Detailed view for TcCLB.511303.110

Basic information

TDR Targets ID: 31040
Trypanosoma cruzi, TPR repeat, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.7165 | Length (AA): 876 | MW (Da): 100508 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
396 647 1fch (A) 285 574 19.00 0.0000000000063 1 0.56 -0.57
495 591 1na0 (A) 8 104 25.00 0.000011 0.94 0.63 -1.85
204 314 4s3l (A) 136 249 28.00 0.6 0.02 0.105212 1.95
421 725 4i1a (B) 14 363 15.00 0 1 0.411274 0.3
532 605 3cv0 (A) 351 424 20.00 0 1 0.479575 -1.22
532 609 1fch (A) 300 377 14.00 0 0.51 0.380141 -1.27
711 835 2fo7 (A) 4 131 10.00 0.000031 0.03 0.222994 -0.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_128247)

Species Accession Gene Product
Arabidopsis thaliana AT5G37130   tetratricopeptide repeat domain-containing protein
Arabidopsis thaliana AT5G17270   tetratricopeptide repeat-containing protein
Babesia bovis BBOV_IV006090   tetratricopeptide repeat containing domain protein
Brugia malayi Bm1_46435   Transcription initiation factor TFIID subunit A family protein
Candida albicans CaO19.12816   similar to S. cerevisiae YNL313C
Candida albicans CaO19.5356   similar to S. cerevisiae YNL313C
Caenorhabditis elegans CELE_T20B12.1   Protein T20B12.1
Cryptosporidium hominis Chro.20342   hypothetical protein
Cryptosporidium parvum cgd2_3250   3x TPR domain-containing protein
Dictyostelium discoideum DDB_G0293372   tetratricopeptide repeat domain 27
Drosophila melanogaster Dmel_CG5290   CG5290 gene product from transcript CG5290-RA
Echinococcus granulosus EgrG_000240000   tetratricopeptide repeat protein 27
Entamoeba histolytica EHI_122710   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000240000   tetratricopeptide repeat protein 27
Homo sapiens ENSG00000018699   tetratricopeptide repeat domain 27
Leishmania braziliensis LbrM.17.1400   hypothetical protein, conserved
Leishmania donovani LdBPK_171340.1   hypothetical protein, conserved
Leishmania infantum LinJ.17.1340   hypothetical protein, conserved
Leishmania major LmjF.17.1240   hypothetical protein, conserved
Leishmania mexicana LmxM.17.1240   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_01905   hypothetical protein
Mus musculus ENSMUSG00000024078   tetratricopeptide repeat domain 27
Neospora caninum NCLIV_041560   hypothetical protein
Oryza sativa 4343142   Os07g0455100
Onchocerca volvulus OVOC8858   Tetratricopeptide repeat protein 27 homolog
Plasmodium berghei PBANKA_1409300   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1310800   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1411200   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_122370   hypothetical protein, conserved
Plasmodium yoelii PY02799   unnamed protein product
Saccharomyces cerevisiae YNL313C   Emw1p
Schistosoma japonicum Sjp_0121070   Tetratricopeptide repeat protein 27, putative
Schistosoma mansoni Smp_152860   hypothetical protein
Schmidtea mediterranea mk4.001454.04  
Trypanosoma brucei gambiense Tbg972.5.3560   hypothetical protein, conserved
Trypanosoma brucei Tb927.5.2520   TPR repeat, putative
Trypanosoma congolense TcIL3000_5_2410   Tetratricopeptide repeat/TPR repeat, putative
Trypanosoma cruzi TcCLB.509177.10   TPR repeat, putative
Trypanosoma cruzi TcCLB.511303.110   TPR repeat, putative
Trypanosoma cruzi TcCLB.509175.18   TPR repeat, putative
Toxoplasma gondii TGME49_289190   tetratricopeptide repeat-containing protein
Theileria parva TP01_0417   hypothetical protein, conserved
Theileria parva TP01_0415   hypothetical protein
Trichomonas vaginalis TVAG_208660   TPR repeat-containing protein T20B12.1, putative

Essentiality

TcCLB.511303.110 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.2520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.2520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.5.2520 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.5.2520 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T20B12.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T20B12.1 Caenorhabditis elegans larval arrest wormbase
CELE_T20B12.1 Caenorhabditis elegans slow growth wormbase
CELE_T20B12.1 Caenorhabditis elegans sterile wormbase
YNL313C Saccharomyces cerevisiae inviable yeastgenome
TGME49_289190 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.511303.110 (Trypanosoma cruzi), TPR repeat, putative
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