Detailed view for PF3D7_0201900

Basic information

TDR Targets ID: 3291
Plasmodium falciparum, erythrocyte membrane protein 3
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4902 | Length (AA): 2441 | MW (Da): 273647 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0003674   molecular_function  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 14 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 113 3na7 (A) 25 132 14.00 0.87 0.02 0.184715 -0.47
71 217 3k29 (A) 10 162 20.00 0.089 0.04 0.402021 -2.15
88 230 1jad (A) 89 241 24.00 0.6 0.2 0.262783 -1.48
94 274 4tko (B) 67 233 34.00 0.048 0.2 0.39335 -1.03
100 299 4tql (A) 10 221 31.00 0.00032 0.89 0.467134 -1.2
823 989 4uos (A) 6 183 28.00 0.0043 0.99 0.598615 -2.35
865 1269 4r5d (A) 26 414 30.00 0.0002 0.12 0.205116 0.59
1148 1518 4u09 (A) 34 405 29.00 0.028 0.45 0.355187 -0.22
1888 2399 4ut1 (A) 96 627 16.00 0.15 0.06 0.33955 -0.51
10 194 4waf (B) 374 579 20.00 0.31 0.05 0.155531 -0.27
77 175 3ryc (E) 43 145 31.00 0.88 0.02 0.507702 -2.22
96 285 4uos (A) 2 184 25.00 0.00086 0.84 0.599905 -2.19
139 361 4uos (A) 1 187 34.00 0.029 0.94 0.488372 -1.27
1073 1474 4u09 (A) 34 405 29.00 0.0023 0.94 0.539155 -0.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile merozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, Male Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 48 hs, Oocyst, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_132376)

Species Accession Gene Product
Babesia bovis BBOV_II003500   hypothetical protein
Mycobacterium tuberculosis Rv0442c   PPE family protein PPE10
Mycobacterium tuberculosis Rv2356c   PPE family protein PPE40
Mycobacterium tuberculosis Rv3144c   PPE family protein PPE52
Mycobacterium tuberculosis Rv0755c   PPE family protein PPE12
Mycobacterium tuberculosis Rv0878c   PPE family protein PPE13
Mycobacterium tuberculosis Rv1135c   PPE family protein PPE16
Mycobacterium tuberculosis Rv1548c   PPE family protein PPE21
Mycobacterium tuberculosis Rv1753c   PPE family protein PPE24
Mycobacterium tuberculosis Rv1917c   PPE family protein PPE34
Mycobacterium tuberculosis Rv1918c   PPE family protein PPE35
Mycobacterium tuberculosis Rv2353c   PPE family protein PPE39
Mycobacterium tuberculosis Rv0304c   PPE family protein PPE5
Mycobacterium tuberculosis Rv3159c   PPE family protein PPE53
Mycobacterium tuberculosis Rv3343c   PPE family protein PPE54
Mycobacterium tuberculosis Rv3347c   PPE family protein PPE55
Mycobacterium tuberculosis Rv3350c   PPE family protein PPE56
Mycobacterium tuberculosis Rv0305c   PPE family protein PPE6
Mycobacterium tuberculosis Rv3558   PPE family protein PPE64
Mycobacterium tuberculosis Rv0355c   PPE family protein PPE8
Mycobacterium ulcerans MUL_0098   PPE family protein
Mycobacterium ulcerans MUL_1395   PPE family protein
Mycobacterium ulcerans MUL_0890   PPE family protein
Mycobacterium ulcerans MUL_0782   PPE family protein
Mycobacterium ulcerans MUL_0902   PPE family protein
Mycobacterium ulcerans MUL_0965   PPE family protein
Mycobacterium ulcerans MUL_0964   PPE family protein
Mycobacterium ulcerans MUL_4491   PPE family protein
Plasmodium falciparum PF3D7_0201900   erythrocyte membrane protein 3

Essentiality

PF3D7_0201900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu769 Mycobacterium tuberculosis essential nmpdr
mtu894 Mycobacterium tuberculosis non-essential nmpdr
mtu1155 Mycobacterium tuberculosis non-essential nmpdr
mtu1783 Mycobacterium tuberculosis essential nmpdr
mtu1948 Mycobacterium tuberculosis non-essential nmpdr
mtu1949 Mycobacterium tuberculosis non-essential nmpdr
mtu307 Mycobacterium tuberculosis non-essential nmpdr
mtu3403 Mycobacterium tuberculosis essential nmpdr
mtu308 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0201900 (Plasmodium falciparum), erythrocyte membrane protein 3
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