Detailed view for PVX_175270

Basic information

TDR Targets ID: 322269
Plasmodium vivax, unspecified product
Source Database / ID:  PlasmoDB 

pI: 8.2247 | Length (AA): 332 | MW (Da): 38305 | Paralog Number: 38

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05795   Plasmodium vivax Vir protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 261 4k2u (B) 25 280 13.00 0.89 0.21 0.861319 -0.28
70 210 2g9h (D) 97 210 30.00 0.39 0.05 0.398899 0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132062)

Species Accession Gene Product
Plasmodium vivax PVX_076695   unspecified product
Plasmodium vivax PVX_105700   unspecified product
Plasmodium vivax PVX_072690   unspecified product
Plasmodium vivax PVX_004520   variable surface protein Vir4, putative
Plasmodium vivax PVX_101560   variable surface protein Vir4-related
Plasmodium vivax PVX_004525   variable surface protein Vir16/32-related
Plasmodium vivax PVX_061190   unspecified product
Plasmodium vivax PVX_030190   unspecified product
Plasmodium vivax PVX_029190   unspecified product
Plasmodium vivax PVX_044190   unspecified product
Plasmodium vivax PVX_027690   unspecified product
Plasmodium vivax PVX_005575   unspecified product
Plasmodium vivax PVX_088800   variable surface protein Vir4-related
Plasmodium vivax PVX_088798   VIR protein
Plasmodium vivax PVX_169270   unspecified product
Plasmodium vivax PVX_003485   variable surface protein Vir4, putative
Plasmodium vivax PVX_149260   unspecified product
Plasmodium vivax PVX_028190   unspecified product
Plasmodium vivax PVX_127260   unspecified product
Plasmodium vivax PVX_021680   unspecified product
Plasmodium vivax PVX_026190   unspecified product
Plasmodium vivax PVX_095995   variable surface protein Vir16/32-related
Plasmodium vivax PVX_095990   VIR protein
Plasmodium vivax PVX_086875   variable surface protein Vir27-related
Plasmodium vivax PVX_096000   variable surface protein Vir4, putative
Plasmodium vivax PVX_051690   unspecified product
Plasmodium vivax PVX_010610   unspecified product
Plasmodium vivax PVX_102125   unspecified product
Plasmodium vivax PVX_009090   unspecified product
Plasmodium vivax PVX_184285   unspecified product
Plasmodium vivax PVX_175270   unspecified product
Plasmodium vivax PVX_050190   unspecified product
Plasmodium vivax PVX_006580   unspecified product
Plasmodium vivax PVX_103665   unspecified product
Plasmodium vivax PVX_096945   variable surface protein Vir4-related
Plasmodium vivax PVX_043690   unspecified product
Plasmodium vivax PVX_016140   unspecified product
Plasmodium vivax PVX_104185   unspecified product
Plasmodium vivax PVX_005580   unspecified product

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_175270 (Plasmodium vivax), unspecified product
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