Detailed view for Smp_089000.2

Basic information

TDR Targets ID: 324107
Schistosoma mansoni, translocon-associated protein delta subunit

Source Database / ID:  GeneDB

pI: 8.4596 | Length (AA): 162 | MW (Da): 17916 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05404   Translocon-associated protein, delta subunit precursor (TRAP-delta)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005783   endoplasmic reticulum  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 148 3p9z (A) 20 148 33.00 0.18 0.5 0.951298 0.87
32 113 1w4v (A) 12 107 26.00 0.93 0.63 0.666573 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133099)

Species Accession Gene Product
Brugia malayi Bm1_39305   Translocon-associated protein, delta subunit precursor, putative
Caenorhabditis elegans CELE_Y56A3A.21   Protein TRAP-4
Drosophila melanogaster Dmel_CG9035   Translocon-associated protein delta
Echinococcus granulosus EgrG_000391800   translocon associated protein subunit delta
Echinococcus multilocularis EmuJ_000391800   Translocon associated
Homo sapiens ENSG00000180879   signal sequence receptor, delta
Loa Loa (eye worm) LOAG_00247   hypothetical protein
Mus musculus ENSMUSG00000002014   signal sequence receptor, delta
Schistosoma japonicum Sjp_0004120   ko:K04571 signal sequence receptor, delta (translocon-associated protein, putative
Schistosoma japonicum Sjp_0200680   ko:K04571 signal sequence receptor, delta (translocon-associated protein, putative
Schistosoma mansoni Smp_089000.2   translocon-associated protein delta subunit
Schistosoma mansoni Smp_089000.1   translocon-associated protein delta subunit
Schmidtea mediterranea mk4.001672.04   TRAPD

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_089000.2 (Schistosoma mansoni), translocon-associated protein delta subunit
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