pI: 6.5737 |
Length (AA): 452 |
MW (Da): 51630 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
124 | 366 | 1yrb (A) | 499 | 212 | 26.00 | 0 | 0.83 | 0.72 | -0.37 |
129 | 392 | 1yrb (A) | 2 | 239 | 21.00 | 0 | 1 | 0.59 | -0.26 |
130 | 398 | 1yr7 (A) | 3 | 240 | 23.00 | 0.0000051 | 1 | 0.771433 | 0.04 |
131 | 340 | 5hcn (A) | 6 | 188 | 32.00 | 0.000000000013 | 0.87 | 0.614102 | 0.34 |
134 | 264 | 1yr7 (A) | 7 | 110 | 40.00 | 0.0000026 | 0.78 | 0.501323 | 0.13 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | epimastigote. | Smircich P |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128188)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G22370 | early embryo development protein QQT1 |
Babesia bovis | BBOV_IV003790 | ATP binding family protein |
Babesia bovis | BBOV_IV003840 | ATP binding family protein, putative |
Brugia malayi | Bm1_07855 | Conserved hypothetical ATP binding protein |
Candida albicans | CaO19.10678 | similar to S. cerevisiae YOR262W |
Candida albicans | CaO19.3169 | similar to S. cerevisiae YOR262W |
Caenorhabditis elegans | CELE_B0207.6 | Protein B0207.6 |
Cryptosporidium hominis | Chro.70020 | hypothetical protein |
Cryptosporidium parvum | cgd7_80 | XPA1 binding protein-like GTpase |
Dictyostelium discoideum | DDB_G0281787 | GPN-loop GTPase 2 |
Drosophila melanogaster | Dmel_CG10222 | CG10222 gene product from transcript CG10222-RB |
Echinococcus granulosus | EgrG_000894700 | GPN loop GTPase 2 |
Entamoeba histolytica | EHI_108650 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000894700 | GPN loop GTPase 2 |
Giardia lamblia | GL50803_14109 | ATP-binding protein |
Homo sapiens | 54707 | GPN-loop GTPase 2 |
Leishmania braziliensis | LbrM.26.0500 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_260470.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.26.0470 | hypothetical protein, conserved |
Leishmania major | LmjF.26.0480 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.26.0480 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_08306 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02653 | hypothetical protein |
Mus musculus | ENSMUSG00000028848 | GPN-loop GTPase 2 |
Neospora caninum | NCLIV_052100 | hypothetical protein |
Oryza sativa | 4329653 | Os02g0555000 |
Plasmodium berghei | PBANKA_0818700 | GPN-loop GTPase, putative |
Plasmodium falciparum | PF3D7_0917700 | GPN-loop GTPase, putative |
Plasmodium knowlesi | PKNH_0715700 | GPN-loop GTPase, putative |
Plasmodium vivax | PVX_099305 | XPA binding protein 1, putative |
Plasmodium yoelii | PY06079 | similar to unknown protein |
Saccharomyces cerevisiae | YOR262W | Gpn2p |
Schistosoma japonicum | Sjp_0000530 | ko:K06883 ATP binding domain 1 family, member B, putative |
Schistosoma mansoni | Smp_165330 | xpa-binding protein 1-related |
Schmidtea mediterranea | mk4.000466.02 | |
Trypanosoma brucei gambiense | Tbg972.7.1450 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.1450 | Conserved hypothetical ATP binding protein, putative |
Trypanosoma cruzi | TcCLB.503579.40 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.507517.30 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_215090 | ATP binding protein, putative |
Theileria parva | TP01_1015 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_208450 | xpa-binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.1450 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1450 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1450 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.1450 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_B0207.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0207.6 | Caenorhabditis elegans | slow growth | wormbase |
YOR262W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0818700 | Plasmodium berghei | Essential | plasmo |
TGME49_215090 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.