Detailed view for PVX_198290

Basic information

TDR Targets ID: 322149
Plasmodium vivax, unspecified product
Source Database / ID:  PlasmoDB 

pI: 10.3731 | Length (AA): 531 | MW (Da): 60962 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00270   DEAD/DEAH box helicase
PF00271   Helicase conserved C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008026   ATP-dependent helicase activity  
GO:0005524   ATP binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 76 2j7j (A) 13 85 7.00 0.00045 0 0.23701 -0.88
122 518 4ljy (A) 256 586 32.00 0 1 0.699146 1.29
129 335 3bor (A) 38 221 39.00 0.0000000000055 1 0.713331 -0.53
142 330 1wrb (A) 202 379 39.00 0 1 0.809432 -0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128047)

Species Accession Gene Product
Arabidopsis thaliana AT3G16840   P-loop containing nucleoside triphosphate hydrolases superfamily protein
Babesia bovis BBOV_IV001200   DEAD/DEAH box helicase, putative
Brugia malayi Bm1_54000   DEAD/DEAH box helicase family protein
Candida albicans CaO19.3540   ATP-dependent RNA helicase
Candida albicans CaO19.11024   ATP-dependent RNA helicase
Caenorhabditis elegans CELE_F55F8.2   Protein F55F8.2, isoform B
Cryptosporidium hominis Chro.80030   DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 24
Cryptosporidium parvum cgd8_190   Mak5 pre-mRNA splicing RNA SFII helicase
Dictyostelium discoideum DDB_G0281841   DEAD/DEAH box helicase
Drosophila melanogaster Dmel_CG9143   CG9143 gene product from transcript CG9143-RA
Echinococcus granulosus EgrG_000086400   DEAD box ATP dependent RNA helicase 13
Entamoeba histolytica EHI_145050   DEAD/DEAH box helicase, putative
Echinococcus multilocularis EmuJ_000086400   DEAD box ATP dependent RNA helicase 13
Giardia lamblia GL50803_13220   ATP-dependent RNA helicase
Homo sapiens ENSG00000089737   DEAD (Asp-Glu-Ala-Asp) box helicase 24
Leishmania braziliensis LbrM.35.4640   ATP-dependent RNA helicase-like protein
Leishmania donovani LdBPK_364620.1   ATP-dependent DEAD/H RNA helicase, putative
Leishmania infantum LinJ.36.4620   ATP-dependent RNA helicase-like protein
Leishmania major LmjF.36.4400   ATP-dependent RNA helicase-like protein
Leishmania mexicana LmxM.36.4400   ATP-dependent RNA helicase-like protein
Loa Loa (eye worm) LOAG_16125   hypothetical protein
Loa Loa (eye worm) LOAG_10144   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000041645   DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
Neospora caninum NCLIV_036150   hypothetical protein
Oryza sativa 4336370   Os04g0510400
Plasmodium berghei PBANKA_1309000   ATP-dependent RNA helicase MAK5, putative
Plasmodium falciparum PF3D7_1445200   ATP-dependent RNA helicase MAK5, putative
Plasmodium knowlesi PKNH_1237100   ATP-dependent RNA helicase MAK5, putative
Plasmodium vivax PVX_118230   RNA helicase, putative
Plasmodium vivax PVX_198290   unspecified product
Plasmodium yoelii PY07373   ATP-dependent RNA helicase
Saccharomyces cerevisiae YBR142W   Mak5p
Schistosoma japonicum Sjp_0081920   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma mansoni Smp_131360   DEAD box ATP-dependent RNA helicase
Schmidtea mediterranea mk4.000337.09   ATP-dependent RNA helicase DDX24
Schmidtea mediterranea mk4.000337.08   ATP-dependent RNA helicase DDX24
Trypanosoma brucei gambiense Tbg972.10.11950   ATP-dependent DEAD/H RNA helicase, putative,ATP- dependent RNA helicase, putative
Trypanosoma brucei Tb927.10.9780   ATP-dependent DEAD/H RNA helicase, putative
Trypanosoma congolense TcIL3000_10_8570   ATP-dependent DEAD/H RNA helicase, putative
Trypanosoma cruzi TcCLB.504147.150   ATP-dependent DEAD/H RNA helicase, putative
Toxoplasma gondii TGME49_270620   DEAD/DEAH box helicase domain-containing protein
Theileria parva TP01_0146   ATP-dependent RNA helicase, putative

Essentiality

PVX_198290 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.9780 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.9780 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.9780 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.9780 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F55F8.2 Caenorhabditis elegans larval arrest wormbase
CELE_F55F8.2 Caenorhabditis elegans slow growth wormbase
YBR142W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1309000 Plasmodium berghei Essential plasmo
TGME49_270620 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_198290 (Plasmodium vivax), unspecified product
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