Detailed view for Smp_108390
Basic information
TDR Targets ID: 324244
Schistosoma mansoni, histone H2B
Source Database / ID: GeneDB
Schistosoma mansoni, histone H2B
Source Database / ID: GeneDB
pI: 11.0853 |
Length (AA): 122 |
MW (Da): 13575 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00125
Core histone H2A/H2B/H3/H4
Gene Ontology
Mouse over links to read term descriptions.
GO:0046982
protein heterodimerization activity GO:0005634 nucleus
GO:0000786 nucleosome
GO:0003677 DNA binding
GO:0006334 nucleosome assembly
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
No model available for this protein in Modbase.
PDB Structures:
No structure availble in the PDB for this protein
Expression
No expression data available for this gene
Orthologs
Ortholog group members (OG5_126572)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT5G59910 | histone H2B |
| Arabidopsis thaliana | AT3G45980 | histone HTB9 |
| Arabidopsis thaliana | AT1G07790 | histone H2B |
| Arabidopsis thaliana | AT2G28720 | histone H2B |
| Arabidopsis thaliana | AT3G09480 | histone H2B |
| Arabidopsis thaliana | AT5G22880 | histone H2B |
| Arabidopsis thaliana | AT2G37470 | histone H2B |
| Arabidopsis thaliana | AT5G02570 | histone H2B |
| Arabidopsis thaliana | AT3G53650 | histone H2B |
| Arabidopsis thaliana | AT3G46030 | histone HTB11 |
| Babesia bovis | BBOV_II001750 | histone 2B protein, putative |
| Babesia bovis | BBOV_IV006840 | histone H2B.1, putative |
| Brugia malayi | Bm1_20280 | Probable histone H2B 3 |
| Brugia malayi | Bm1_02800 | Histone H2B 2 |
| Brugia malayi | Bm1_03575 | Probable histone H2B 4 |
| Brugia malayi | Bm1_02510 | histone H2B 2 |
| Candida albicans | CaO19.8654 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
| Candida albicans | CaO19.6925 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
| Candida albicans | CaO19.14187 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
| Candida albicans | CaO19.1052 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
| Caenorhabditis elegans | CELE_C50F4.5 | Protein HIS-41 |
| Caenorhabditis elegans | CELE_F55G1.3 | Protein HIS-62 |
| Caenorhabditis elegans | CELE_F54E12.4 | Protein HIS-58 |
| Caenorhabditis elegans | CELE_B0035.8 | Protein HIS-48 |
| Caenorhabditis elegans | CELE_H02I12.6 | Protein HIS-66 |
| Caenorhabditis elegans | CELE_K06C4.12 | Protein HIS-22 |
| Caenorhabditis elegans | CELE_ZK131.9 | Protein HIS-15 |
| Caenorhabditis elegans | CELE_T10C6.11 | Protein HIS-4 |
| Caenorhabditis elegans | CELE_F07B7.4 | Protein HIS-52 |
| Caenorhabditis elegans | CELE_F07B7.11 | Protein HIS-54 |
| Caenorhabditis elegans | CELE_F35H10.11 | Protein HIS-29 |
| Caenorhabditis elegans | CELE_F08G2.1 | Protein HIS-44 |
| Caenorhabditis elegans | CELE_F45F2.12 | Protein HIS-8 |
| Caenorhabditis elegans | CELE_ZK131.5 | Protein HIS-11 |
| Caenorhabditis elegans | CELE_K06C4.4 | Protein HIS-20 |
| Caenorhabditis elegans | CELE_F17E9.9 | Protein HIS-34 |
| Cryptosporidium hominis | Chro.70200 | histone H2B variant 1 |
| Cryptosporidium hominis | Chro.50055 | histone H2B |
| Cryptosporidium parvum | cgd5_3170 | histone H2B |
| Cryptosporidium parvum | cgd7_1700 | histone H2B |
| Dictyostelium discoideum | DDB_G0286509 | histone H2B domain-containing protein |
| Drosophila melanogaster | Dmel_CG33870 | CG33870 gene product from transcript CG33870-RA |
| Drosophila melanogaster | Dmel_CG33872 | CG33872 gene product from transcript CG33872-RA |
| Drosophila melanogaster | Dmel_CG33888 | CG33888 gene product from transcript CG33888-RA |
| Drosophila melanogaster | Dmel_CG33904 | CG33904 gene product from transcript CG33904-RA |
| Drosophila melanogaster | Dmel_CG33908 | CG33908 gene product from transcript CG33908-RA |
| Drosophila melanogaster | Dmel_CG33890 | CG33890 gene product from transcript CG33890-RA |
| Drosophila melanogaster | Dmel_CG33900 | CG33900 gene product from transcript CG33900-RA |
| Drosophila melanogaster | Dmel_CG33880 | CG33880 gene product from transcript CG33880-RA |
| Drosophila melanogaster | Dmel_CG33906 | CG33906 gene product from transcript CG33906-RA |
| Drosophila melanogaster | Dmel_CG33868 | CG33868 gene product from transcript CG33868-RA |
| Drosophila melanogaster | Dmel_CG33898 | CG33898 gene product from transcript CG33898-RA |
| Drosophila melanogaster | Dmel_CG33886 | CG33886 gene product from transcript CG33886-RA |
| Drosophila melanogaster | Dmel_CG33910 | CG33910 gene product from transcript CG33910-RA |
| Drosophila melanogaster | Dmel_CG33902 | CG33902 gene product from transcript CG33902-RA |
| Drosophila melanogaster | Dmel_CG33884 | CG33884 gene product from transcript CG33884-RA |
| Drosophila melanogaster | Dmel_CG33878 | CG33878 gene product from transcript CG33878-RA |
| Drosophila melanogaster | Dmel_CG33896 | CG33896 gene product from transcript CG33896-RA |
| Drosophila melanogaster | Dmel_CG33892 | CG33892 gene product from transcript CG33892-RA |
| Drosophila melanogaster | Dmel_CG17949 | CG17949 gene product from transcript CG17949-RA |
| Drosophila melanogaster | Dmel_CG33882 | CG33882 gene product from transcript CG33882-RA |
| Drosophila melanogaster | Dmel_CG33874 | CG33874 gene product from transcript CG33874-RA |
| Drosophila melanogaster | Dmel_CG33894 | CG33894 gene product from transcript CG33894-RA |
| Drosophila melanogaster | Dmel_CG33876 | CG33876 gene product from transcript CG33876-RA |
| Echinococcus granulosus | EgrG_000322800 | histone H2B |
| Echinococcus granulosus | EgrG_000306200 | histone cluster 1, H2bb |
| Echinococcus granulosus | EgrG_000323300 | histone H2B |
| Echinococcus granulosus | EgrG_000472800 | histone H2B |
| Entamoeba histolytica | EHI_182990 | histone H2B, putative |
| Entamoeba histolytica | EHI_188730 | histone H2B, putative |
| Echinococcus multilocularis | EmuJ_000387800 | histone H2B |
| Echinococcus multilocularis | EmuJ_000383700 | histone H2B |
| Echinococcus multilocularis | EmuJ_000336700 | histone H2B |
| Echinococcus multilocularis | EmuJ_000336500 | histone H2B |
| Echinococcus multilocularis | EmuJ_000566500 | histone H2B |
| Echinococcus multilocularis | EmuJ_000328600 | histone H2B |
| Echinococcus multilocularis | EmuJ_000323300 | histone H2B |
| Echinococcus multilocularis | EmuJ_000387300 | histone H2B |
| Echinococcus multilocularis | EmuJ_000398500 | histone H2B |
| Echinococcus multilocularis | EmuJ_000385200 | histone H2B |
| Echinococcus multilocularis | EmuJ_000367300 | histone H2B |
| Echinococcus multilocularis | EmuJ_000037500 | histone H2B |
| Echinococcus multilocularis | EmuJ_000384300 | histone H2B |
| Echinococcus multilocularis | EmuJ_000472800 | histone H2B |
| Echinococcus multilocularis | EmuJ_000386300 | histone H2B |
| Echinococcus multilocularis | EmuJ_001203100 | histone H2B |
| Echinococcus multilocularis | EmuJ_000384800 | histone H2B |
| Echinococcus multilocularis | EmuJ_000322800 | histone H2B |
| Echinococcus multilocularis | EmuJ_000384000 | histone H2B |
| Echinococcus multilocularis | EmuJ_000386000 | histone H2B |
| Echinococcus multilocularis | EmuJ_000367600 | histone H2B |
| Echinococcus multilocularis | EmuJ_000386800 | histone H2B |
| Echinococcus multilocularis | EmuJ_000027400 | histone H2B |
| Echinococcus multilocularis | EmuJ_000279100 | histone H2B |
| Echinococcus multilocularis | EmuJ_000336900 | histone H2B |
| Echinococcus multilocularis | EmuJ_000385700 | histone H2B |
| Giardia lamblia | GL50803_121046 | Histone H2B |
| Giardia lamblia | GL50803_121045 | Histone H2B |
| Homo sapiens | ENSG00000146047 | histone cluster 1, H2ba |
| Homo sapiens | ENSG00000184678 | histone cluster 2, H2be |
| Homo sapiens | 8970 | histone cluster 1, H2bj |
| Homo sapiens | ENSG00000278588 | histone cluster 1, H2bi |
| Homo sapiens | ENSG00000185130 | histone cluster 1, H2bl |
| Homo sapiens | ENSG00000277224 | histone cluster 1, H2bf |
| Homo sapiens | 8339 | histone cluster 1, H2bg |
| Homo sapiens | 85236 | histone cluster 1, H2bk |
| Homo sapiens | ENSG00000274641 | histone cluster 1, H2bo |
| Homo sapiens | ENSG00000158373 | histone cluster 1, H2bd |
| Homo sapiens | 102724334 | histone H2B type F-S-like |
| Homo sapiens | ENSG00000168298 | histone cluster 1, H1e |
| Homo sapiens | ENSG00000274290 | histone cluster 1, H2be |
| Homo sapiens | ENSG00000275713 | histone cluster 1, H2bh |
| Homo sapiens | ENSG00000276410 | histone cluster 1, H2bb |
| Homo sapiens | 8341 | histone cluster 1, H2bn |
| Homo sapiens | 128312 | histone cluster 3, H2bb |
| Homo sapiens | ENSG00000273703 | histone cluster 1, H2bm |
| Homo sapiens | 8347 | histone cluster 1, H2bc |
| Leishmania braziliensis | LbrM.28.0220 | histone H2B variant |
| Leishmania braziliensis | LbrM.19.0350 | histone H2B |
| Leishmania braziliensis | LbrM.19.0340 | histone H2B |
| Leishmania braziliensis | LbrM.09.1400 | histone H2B |
| Leishmania braziliensis | LbrM.19.0360 | histone H2B |
| Leishmania donovani | LdBPK_190040.1 | histone H2B |
| Leishmania donovani | LdBPK_280210.1 | Histone H2B variant V |
| Leishmania donovani | LdBPK_171320.1 | histone H2B |
| Leishmania donovani | LdBPK_091410.1 | histone H2B |
| Leishmania infantum | LinJ.28.0210 | histone H2B variant |
| Leishmania infantum | LinJ.09.1410 | histone H2B |
| Leishmania infantum | LinJ.19.0030 | histone H2B |
| Leishmania infantum | LinJ.19.0040 | histone H2B |
| Leishmania infantum | LinJ.17.1320 | histone H2B |
| Leishmania major | LmjF.28.0210 | histone H2B variant |
| Leishmania major | LmjF.17.1220 | histone H2B |
| Leishmania major | LmjF.19.0030 | histone H2B |
| Leishmania major | LmjF.19.0040 | histone H2B |
| Leishmania major | LmjF.09.1340 | histone H2B |
| Leishmania major | LmjF.19.0050 | histone H2B |
| Leishmania mexicana | LmxM.19.0030 | histone H2B |
| Leishmania mexicana | LmxM.17.1220 | histone H2B |
| Leishmania mexicana | LmxM.09.1340 | histone H2B |
| Leishmania mexicana | LmxM.28.0210 | histone H2B variant |
| Leishmania mexicana | LmxM.19.0050 | histone H2B |
| Loa Loa (eye worm) | LOAG_10470 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_14097 | histone H2B 2 |
| Loa Loa (eye worm) | LOAG_10011 | hypothetical protein |
| Mus musculus | ENSMUSG00000018102 | histone cluster 1, H2bc |
| Mus musculus | ENSMUSG00000069307 | histone cluster 1, H2bq |
| Mus musculus | 319181 | histone cluster 1, H2bg |
| Mus musculus | ENSMUSG00000069300 | histone cluster 1, H2bj |
| Mus musculus | ENSMUSG00000069308 | histone cluster 1, H2bp |
| Mus musculus | ENSMUSG00000062727 | histone cluster 1, H2bk |
| Mus musculus | ENSMUSG00000047246 | histone cluster 1, H2be |
| Mus musculus | ENSMUSG00000095217 | histone cluster 1, H2bn |
| Mus musculus | ENSMUSG00000069268 | histone cluster 1, H2bf |
| Mus musculus | ENSMUSG00000075031 | histone cluster 1, H2bb |
| Mus musculus | ENSMUSG00000068854 | histone cluster 2, H2be |
| Mus musculus | ENSMUSG00000094338 | histone cluster 1, H2bl |
| Mus musculus | ENSMUSG00000096807 | histone cluster 1, H2bm |
| Mus musculus | 665622 | histone cluster 1 H2br |
| Mus musculus | ENSMUSG00000056895 | histone cluster 3, H2ba |
| Mus musculus | ENSMUSG00000050799 | histone cluster 1, H2ba |
| Mus musculus | ENSMUSG00000064168 | histone cluster 1, H2bh |
| Neospora caninum | NCLIV_066910 | Histone H2B, related |
| Neospora caninum | NCLIV_001070 | Histone H2B, related |
| Neospora caninum | NCLIV_004160 | Histone H2B, related |
| Oryza sativa | 4324512 | Os01g0149600 |
| Oryza sativa | 4324498 | Os01g0152700 |
| Oryza sativa | 4324510 | Os01g0149400 |
| Oryza sativa | 4345904 | Os08g0490900 |
| Oryza sativa | 4324500 | Os01g0152900 |
| Oryza sativa | 4324502 | Os01g0153100 |
| Oryza sativa | 9267011 | Os01g0597201 |
| Oryza sativa | 4324495 | Os01g0152300 |
| Oryza sativa | 4339681 | Os05g0574300 |
| Oryza sativa | 4324504 | Os01g0153300 |
| Oryza sativa | 9268195 | Os09g0570850 |
| Oryza sativa | 4327384 | Os01g0839500 |
| Onchocerca volvulus | OVOC1239 |
|
| Onchocerca volvulus | OVOC7893 |
|
| Onchocerca volvulus | OVOC1638 |
|
| Onchocerca volvulus | OVOC1639 |
|
| Onchocerca volvulus | OVOC1235 |
|
| Onchocerca volvulus | OVOC4061 |
|
| Plasmodium berghei | PBANKA_1420600 | histone H2B variant, putative |
| Plasmodium berghei | PBANKA_0941800 | histone H2B, putative |
| Plasmodium falciparum | PF3D7_1105100 | histone H2B |
| Plasmodium falciparum | PF3D7_0714000 | histone H2B variant |
| Plasmodium knowlesi | PKNH_0902700 | histone H2B, putative |
| Plasmodium knowlesi | PKNH_1422900 | histone H2B variant, putative |
| Plasmodium vivax | PVX_122930 | histone H2B variant, putative |
| Plasmodium vivax | PVX_090935 | histone 2B |
| Plasmodium yoelii | PY02616 | histone H2B variant 1 |
| Saccharomyces cerevisiae | YDR224C | histone H2B |
| Saccharomyces cerevisiae | YBL002W | histone H2B |
| Schistosoma japonicum | Sjp_0006730 | Histone H2B, gonadal, putative |
| Schistosoma japonicum | Sjp_0314840 | expressed protein |
| Schistosoma japonicum | Sjp_0036400 | Histone H2B, putative |
| Schistosoma japonicum | Sjp_0016080 | Histone H2B, gonadal, putative |
| Schistosoma japonicum | Sjp_0036390 | Histone H2B, gonadal, putative |
| Schistosoma mansoni | Smp_036220 | histone H2B |
| Schistosoma mansoni | Smp_108390 | histone H2B |
| Schistosoma mansoni | Smp_121380 | histone H2B |
| Schmidtea mediterranea | mk4.023146.01 | |
| Schmidtea mediterranea | mk4.015823.02 | |
| Schmidtea mediterranea | mk4.000688.07 | Histone H2B |
| Schmidtea mediterranea | mk4.000572.09 | Histone H2B |
| Schmidtea mediterranea | mk4.019784.02 | |
| Schmidtea mediterranea | mk4.002212.01 | Histone H2B |
| Schmidtea mediterranea | mk4.045597.00 | |
| Schmidtea mediterranea | mk4.005020.01 | Histone H2B |
| Schmidtea mediterranea | mk4.000688.06 | Histone H2B |
| Schmidtea mediterranea | mk4.021105.00 | Histone H2B |
| Schmidtea mediterranea | mk4.000124.04 | Histone H2B |
| Schmidtea mediterranea | mk4.014609.00 | |
| Schmidtea mediterranea | mk4.000756.08 | Histone H2B |
| Schmidtea mediterranea | mk4.006479.00 | Histone H2B |
| Schmidtea mediterranea | mk4.000063.03 | Histone H2B |
| Schmidtea mediterranea | mk4.000525.05 | |
| Schmidtea mediterranea | mk4.014939.01 | Histone H2B |
| Schmidtea mediterranea | mk4.008285.00 | |
| Schmidtea mediterranea | mk4.013070.00 | |
| Schmidtea mediterranea | mk4.011360.01 | |
| Trypanosoma brucei gambiense | Tbg972.10.12830 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12840 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.11.8400 | histone H2B variant, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12780 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12800 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12740 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12770 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12790 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12810 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12750 | histone H2B, putative |
| Trypanosoma brucei gambiense | Tbg972.10.12820 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10560 | histone H2B, putative |
| Trypanosoma brucei | Tb927.11.7350 | Histone H2B variant V |
| Trypanosoma brucei | Tb927.10.10590 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10460 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10490 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10540 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10480 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10580 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10470 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10530 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10570 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10510 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10550 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10500 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10520 | histone H2B, putative |
| Trypanosoma brucei | Tb927.10.10445 | Core histone H2A/H2B/H3/H4, putative |
| Trypanosoma congolense | TcIL3000_10_8920 | histone H2B, putative |
| Trypanosoma congolense | TcIL3000_10_8910 | histone H2B, putative |
| Trypanosoma cruzi | TcCLB.511635.10 | histone H2B, putative |
| Trypanosoma cruzi | TcCLB.511153.64 | Histone H2B variant V |
| Trypanosoma cruzi | TcCLB.506779.150 | Histone H2B variant V |
| Trypanosoma cruzi | TcCLB.511635.20 | histone H2B, putative |
| Toxoplasma gondii | TGME49_251870 | histone H2Bb |
| Toxoplasma gondii | TGME49_209910 | histone H2Bv |
| Toxoplasma gondii | TGME49_305160 | histone H2Ba |
| Theileria parva | TP04_0404 | histone H2B-III, putative |
| Theileria parva | TP04_0071 | histone H2B, putative |
| Trichomonas vaginalis | TVAG_268820 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_321390 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_380920 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_195300 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_329270 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_226780 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_464720 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_045410 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_105960 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_026390 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_447850 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_144040 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_228640 | histone H2b, putative |
| Trichomonas vaginalis | TVAG_075290 | histone H2b, putative |
Essentiality
Smp_108390 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.10.10590 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.10.10590 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
| Tb927.10.10590 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.10.10590 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_T10C6.11 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_T10C6.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T10C6.11 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T10C6.11 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T10C6.11 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T10C6.11 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F45F2.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F45F2.12 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F45F2.12 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F45F2.12 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.5 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.5 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.9 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.9 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.9 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.9 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K06C4.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K06C4.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.4 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.4 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.4 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K06C4.12 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K06C4.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.12 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.12 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.12 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F35H10.11 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F35H10.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F35H10.11 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F35H10.11 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F17E9.9 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F17E9.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F17E9.9 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F17E9.9 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_C50F4.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C50F4.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_C50F4.5 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F08G2.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F08G2.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F08G2.1 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F08G2.1 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F08G2.1 | Caenorhabditis elegans | sterile | wormbase |
| CELE_B0035.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_B0035.8 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_B0035.8 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_B0035.8 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_B0035.8 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F07B7.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F07B7.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F07B7.4 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F07B7.4 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F07B7.4 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F07B7.11 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F07B7.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F07B7.11 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F07B7.11 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F07B7.11 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F54E12.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F54E12.4 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F54E12.4 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F54E12.4 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F55G1.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F55G1.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F55G1.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_H02I12.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_H02I12.6 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_H02I12.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_H02I12.6 | Caenorhabditis elegans | sterile | wormbase |
| YDR224C | Saccharomyces cerevisiae | inviable | yeastgenome |
| PBANKA_0941800 | Plasmodium berghei | Essential | plasmo |
| PBANKA_1420600 | Plasmodium berghei | Essential | plasmo |
| TGME49_305160 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_251870 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_209910 | Toxoplasma gondii | Probably essential | sidik |
| TGME49_305160 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_251870 | Toxoplasma gondii | Probably non-essential | sidik |
| TGME49_209910 | Toxoplasma gondii | Probably non-essential | sidik |
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keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
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