pI: 8.5106 |
Length (AA): 328 |
MW (Da): 34812 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
77 | 153 | 2gs5 (A) | 119 | 187 | 38.00 | 0.26 | 0.08 | 0.124456 | 1.64 |
81 | 308 | 1t9f (A) | 0 | 197 | 27.00 | 0 | 0.98 | 0.759622 | -0.08 |
85 | 311 | 3mal (A) | 36 | 212 | 31.00 | 0 | 0.73 | 0.779573 | -0.06 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite. | Gregory |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite, ME49 merozoite, ME49 Bradyzoite. | Gregory Hehl AB Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Oocyst. | Fritz HM |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_129318)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G25110 | stromal cell-derived factor 2-like protein |
Brugia malayi | Bm1_50165 | MIR domain containing protein |
Caenorhabditis elegans | CELE_R12E2.13 | Protein R12E2.13 |
Cryptosporidium hominis | Chro.80250 | hypothetical protein |
Cryptosporidium parvum | cgd8_2110 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0284847 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11999 | CG11999 gene product from transcript CG11999-RA |
Echinococcus granulosus | EgrG_001176500 | stromal cell derived factor 2 |
Entamoeba histolytica | EHI_100480 | MIR domain protein |
Echinococcus multilocularis | EmuJ_001176500 | stromal cell derived factor 2 |
Homo sapiens | ENSG00000132581 | stromal cell-derived factor 2 |
Homo sapiens | ENSG00000128228 | stromal cell-derived factor 2-like 1 |
Loa Loa (eye worm) | LOAG_06469 | MIR domain-containing protein |
Mus musculus | ENSMUSG00000002064 | stromal cell derived factor 2 |
Mus musculus | ENSMUSG00000022769 | stromal cell-derived factor 2-like 1 |
Neospora caninum | NCLIV_044950 | hypothetical protein, conserved |
Oryza sativa | 4345684 | Os08g0440500 |
Oryza sativa | 4345160 | Os08g0278900 |
Onchocerca volvulus | OVOC517 |
|
Plasmodium berghei | PBANKA_1209100 | dolichyl-phosphate-mannose protein mannosyltransferase, putative |
Plasmodium falciparum | PF3D7_1010700 | dolichyl-phosphate-mannose protein mannosyltransferase, putative |
Plasmodium knowlesi | PKNH_0810500 | dolichyl-phosphate-mannose protein mannosyltransferase, putative |
Plasmodium vivax | PVX_094755 | hypothetical protein, conserved |
Plasmodium yoelii | PY02090 | hypothetical protein |
Schistosoma japonicum | Sjp_0002550 | Stromal cell-derived factor 2 precursor, putative |
Schistosoma mansoni | Smp_170920 | stromal cell-derived factor 2 precursor-like protein |
Schmidtea mediterranea | mk4.034732.00 | Stromal cell-derived factor 2-like protein |
Toxoplasma gondii | TGME49_228630 | hypothetical protein |
Trichomonas vaginalis | TVAG_455070 | mannosyltransferase, putative |
Trichomonas vaginalis | TVAG_494110 | mannosyltransferase, putative |
Trichomonas vaginalis | TVAG_028970 | mannosyltransferase 1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_228630 this record | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.