Detailed view for TcCLB.509137.30

Basic information

TDR Targets ID: 31406
Trypanosoma cruzi, imidazolonepropionase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.0787 | Length (AA): 430 | MW (Da): 46733 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01979   Amidohydrolase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016812   hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides  
GO:0016810   hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds  
GO:0005737   cytoplasm  
GO:0016787   hydrolase activity  
GO:0019556   histidine catabolic process to glutamate and formamide  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 428 1p1m (A) 1 382 16.00 0 1 0.92 0.2
15 424 2gok (A) 18 419 36.00 0 1 1.48 -1.1
5 427 2bb0 (A) 7 415 34.00 0 1 1.39522 -0.43
6 424 2puz (A) 19 419 36.00 0 1 1.39482 -0.39
6 427 2bb0 (A) 8 415 36.00 0 1 1.4448 -0.71
363 428 3ooq (A) 330 389 40.00 0.24 0.97 0.396788 1.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile epimastigote. Smircich P
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_132029)

Species Accession Gene Product
Caenorhabditis elegans CELE_T12A2.1   Protein T12A2.1
Dictyostelium discoideum DDB_G0269854   amidohydrolase domain containing protein 1
Echinococcus granulosus EgrG_001045500   imidazolonepropionase
Echinococcus multilocularis EmuJ_001045500   imidazolonepropionase
Homo sapiens ENSG00000139344   amidohydrolase domain containing 1
Mus musculus ENSMUSG00000015890   amidohydrolase domain containing 1
Schmidtea mediterranea mk4.002594.00  
Trypanosoma cruzi TcCLB.441401.10   imidazolonepropienase, putative
Trypanosoma cruzi TcCLB.509137.30   imidazolonepropionase, putative
Trypanosoma cruzi TcCLB.508741.140   imidazolonepropionase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.509137.30 (Trypanosoma cruzi), imidazolonepropionase, putative
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