pI: 6.795 |
Length (AA): 936 |
MW (Da): 103114 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
300 | 558 | 1got (B) | 84 | 340 | 24.00 | 0 | 1 | 0.66 | -0.73 |
400 | 772 | 2h14 (A) | 43 | 331 | 18.00 | 0 | 1 | 0.32 | 0.23 |
4 | 686 | 5i2t (A) | 4 | 678 | 35.00 | 0 | 1 | 0.889501 | 0.83 |
20 | 114 | 5c2v (B) | 136 | 240 | 34.00 | 0.025 | 0.93 | 0.457296 | -0.5 |
257 | 669 | 4wju (A) | 40 | 513 | 25.00 | 0.000000084 | 1 | 0.399039 | 0.95 |
417 | 558 | 2ovr (B) | 2394 | 2527 | 27.00 | 0.00003 | 1 | 0.550509 | -0.86 |
495 | 661 | 3jro (A) | 17 | 177 | 36.00 | 0.027 | 0.3 | 0.284219 | 0.77 |
791 | 874 | 2p9p (G) | 52 | 137 | 15.00 | 0.5 | 0.16 | 0.314844 | -0.8 |
801 | 921 | 5ica (D) | 729 | 847 | 27.00 | 0 | 0.97 | 0.508373 | -0.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | epimastigote, metacyclic. | Smircich P |
Smircich P | Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. |
Ortholog group members (OG5_128106)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G15440 | periodic tryptophan protein 2 |
Babesia bovis | BBOV_II001010 | periodic tryptophan protein 2-like protein, putative |
Brugia malayi | Bm1_08665 | Periodic tryptophan protein 2 homolog |
Candida albicans | CaO19.3276 | bud-site selection, cell polarity, cytokinesis |
Candida albicans | CaO19.10786 | bud-site selection, cell polarity, cytokinesis |
Caenorhabditis elegans | CELE_F55F8.3 | Protein F55F8.3 |
Cryptosporidium hominis | Chro.20305 | WD repeat protein |
Cryptosporidium parvum | cgd2_2910 | large WD repeat protein |
Dictyostelium discoideum | DDB_G0284621 | WD40 repeat-containing protein |
Drosophila melanogaster | Dmel_CG12325 | CG12325 gene product from transcript CG12325-RB |
Echinococcus granulosus | EgrG_000886300 | periodic tryptophan protein 2 |
Entamoeba histolytica | EHI_151370 | WD domain containing protein |
Echinococcus multilocularis | EmuJ_000886300 | periodic tryptophan protein 2 |
Giardia lamblia | GL50803_94653 | Periodic tryptophan protein 2-like protein |
Homo sapiens | ENSG00000275464 | periodic tryptophan protein 2 homolog |
Homo sapiens | ENSG00000241945 | PWP2 periodic tryptophan protein homolog (yeast) |
Leishmania braziliensis | LbrM.18.0920 | periodic tryptophan protein 2-like protein |
Leishmania donovani | LdBPK_180830.1 | Periodic tryptophan protein 2 homolog, putative |
Leishmania infantum | LinJ.18.0830 | periodic tryptophan protein 2-like protein |
Leishmania major | LmjF.18.0830 | periodic tryptophan protein 2-like protein |
Leishmania mexicana | LmxM.18.0830 | periodic tryptophan protein 2-like protein |
Loa Loa (eye worm) | LOAG_02916 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12593 | wd-repeat protein |
Mus musculus | ENSMUSG00000032834 | PWP2 periodic tryptophan protein homolog (yeast) |
Neospora caninum | NCLIV_002140 | WD repeat protein, related |
Oryza sativa | 4339341 | Os05g0519500 |
Onchocerca volvulus | OVOC13466 |
|
Onchocerca volvulus | OVOC7856 | Periodic tryptophan protein 2 homolog |
Plasmodium berghei | PBANKA_1227900 | periodic tryptophan protein 2, putative |
Plasmodium falciparum | PF3D7_0802300 | periodic tryptophan protein 2, putative |
Plasmodium knowlesi | PKNH_0116600 | periodic tryptophan protein 2, putative |
Plasmodium vivax | PVX_093625 | hypothetical protein, conserved |
Plasmodium yoelii | PY04284 | WD-repeat protein p103 |
Saccharomyces cerevisiae | YCR057C | Pwp2p |
Schistosoma japonicum | Sjp_0118270 | Periodic tryptophan protein 2 homolog, putative |
Schistosoma japonicum | Sjp_0128350 | Periodic tryptophan protein 2 homolog, putative |
Schistosoma japonicum | Sjp_0125030 | Periodic tryptophan protein 2 homolog, putative |
Schistosoma japonicum | Sjp_0128210 | Periodic tryptophan protein 2 homolog, putative |
Schistosoma japonicum | Sjp_0119730 | Periodic tryptophan protein 2 homolog, putative |
Schistosoma japonicum | Sjp_0212000 | IPR007190,Periodic tryptophan protein-associated region,domain-containing |
Schistosoma japonicum | Sjp_0117560 | expressed protein |
Schistosoma mansoni | Smp_126910 | hypothetical protein |
Schmidtea mediterranea | mk4.004114.05 | Periodic tryptophan protein 2 homolog |
Schmidtea mediterranea | mk4.004114.06 | |
Schmidtea mediterranea | mk4.004114.04 | Periodic tryptophan protein 2 homolog |
Schmidtea mediterranea | mk4.018422.00 | Periodic tryptophan protein 2 homolog |
Trypanosoma brucei gambiense | Tbg972.10.16040 | periodic tryptophan protein 2, putative,predicted WD40 repeat protein |
Trypanosoma brucei | Tb11.v5.0563 | periodic tryptophan protein 2, putative |
Trypanosoma congolense | TcIL3000_10_11360 | Periodic tryptophan protein 2 homolog, putative |
Trypanosoma cruzi | TcCLB.506357.140 | Periodic tryptophan protein 2 homolog, putative |
Toxoplasma gondii | TGME49_295680 | periodic tryptophan protein PWP2, putative |
Theileria parva | TP04_0485 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_166140 | WD repeat domain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.13270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.13270 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.13270 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.13270 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F55F8.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F55F8.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F55F8.3 | Caenorhabditis elegans | sterile | wormbase |
YCR057C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_295680 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.