88 | 1hbk (A) | 1 | 88 | 99.99 | 0 | 1 | 2.30028 | -2.33 |
23 | 82 | 2cb8 (A) | 22 | 81 | 33.00 | 0.00000053 | 0.76 | 1.19717 | -1.35 |
1 | 88 | 1hbk (A) | 1 | 88 | 75.00 | 0 | 1 | 2.03678 | -2.22 |
22 | 82 | 2cb8 (A) | 20 | 81 | 36.00 | 0.00000053 | 0.9 | 1.21878 | -1.14 |
1 | 88 | 1hbk (A) | 1 | 88 | 75.00 | 0 | 1 | 2.03178 | -2.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | intra-erythrocytic - 32 hs, Oocyst, Female Gametocyte. | Otto TD Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | merozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 48 hs, late schizont. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | sporozoite, early ring, Ring, Sporozoite. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, Male Gametocyte. | Otto TD Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 24 hs. | Otto TD |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127366)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G31812 | acyl-CoA-binding protein 6 |
Babesia bovis | BBOV_IV000490 | acyl CoA binding protein |
Brugia malayi | Bm1_41480 | Acyl-CoA-binding protein |
Caenorhabditis elegans | CELE_F47B10.7 | Protein ACBP-3 |
Caenorhabditis elegans | CELE_C44E4.6 | Protein ACBP-1 |
Dictyostelium discoideum | DDB_G0270658 | acyl-CoA binding protein |
Drosophila melanogaster | Dmel_CG15829 | CG15829 gene product from transcript CG15829-RB |
Drosophila melanogaster | Dmel_CG8628 | CG8628 gene product from transcript CG8628-RA |
Drosophila melanogaster | Dmel_CG5804 | CG5804 gene product from transcript CG5804-RA |
Drosophila melanogaster | Dmel_CG8498 | CG8498 gene product from transcript CG8498-RB |
Drosophila melanogaster | Dmel_CG8629 | CG8629 gene product from transcript CG8629-RA |
Drosophila melanogaster | Dmel_CG8627 | Diazepam-binding inhibitor |
Echinococcus granulosus | EgrG_000798700 | acyl coenzyme A binding protein |
Echinococcus multilocularis | EmuJ_000798700 | acyl coenzyme A binding protein |
Homo sapiens | 414149 | acyl-CoA binding domain containing 7 |
Homo sapiens | ENSG00000155368 | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) |
Leishmania braziliensis | LbrM.09.0830 | acyl-CoA binding protein, putative |
Leishmania donovani | LdBPK_090800.1 | acyl-CoA binding protein, putative |
Leishmania infantum | LinJ.09.0800 | acyl-CoA binding protein, putative |
Leishmania major | LmjF.09.0750 | acyl-CoA binding protein, putative |
Leishmania mexicana | LmxM.09.0750 | acyl-CoA binding protein, putative |
Mus musculus | ENSMUSG00000026644 | acyl-Coenzyme A binding domain containing 7 |
Mus musculus | ENSMUSG00000026385 | diazepam binding inhibitor |
Mus musculus | ENSMUSG00000038057 | diazepam binding inhibitor-like 5 |
Oryza sativa | 4333305 | Os03g0576600 |
Oryza sativa | 4344735 | Os08g0162800 |
Oryza sativa | 4339921 | Os06g0115300 |
Plasmodium berghei | PBANKA_1427500 | acyl-CoA binding protein, putative |
Plasmodium falciparum | PF3D7_1477800 | acyl-CoA binding protein |
Plasmodium falciparum | PF3D7_0810000 | acyl-CoA binding protein, putative |
Plasmodium falciparum | PF3D7_1001200 | acyl-CoA binding protein, isoform 2, ACBP2 |
Plasmodium knowlesi | PKNH_1430700 | acyl-CoA binding protein, putative |
Plasmodium vivax | PVX_123275 | acyl-CoA binding protein, putative |
Plasmodium yoelii | PY01656 | Acyl CoA binding protein, putative |
Saccharomyces cerevisiae | YGR037C | long-chain fatty acid transporter ACB1 |
Schistosoma japonicum | Sjp_0116460 | ko:K08762 diazepam-binding inhibitor (GABA receptor modulator,, putative |
Schistosoma mansoni | Smp_149150 | acyl-CoA-binding protein (acbp) (diazepam binding inhibitor) (dbi) (endozepine) |
Schmidtea mediterranea | mk4.053068.02 | Acyl-CoA-binding protein homolog 1 |
Schmidtea mediterranea | mk4.001599.03 | Acyl-CoA-binding protein homolog 1 |
Trypanosoma brucei gambiense | Tbg972.11.14300 | acyl-CoA binding protein, putative |
Trypanosoma brucei | Tb927.11.12830 | acyl-CoA binding protein, putative |
Trypanosoma congolense | TcIL3000_0_35820 | acyl-CoA binding protein, putative |
Trypanosoma congolense | TcIL3000_0_22390 | hypothetical protein |
Trypanosoma cruzi | TcCLB.506621.60 | acyl-CoA binding protein, putative |
Trypanosoma cruzi | TcCLB.511555.90 | acyl-CoA binding protein, putative |
Toxoplasma gondii | TGME49_251550 | acyl-coa-binding protein |
Theileria parva | TP01_0067 | acyl CoA binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.52.0001 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.52.0001 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.52.0001 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.52.0001 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1427500 | Plasmodium berghei | Dispensable | plasmo |
TGME49_251550 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.