Detailed view for PF3D7_API02500

Basic information

TDR Targets ID: 322065
Plasmodium falciparum, apicoplast ribosomal protein L36
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 11.4578 | Length (AA): 36 | MW (Da): 4396 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00444   Ribosomal protein L36

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 36 1dfe (A) 1 36 56.00 0.00000000038 1 1.4185 2.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_128944)

Species Accession Gene Product
Arabidopsis thaliana AT5G20180   ribosomal protein L36
Arabidopsis thaliana ArthCp057   50S ribosomal protein L36
Brugia malayi Bm1_54665   ribosomal protein L36 containing protein
Candida albicans CaO19.760   likely mitochondrial ribosomal protein similar to S. cerevisiae GON5 (YPL183W-A) putative mitochondrial ribosomal protein (E. co
Candida albicans CaO19.8380   likely mitochondrial ribosomal protein similar to S. cerevisiae GON5 (YPL183W-A) putative mitochondrial ribosomal protein (E. co
Caenorhabditis elegans CELE_K11H3.6   Protein MRPL-36
Dictyostelium discoideum DDB_G0280799   hypothetical protein
Drosophila melanogaster Dmel_CG18767   mitochondrial ribosomal protein L36
Escherichia coli b3299   50S ribosomal subunit protein L36
Echinococcus granulosus EgrG_000456900   mitochondrial ribosomal protein l36
Echinococcus multilocularis EmuJ_000456900   mitochondrial ribosomal protein l36
Homo sapiens ENSG00000171421   mitochondrial ribosomal protein L36
Loa Loa (eye worm) LOAG_06130   ribosomal protein L36 containing protein
Mycobacterium leprae ML1961c   PROBABLE 50S RIBOSOMAL PROTEIN L36 RPMJ
Mus musculus ENSMUSG00000021607   mitochondrial ribosomal protein L36
Mycobacterium tuberculosis Rv3461c   50S ribosomal protein L36 RpmJ
Mycobacterium ulcerans MUL_0844   50S ribosomal protein L36
Oryza sativa 4334544   Os03g0811800
Oryza sativa 3131430   50S ribosomal protein L36
Plasmodium berghei PBANKA_API00310   apicoplast ribosomal protein L36
Plasmodium falciparum PF3D7_API02500   apicoplast ribosomal protein L36
Plasmodium knowlesi PKNH_API03400   apicoplast ribosomal protein L36, putative
Saccharomyces cerevisiae YPL183W-A   putative mitochondrial 54S ribosomal protein RTC6
Schistosoma japonicum Sjp_0048690   IPR000473,Ribosomal protein L36,domain-containing
Schistosoma mansoni Smp_091170   hypothetical protein
Treponema pallidum TP0209   50S ribosomal protein L36
Theileria parva TP05_0015   ribosomal protein L36, putative

Essentiality

PF3D7_API02500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3299 Escherichia coli essential goodall
CELE_K11H3.6 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_API02500 (Plasmodium falciparum), apicoplast ribosomal protein L36
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