Detailed view for Tb927.10.11380

Basic information

TDR Targets ID: 321689
Trypanosoma brucei, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.8582 | Length (AA): 390 | MW (Da): 44732 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_128797)

Species Accession Gene Product
Arabidopsis thaliana AT1G04130   carboxylate clamp-tetratricopeptide repeat protein
Babesia bovis BBOV_III007820   conserved hypothetical protein
Brugia malayi Bm1_35685   Tetratricopeptide repeat protein 4
Candida albicans CaO19.13473   component of Hsp90 chaperone complex
Candida albicans CaO19.6052   component of Hsp90 chaperone complex
Caenorhabditis elegans CELE_C17G10.2   Protein C17G10.2
Cryptosporidium hominis Chro.70071   tetratricopeptide repeat domain 4
Cryptosporidium parvum cgd7_570   protein with 2 TPR domains
Dictyostelium discoideum DDB_G0286253   tetratricopeptide repeat domain 4
Drosophila melanogaster Dmel_CG3189   DNA polymerase interacting tpr containing protein of 47kD
Echinococcus granulosus EgrG_000683500   tetratricopeptide repeat protein 4
Entamoeba histolytica EHI_189950   co-chaperone protein, putative
Echinococcus multilocularis EmuJ_000683500   tetratricopeptide repeat protein 4
Homo sapiens ENSG00000243725   tetratricopeptide repeat domain 4
Leishmania braziliensis LbrM.33.0740   hypothetical protein, conserved
Leishmania donovani LdBPK_330750.1   hypothetical protein, conserved
Leishmania infantum LinJ.33.0750   hypothetical protein, conserved
Leishmania major LmjF.33.0700   hypothetical protein, conserved
Leishmania mexicana LmxM.32.0700   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_11070   hypothetical protein
Mus musculus ENSMUSG00000025413   tetratricopeptide repeat domain 4
Neospora caninum NCLIV_002110   TPR domain-containing protein, putative
Oryza sativa 4334120   Os03g0750100
Onchocerca volvulus OVOC11314  
Saccharomyces cerevisiae YBR155W   Cns1p
Schistosoma japonicum Sjp_0303150   Tetratricopeptide repeat protein 4, putative
Schistosoma mansoni Smp_155480   heat shock protein 70
Schmidtea mediterranea mk4.000120.17   Tetratricopeptide repeat protein 4
Trypanosoma brucei gambiense Tbg972.10.13740   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.11380   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_9610   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506577.70   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507709.70   hypothetical protein, conserved
Toxoplasma gondii TGME49_295730   tetratricopeptide repeat-containing protein
Trichomonas vaginalis TVAG_390540   heat shock protein 70 (HSP70)-interacting protein, putative
Trichomonas vaginalis TVAG_459190   heat shock protein 70 (HSP70)-interacting protein, putative

Essentiality

Tb927.10.11380 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.11380 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.11380 this record Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.11380 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.11380 this record Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C17G10.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C17G10.2 Caenorhabditis elegans larval lethal wormbase
CELE_C17G10.2 Caenorhabditis elegans slow growth wormbase
YBR155W Saccharomyces cerevisiae inviable yeastgenome
TGME49_295730 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) increased (PATO:0000470) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) increased (PATO:0000470) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.10.11380 (Trypanosoma brucei), hypothetical protein, conserved
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