Detailed view for TcCLB.503599.10

Basic information

TDR Targets ID: 33041
Trypanosoma cruzi, calcium/calmodulin-dependent protein kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.4681 | Length (AA): 502 | MW (Da): 56605 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 401 2etr (A) 46 404 23.00 0 1 0.77 0.28
23 324 1yrp (A) 9 276 34.00 0 1 0.93 -0.67
9 477 3hx4 (A) 31 463 27.00 0 1 1.08956 0.34
25 323 2y7j (A) 24 291 38.00 0 1 0.907518 -0.41
32 386 5dvr (A) 56 445 30.00 0 1 0.907771 0.04
135 257 2qkw (B) 151 238 45.00 0.00053 0.27 0.11092 1.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile epimastigote, metacyclic. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_165260)

Species Accession Gene Product
Leishmania braziliensis LbrM.27.0360   protein kinase, putative
Leishmania donovani LdBPK_351070.1   protein kinase, putative
Leishmania infantum LinJ.35.1070   protein kinase, putative
Leishmania major LmjF.35.1050   protein kinase, putative
Leishmania mexicana LmxM.34.1050   protein kinase, putative
Trypanosoma cruzi TcCLB.503599.10   calcium/calmodulin-dependent protein kinase, putative
Trypanosoma cruzi TcCLB.509409.10   calcium/calmodulin-dependent protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 24.6% 390 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 26.6% 335 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 27.9% 305 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 20.6% 326 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 24.7% 198 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 27.9% 305 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 25.1% 346 aa Compounds References
Sus scrofa Glycogen synthase kinase 3 beta 420 aa 25.2% 349 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.0% 327 aa Compounds References
Patiria pectinifera Cdc2 300 aa 25.8% 318 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.6% 324 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 23.6% 275 aa Compounds References
Rattus norvegicus c-Jun N-terminal kinase 3 464 aa 22.7% 405 aa Compounds References
Rattus norvegicus Glycogen synthase kinase-3 beta 420 aa 24.9% 346 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 24.8% 327 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 25.9% 321 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 23.5% 328 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.8% 317 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.5% 321 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 24.9% 265 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 29.3% 208 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0064 0.3377 0
0.0008 0.5 0.5
0.0018 0.5 0.5
0.0061 0.6883 0.5304
0.0027 1 0.5
0.0022 0.5 0.5
0.0069 0.3067 1
0.0042 0.5 0.5
0.0063 1 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.0093 0.8828 0
0.0039 0.5 0.5
0.0023 0.5 0.5
0.0056 1 0.5
0.0088 0.4477 0.5
0.0039 0.9485 0.5
0.0092 1 0.5
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0029 0.5 0.5
0.0033 0.5 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0063 0.7244 0.2543
0.0003 0.5 0.5
0.0033 1 0.5
0.0026 0.5 0.5
0.0062 0.6935 0
0.0004 0.5 0.5
0.0016 0.5 0.5
0.0098 0.3242 0.3649
0.0081 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0016 0.5 0.5
0.0036 0.5 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0067 0.5 0.5
0.0011 1 0.5
0.0059 1 1
0.0037 1 0.5
0.0091 1 0.5
0.0081 1 0.5
0.0066 0.3101 0

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.503599.10 (Trypanosoma cruzi), calcium/calmodulin-dependent protein kinase, putative
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