Detailed view for Tb927.10.4500

Basic information

TDR Targets ID: 321732
Trypanosoma brucei, cap guanine-N7 methyltransferase
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.8008 | Length (AA): 312 | MW (Da): 35632 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03291   mRNA capping enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0006370   mRNA capping  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_145248)

Species Accession Gene Product
Leishmania braziliensis LbrM.35.0190   mRNA capping methyltransferase, putative
Leishmania donovani LdBPK_360130.1   cap guanine-N7 methyltransferase
Leishmania infantum LinJ.36.0130   mRNA capping methyltransferase, putative
Leishmania major LmjF.36.0120   mRNA capping methyltransferase, putative
Leishmania mexicana LmxM.36.0120   mRNA capping methyltransferase, putative
Trypanosoma brucei gambiense Tbg972.10.5530   mRNA capping methyltransferase, putative
Trypanosoma brucei Tb10.v4.0040   mRNA capping methyltransferase, putative
Trypanosoma brucei Tb927.10.4500   cap guanine-N7 methyltransferase
Trypanosoma congolense TcIL3000_10_3700   cap guanine-N7 methyltransferase
Trypanosoma cruzi TcCLB.508625.70   cap guanine-N7 methyltransferase
Trypanosoma cruzi TcCLB.510963.30   cap guanine-N7 methyltransferase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Tb927.10.4500 (Trypanosoma brucei), cap guanine-N7 methyltransferase
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