pI: 6.2432 |
Length (AA): 219 |
MW (Da): 25229 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 219 | 1dzf (A) | 5 | 215 | 36.00 | 0 | 1 | 1.35 | -0.73 |
10 | 219 | 5xog (E) | 3 | 214 | 36.00 | 0 | 1 | 1.389 | -0.27 |
10 | 219 | 2e2h (E) | 3 | 215 | 38.00 | 0 | 1 | 1.235 | 0.77 |
17 | 219 | 1dzf (A) | 11 | 215 | 38.00 | 0 | 1 | 1.35614 | -0.24 |
146 | 219 | 4qiw (H) | 7 | 80 | 45.00 | 0 | 1 | 0.865 | 0.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127455)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G22320 | DNA-directed RNA polymerase NRPB5 |
Babesia bovis | BBOV_III009920 | RNA polymerase Rpb5, N-terminal domain containing protein |
Candida albicans | CaO19.13696 | RNA polymerase subunit |
Candida albicans | CaO19.6340 | RNA polymerase subunit |
Caenorhabditis elegans | CELE_H27M09.2 | Protein RPB-5 |
Cryptosporidium hominis | Chro.20109 | DNA-directed RNA polymerase 2 |
Cryptosporidium parvum | cgd2_980 | putative DNA-directed RNA polymerase 2 |
Dictyostelium discoideum | DDB_G0291636 | RNA polymerase I core subunit |
Drosophila melanogaster | Dmel_CG11979 | CG11979 gene product from transcript CG11979-RB |
Echinococcus granulosus | EgrG_000641000 | dna directed rna polymerases i ii and iii |
Entamoeba histolytica | EHI_142090 | RNA polymerase subunit Rpb5, putative |
Echinococcus multilocularis | EmuJ_000641000 | DNA directed RNA polymerases I, II, and III |
Giardia lamblia | GL50803_8157 | RNA polymerase II subunit Rpb5b |
Giardia lamblia | GL50803_137609 | RNA polymerase II subunit Rpb5a |
Homo sapiens | ENSG00000099817 | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa |
Leishmania braziliensis | LbrM.18.0870 | DNA-directed RNA polymerases II, putative |
Leishmania donovani | LdBPK_180780.1 | DNA-directed RNA polymerases II, putative |
Leishmania infantum | LinJ.18.0780 | DNA-directed RNA polymerases II, putative |
Leishmania major | LmjF.18.0780 | DNA-directed RNA polymerases II, putative |
Leishmania mexicana | LmxM.18.0780 | DNA-directed RNA polymerases II, putative |
Loa Loa (eye worm) | LOAG_12762 | RPB-5 protein |
Mus musculus | ENSMUSG00000004667 | polymerase (RNA) II (DNA directed) polypeptide E |
Neospora caninum | NCLIV_016790 | DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative |
Oryza sativa | 9270850 | Os04g0487300 |
Oryza sativa | 4327549 | Os01g0805800 |
Plasmodium berghei | PBANKA_1140600 | DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative |
Plasmodium falciparum | PF3D7_1364800 | DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative |
Plasmodium knowlesi | PKNH_1106500 | DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative |
Plasmodium vivax | PVX_115200 | DNA-directed RNA polymerase II 23 kDa polypeptide, putative |
Plasmodium yoelii | PY02779 | RNA polymerase Rpb5, C-terminal domain, putative |
Saccharomyces cerevisiae | YBR154C | DNA-directed RNA polymerase core subunit RPB5 |
Schistosoma japonicum | Sjp_0079490 | ko:K03013 DNA-directed RNA polymerase II subunit E, putative |
Schistosoma mansoni | Smp_126370 | DNA-directed RNA polymerase II |
Schmidtea mediterranea | mk4.002395.07 | DNA-directed RNA polymerases I, II, and III subunit RPABC1 |
Schmidtea mediterranea | mk4.003520.01 | DNA-directed RNA polymerases I, II, and III subunit RPABC1 |
Trypanosoma brucei gambiense | Tbg972.10.16090 | DNA-directed RNA polymerases II subunit, putative |
Trypanosoma brucei | Tb927.10.13320 | DNA-directed RNA polymerase II/III subunit, putative |
Trypanosoma congolense | TcIL3000_10_11420 | DNA-directed RNA polymerases II subunit, putative |
Trypanosoma cruzi | TcCLB.506357.90 | DNA-directed RNA polymerase II/III subunit, putative |
Trypanosoma cruzi | TcCLB.511277.20 | DNA-directed RNA polymerase II/III subunit, putative |
Toxoplasma gondii | TGME49_240590 | DNA-directed RNA polymerase II RPB5 |
Theileria parva | TP04_0911 | DNA-directed RNA polymerase II, putative |
Trichomonas vaginalis | TVAG_171980 | DNA-directed RNA polymerase II, putative |
Trichomonas vaginalis | TVAG_113600 | DNA-directed RNA polymerase II, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.13320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.13320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.13320 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.13320 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_H27M09.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H27M09.2 | Caenorhabditis elegans | sterile | wormbase |
YBR154C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1140600 | Plasmodium berghei | Essential | plasmo |
TGME49_240590 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.