Detailed view for Tb927.10.8950

Basic information

TDR Targets ID: 321760
Trypanosoma brucei, kinetoplast-associated protein 4 isoform 1
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.4618 | Length (AA): 126 | MW (Da): 14184 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
64 186 3tq6 (A) 47 197 28.00 0.00000000018 0.45 0.67269 0.27
71 180 2yrq (A) 20 142 18.00 0.0000000016 0.92 0.764798 -0.18
134 186 1v64 (A) 8 60 25.00 0.14 0.75 0.720346 -1.17
135 186 1k99 (A) 2 57 21.00 0.036 0.48 0.54097 -0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Procyclic. Siegel TN
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_138924)

Species Accession Gene Product
Leishmania braziliensis LbrM.35.6130   kinetoplast-associated protein, putative
Leishmania donovani LdBPK_366100.1   kinetoplast-associated protein, putative
Leishmania infantum LinJ.36.6100   kinetoplast-associated protein, putative
Leishmania major LmjF.36.5845   kinetoplast-associated protein, putative
Leishmania mexicana LmxM.36.5845   kinetoplast-associated protein, putative
Trypanosoma brucei gambiense Tbg972.10.10950   kinetoplast DNA-associated protein, putative
Trypanosoma brucei gambiense Tbg972.10.10970   kinetoplast DNA-associated protein, putative
Trypanosoma brucei Tb927.10.8970   kinetoplast-associated protein 4 isoform 2
Trypanosoma brucei Tb927.10.8950   kinetoplast-associated protein 4 isoform 1
Trypanosoma congolense TcIL3000_10_7740   kinetoplast DNA-associated protein, putative
Trypanosoma cruzi TcCLB.509793.30   kinetoplast DNA-associated protein, putative
Trypanosoma cruzi TcCLB.508719.60   kinetoplast DNA-associated protein, putative
Trypanosoma cruzi TcCLB.508719.40   kinetoplast DNA-associated protein, putative
Trypanosoma cruzi TcCLB.509793.40   kinetoplast-associated protein
Trypanosoma cruzi TcCLB.509793.10   kinetoplast-associated protein 4

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb927.10.8950 (Trypanosoma brucei), kinetoplast-associated protein 4 isoform 1
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