Detailed view for PVX_241290

Basic information

TDR Targets ID: 322141
Plasmodium vivax, unspecified product
Source Database / ID:  PlasmoDB 

pI: 8.4111 | Length (AA): 771 | MW (Da): 89418 | Paralog Number: 114

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05795   Plasmodium vivax Vir protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016987   sigma factor activity  
GO:0003700   transcription factor activity  
GO:0003677   DNA binding  
GO:0006352   transcription initiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
262 525 4u0r (A) 177 495 13.00 0.047 0.24 0.406112 -0.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127519)

Species Accession Gene Product
Caenorhabditis elegans CELE_Y49E10.10   Protein Y49E10.10
Plasmodium vivax PVX_002485   variable surface protein Vir12-related
Plasmodium vivax PVX_017140   unspecified product
Plasmodium vivax PVX_077695   unspecified product
Plasmodium vivax PVX_107740   unspecified product
Plasmodium vivax PVX_086865   VIR protein
Plasmodium vivax PVX_065690   unspecified product
Plasmodium vivax PVX_001635   VIR protein
Plasmodium vivax PVX_074690   unspecified product
Plasmodium vivax PVX_018660   unspecified product
Plasmodium vivax PVX_124705   variable surface protein Vir12-related
Plasmodium vivax PVX_005045   variable surface protein Vir12-related
Plasmodium vivax PVX_108765   unspecified product
Plasmodium vivax PVX_090310   VIR protein
Plasmodium vivax PVX_119210   variant surface protein Vir22/5/24, putative
Plasmodium vivax PVX_094245   variable surface protein Vir12-like
Plasmodium vivax PVX_094240   variable surface protein Vir12/24-related
Plasmodium vivax PVX_120845   unspecified product
Plasmodium vivax PVX_023185   unspecified product
Plasmodium vivax PVX_049690   unspecified product
Plasmodium vivax PVX_041690   unspecified product
Plasmodium vivax PVX_107755   unspecified product
Plasmodium vivax PVX_005055   VIR protein
Plasmodium vivax PVX_124720   variable surface protein Vir12-related
Plasmodium vivax PVX_007085   unspecified product
Plasmodium vivax PVX_090315   variable surface protein Vir12-like
Plasmodium vivax PVX_097555   variable surface protein Vir12/16-related
Plasmodium vivax PVX_088805   variable surface protein Vir22/24-like
Plasmodium vivax PVX_110295   variable surface protein Vir22-like
Plasmodium vivax PVX_076195   unspecified product
Plasmodium vivax PVX_042190   unspecified product
Plasmodium vivax PVX_005060   variable surface protein Vir12-like
Plasmodium vivax PVX_096920   variable surface protein Vir12-related
Plasmodium vivax PVX_015635   unspecified product
Plasmodium vivax PVX_088780   variable surface protein Vir24-related
Plasmodium vivax PVX_020170   unspecified product
Plasmodium vivax PVX_061690   unspecified product
Plasmodium vivax PVX_104180   unspecified product
Plasmodium vivax PVX_002490   variable surface protein Vir12-related
Plasmodium vivax PVX_107745   unspecified product
Plasmodium vivax PVX_183280   unspecified product
Plasmodium vivax PVX_241290   unspecified product
Plasmodium vivax PVX_090295   VIR protein
Plasmodium vivax PVX_097530   variable surface protein Vir22/12-related
Plasmodium vivax PVX_104190   unspecified product
Plasmodium vivax PVX_097545   variable surface protein Vir12-related
Plasmodium vivax PVX_081850   variable surface protein Vir22/23-related
Plasmodium vivax PVX_097525   variable surface protein Vir 12, putative
Plasmodium vivax PVX_063190   unspecified product
Plasmodium vivax PVX_133260   unspecified product
Plasmodium vivax PVX_090305   variable surface protein Vir12-related
Plasmodium vivax PVX_004495   VIR protein
Plasmodium vivax PVX_096910   variable surface protein Vir23-related
Plasmodium vivax PVX_103155   variable surface protein Vir12-related
Plasmodium vivax PVX_010105   unspecified product
Plasmodium vivax PVX_124715   variable surface protein Vir5-related
Plasmodium vivax PVX_115490   VIR protein
Plasmodium vivax PVX_022685   unspecified product
Plasmodium vivax PVX_009595   unspecified product
Plasmodium vivax PVX_078195   unspecified product
Plasmodium vivax PVX_088795   VIR protein
Plasmodium vivax PVX_093720   variable surface protein Vir24-like
Plasmodium vivax PVX_003490   VIR protein
Plasmodium vivax PVX_086895   VIR protein
Plasmodium vivax PVX_112720   unspecified product
Plasmodium vivax PVX_086893   VIR protein
Plasmodium vivax PVX_093735   VIR protein
Plasmodium vivax PVX_125726   unspecified product
Plasmodium vivax PVX_027190   unspecified product
Plasmodium vivax PVX_157260   unspecified product
Plasmodium vivax PVX_086855   variable surface protein Vir24-like
Plasmodium vivax PVX_001640   VIR protein
Plasmodium vivax PVX_097542   VIR protein
Plasmodium vivax PVX_110300   variable surface protein Vir21, putative
Plasmodium vivax PVX_170270   unspecified product
Plasmodium vivax PVX_086860   variable surface protein Vir24-related
Plasmodium vivax PVX_037690   unspecified product
Plasmodium vivax PVX_036690   unspecified product
Plasmodium vivax PVX_001645   variable surface protein Vir12-related
Plasmodium vivax PVX_101630   VIR protein
Plasmodium vivax PVX_024685   unspecified product
Plasmodium vivax PVX_054190   unspecified product
Plasmodium vivax PVX_090290   variable surface protein Vir12, putative
Plasmodium vivax PVX_001625   variable surface protein Vir12-related
Plasmodium vivax PVX_003505   variable surface protein Vir24-related
Plasmodium vivax PVX_003495   variable surface protein Vir22/24-related
Plasmodium vivax PVX_096003   VIR protein
Plasmodium vivax PVX_172270   unspecified product
Plasmodium vivax PVX_022185   unspecified product
Plasmodium vivax PVX_083580   variable surface protein Vir24-related
Plasmodium vivax PVX_034690   unspecified product
Plasmodium vivax PVX_004537   VIR protein
Plasmodium vivax PVX_115985   unspecified product
Plasmodium vivax PVX_083590   variable surface protein Vir12, putative
Plasmodium vivax PVX_106220   variable surface protein Vir12, putative
Plasmodium vivax PVX_094250   VIR protein
Plasmodium vivax PVX_038190   unspecified product
Plasmodium vivax PVX_134260   unspecified product
Plasmodium vivax PVX_075695   unspecified product
Plasmodium vivax PVX_158260   unspecified product
Plasmodium vivax PVX_124725   VIR protein
Plasmodium vivax PVX_004530   VIR protein
Plasmodium vivax PVX_013620   unspecified product
Plasmodium vivax PVX_115480   variable surface protein Vir21, putative
Plasmodium vivax PVX_003510   variable surface protein Vir24-related
Plasmodium vivax PVX_107235   unspecified product
Plasmodium vivax PVX_107735   unspecified product
Plasmodium vivax PVX_020680   unspecified product
Plasmodium vivax PVX_102640   unspecified product
Plasmodium vivax PVX_002480   variable surface protein Vir12/24-related
Plasmodium vivax PVX_074190   unspecified product
Plasmodium vivax PVX_096001   VIR protein
Plasmodium vivax PVX_005057   VIR protein
Plasmodium vivax PVX_120340   unspecified product
Plasmodium vivax PVX_106725   unspecified product
Plasmodium vivax PVX_073690   unspecified product

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_241290 (Plasmodium vivax), unspecified product
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