Detailed view for TcCLB.504181.30

Basic information

TDR Targets ID: 31137
Trypanosoma cruzi, 40S ribosomal protein S23, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.3034 | Length (AA): 143 | MW (Da): 15926 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00164   Ribosomal protein S12/S23

Gene Ontology

Mouse over links to read term descriptions.
GO:0015935   small ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 142 4kzy (X) 1 142 75.00 0 1 1.81791 0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 5OPT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_127029)

Species Accession Gene Product
Arabidopsis thaliana AT5G02960   40S ribosomal protein S23-2
Arabidopsis thaliana AT3G09680   40S ribosomal protein S23-1
Babesia bovis BBOV_III000970   40S ribosomal protein S12P, putative
Brugia malayi Bm1_46875   40S ribosomal protein S23
Candida albicans CaO19.13632   likely cytosolic ribosomal protein similar to S. cerevisiae RPS23A (YGR118W) and RPS23B (YPR132W) small subunit protein S23
Caenorhabditis elegans CELE_F28D1.7   Protein RPS-23
Cryptosporidium parvum cgd6_1390   ribosomal protein S23
Dictyostelium discoideum DDB_G0272250   40S ribosomal protein S23
Drosophila melanogaster Dmel_CG8415   Ribosomal protein S23
Echinococcus granulosus EgrG_000694380   ribosomal protein S23 putative
Entamoeba histolytica EHI_108500   40S ribosomal protein S23, putative
Entamoeba histolytica EHI_040830   40S ribosomal protein S23, putative
Entamoeba histolytica EHI_020310   40S ribosomal protein S23, putative
Entamoeba histolytica EHI_081320   40S ribosomal protein S23, putative
Echinococcus multilocularis EmuJ_000694380   ribosomal protein S23, putative
Giardia lamblia GL50803_14699   Ribosomal protein S23
Homo sapiens ENSG00000186468   ribosomal protein S23
Leishmania braziliensis LbrM.21.1290   40S ribosomal protein S23, putative
Leishmania braziliensis LbrM.21.1300   40S ribosomal protein S23, putative
Leishmania donovani LdBPK_211300.1   40S ribosomal protein S23, putative
Leishmania infantum LinJ.21.1300   40S ribosomal protein S23, putative
Leishmania infantum LinJ.21.1310   40S ribosomal protein S23, putative
Leishmania major LmjF.21.1070   40S ribosomal protein S23, putative
Leishmania major LmjF.21.1060   40S ribosomal protein S23, putative
Leishmania mexicana LmxM.21.1070   40S ribosomal protein S23, putative
Leishmania mexicana LmxM.21.1060   40S ribosomal protein S23, putative
Loa Loa (eye worm) LOAG_01592   ribosomal protein S23
Loa Loa (eye worm) LOAG_09808   ribosomal protein S23
Mus musculus 66475   ribosomal protein S23
Mus musculus 668809   predicted gene 9372
Neospora caninum NCLIV_030490   30S ribosomal protein S12, related
Oryza sativa 4327414   Os01g0834500
Oryza sativa 4334580   Os03g0818400
Oryza sativa 9266509   Os01g0834601
Onchocerca volvulus OVOC9885   40S ribosomal protein S23 homolog
Onchocerca volvulus OVOC6803   40S ribosomal protein S23 homolog
Plasmodium berghei PBANKA_0405300   40S ribosomal protein S23, putative
Plasmodium falciparum PF3D7_0306900   40S ribosomal protein S23, putative
Plasmodium knowlesi PKNH_0835700   40S ribosomal protein S23, putative
Plasmodium vivax PVX_119470   40S ribosomal protein S23, putative
Plasmodium yoelii PY05754   ribosomal protein S23
Saccharomyces cerevisiae YGR118W   ribosomal 40S subunit protein S23A
Saccharomyces cerevisiae YPR132W   ribosomal 40S subunit protein S23B
Schistosoma japonicum Sjp_0077480   ko:K02973 small subunit ribosomal protein S23e, putative
Schistosoma mansoni Smp_074470   30S ribosomal protein S12
Schmidtea mediterranea mk4.002346.02   40S ribosomal protein S23
Trypanosoma brucei gambiense Tbg972.10.1310   hypothetical protein, unlikely
Trypanosoma brucei gambiense Tbg972.10.1320   hypothetical protein, unlikely
Trypanosoma brucei Tb927.10.1090   40S ribosomal protein S23, putative
Trypanosoma brucei Tb927.10.1080   40S ribosomal protein S23, putative
Trypanosoma congolense TcIL3000_10_890   40S ribosomal protein S23, putative
Trypanosoma cruzi TcCLB.504181.20   40S ribosomal protein S23, putative
Trypanosoma cruzi TcCLB.509695.180   40S ribosomal protein S23, putative
Trypanosoma cruzi TcCLB.504181.30   40S ribosomal protein S23, putative
Trypanosoma cruzi TcCLB.509695.184   40S ribosomal protein S23, putative
Toxoplasma gondii TGME49_229670   ribosomal protein RPS23
Theileria parva TP03_0745   40S ribosomal protein S23, putative
Theileria parva TP05_0017   ribosomal protein S12, putative
Trichomonas vaginalis TVAG_249090   40S ribosomal protein S23, putative
Trichomonas vaginalis TVAG_109530   40S ribosomal protein S23, putative
Trichomonas vaginalis TVAG_305300   40S ribosomal protein S23, putative
Trichomonas vaginalis TVAG_109730   40S ribosomal protein S23, putative
Trichomonas vaginalis TVAG_159830   40S ribosomal protein S23, putative
Trichomonas vaginalis TVAG_198620   40S ribosomal protein S23, putative
Trichomonas vaginalis TVAG_071920   40S ribosomal protein S23, putative
Trichomonas vaginalis TVAG_430260   40S ribosomal protein S23, putative

Essentiality

TcCLB.504181.30 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1080 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1080 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.1080 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1080 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F28D1.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_F28D1.7 Caenorhabditis elegans larval arrest wormbase
CELE_F28D1.7 Caenorhabditis elegans sterile wormbase
PBANKA_0405300 Plasmodium berghei Essential plasmo
TGME49_229670 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TcCLB.504181.30 (Trypanosoma cruzi), 40S ribosomal protein S23, putative
Title for this comment
Comment