pI: 10.1982 |
Length (AA): 114 |
MW (Da): 13188 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
31 | 101 | 4rng (A) | 13 | 80 | 38.00 | 0.045 | 0.06 | 0.402521 | 1.77 |
10 | 77 | 1lnq (A) | 20 | 81 | 8.00 | 0 | 0 | 0.321278 | 1.15 |
69 | 121 | 4xnv (A) | 59 | 115 | 28.00 | 0.38 | 0.03 | 0.461196 | 1.37 |
2 | 31 | 4tlm (C) | 783 | 826 | 7.00 | 0 | 0 | -0.133042 | 3.46 |
45 | 104 | 3oqg (A) | 39 | 95 | 32.00 | 0.82 | 0.05 | 0.542516 | 2.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | intra-erythrocytic - 16 hs, Ring. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Female Gametocyte. | Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 24 hs, Male Gametocyte. | Otto TD Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 8 hs, Sporozoite. | Otto TD Zanghi G |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_128566)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G59470 | mannose-P-dolichol utilization defect 1 protein |
Arabidopsis thaliana | AT4G07390 | mannose-P-dolichol utilization defect 1 protein |
Brugia malayi | Bm1_30690 | PQ loop repeat family protein |
Candida albicans | CaO19.899 | similar to D. melanogaster CG3792 gene product |
Candida albicans | CaO19.8518 | similar to D. melanogaster CG3792 gene product |
Caenorhabditis elegans | CELE_F38E1.9 | Protein F38E1.9 |
Cryptosporidium hominis | Chro.20063 | MPU1p |
Cryptosporidium parvum | cgd2_550 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0295677 | cystinosin/ERS1p repeat-containing protein |
Drosophila melanogaster | Dmel_CG3792 | CG3792 gene product from transcript CG3792-RA |
Echinococcus granulosus | EgrG_000848400 | mannose P dolichol utilization defect 1 protein |
Entamoeba histolytica | EHI_035970 | PQ loop repeat protein |
Echinococcus multilocularis | EmuJ_000848400 | mannose P dolichol utilization defect 1 protein |
Homo sapiens | ENSG00000129255 | mannose-P-dolichol utilization defect 1 |
Leishmania braziliensis | LbrM.14.1080 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_141160.1 | PQ loop repeat, putative |
Leishmania infantum | LinJ.14.1160 | hypothetical protein, conserved |
Leishmania major | LmjF.14.1090 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.14.1090 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_05971 | PQ loop repeat family protein |
Mus musculus | ensembl-mmu:ENSMUSG00000018761 | mannose-P-dolichol utilization defect 1 |
Neospora caninum | NCLIV_007850 | hypothetical protein |
Oryza sativa | 4343225 | Os07g0479200 |
Plasmodium berghei | PBANKA_0913500 | PQ-loop repeat-containing protein |
Plasmodium falciparum | PF3D7_1135000 | PQ-loop repeat-containing protein, unspecified product |
Plasmodium vivax | PVX_092360 | PQ loop repeat family protein |
Schistosoma japonicum | Sjp_0304790 | ko:K09660 mannose-P-dolichol utilization defect 1, putative |
Schistosoma mansoni | Smp_155700 | mannose-p-dolichol utilization defect 1 (lec35)-related |
Schmidtea mediterranea | mk4.000904.06 | Mannose-P-dolichol utilization defect 1 protein homolog |
Trypanosoma brucei gambiense | Tbg972.7.4310 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.3860 | PQ loop repeat, putative |
Trypanosoma congolense | TcIL3000_7_3120 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511249.90 | PQ loop repeat, putative |
Toxoplasma gondii | TGME49_253420 | PQ loop repeat-containing protein |
Trichomonas vaginalis | TVAG_339310 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.3860 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3860 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3860 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.3860 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_253420 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.